navitoclax
Ligand Summary
Name: navitoclax
PubChem: 24978538
Guide to Pharmacology: 8319
ChEMBL: CHEMBL443684
LyCHI: 8C32YB1UVPFV
Target Activities
BCL2L1
Bcl-2-like protein 1
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9 | |||||
Ki | 10.26 | J Med Chem, (2018) 61:7:2636 | ||||
IC50 | 8.48 | J. Med. Chem., (2013) 56:23:9635 | ||||
IC50 | 8.09 | Bioorg Med Chem, (2018) 26:2:443 | ||||
Ki | 7.44 | J. Med. Chem., (2010) 53:19:6779 | ||||
Ki | 7.32 | Eur J Med Chem, (2019) 167:None:76 | ||||
IC50 | 7.22 | Bioorg. Med. Chem. Lett., (2014) 24:14:3026 | ||||
BCL2
Apoptosis regulator Bcl-2
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9 | |||||
Ki | 10.36 | J Med Chem, (2018) 61:7:2636 | ||||
Ki | 10.36 | J Med Chem, (2019) 62:22:10005 | ||||
IC50 | 8.7 | Bioorg Med Chem Lett, (2019) 29:23:126682 | ||||
IC50 | 7.99 | Bioorg Med Chem, (2018) 26:2:443 | ||||
BCL2L2
Bcl-2-like protein 2
2 Activities
MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.3 | MedChemComm, (2016) 7:5:778 | ||||
Ki | 6.26 | Eur J Med Chem, (2018) 146:None:471 | ||||