Pharos : Ligand Details

Target Activities

AKT1

Tchem

RAC-alpha serine/threonine-protein kinase

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.65999985		22037378

IC50	8.69999981		18800763

IC50	9.22	ACS Med. Chem. Lett., (2014) 5:5:462	24900862

Ki	9	J. Med. Chem., (2008) 51:18:5663	18800763

Ki	9	Bioorg. Med. Chem. Lett., (2009) 19:5:1508	19179070

IC50	8.77	Eur J Med Chem, (2017) 138:None:543	28704757

IC50	8.7	J. Med. Chem., (2008) 51:18:5663	18800763

IC50	8.7	Bioorg. Med. Chem. Lett., (2009) 19:5:1508	19179070

Kd	8.66	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.67	MedChemComm, (2018) 9:8:1340

AKT2

Tchem

RAC-beta serine/threonine-protein kinase

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.88999987		18800763

Kd	8.68	Nat. Biotechnol., (2011) 29:11:1046	22037378

Ki	8.4	J. Med. Chem., (2008) 51:18:5663	18800763

Ki	8.4	Bioorg. Med. Chem. Lett., (2009) 19:5:1508	19179070

IC50	7.89	J. Med. Chem., (2008) 51:18:5663	18800763

IC50	7.89	Bioorg. Med. Chem. Lett., (2009) 19:5:1508	19179070

AKT3

Tchem

RAC-gamma serine/threonine-protein kinase

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.05000019		18800763

Kd	8.52	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.05	J. Med. Chem., (2008) 51:18:5663	18800763

IC50	8.05	Bioorg. Med. Chem. Lett., (2009) 19:5:1508	19179070

Ki	7.89	J. Med. Chem., (2008) 51:18:5663	18800763

PRKCQ

Tchem

Protein kinase C theta type

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.69999981		18800763

IC50	8.7	J. Med. Chem., (2008) 51:18:5663	18800763

Kd	8	Science, (2017) 358:6367:None	29191878

Kd	7.8	Nat. Biotechnol., (2011) 29:11:1046	22037378

PAK4

Tchem

Serine/threonine-protein kinase PAK 4

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8		18800763

IC50	8	J. Med. Chem., (2008) 51:18:5663	18800763

Kd	7.75	Nat. Biotechnol., (2011) 29:11:1046	22037378

PAK6

Tchem

Serine/threonine-protein kinase PAK 6

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.22000027		18800763

IC50	8.22	J. Med. Chem., (2008) 51:18:5663	18800763

Kd	7.68	Nat. Biotechnol., (2011) 29:11:1046	22037378

PRKX

Tchem

cAMP-dependent protein kinase catalytic subunit PRKX

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.30000019		18800763

IC50	8.3	J. Med. Chem., (2008) 51:18:5663	18800763

Kd	8.14	Nat. Biotechnol., (2011) 29:11:1046	22037378

PAK5

Tchem

Serine/threonine-protein kinase PAK 5

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.28000021		18800763

Kd	8.05	Nat. Biotechnol., (2011) 29:11:1046	22037378

PRKCE

Tchem

Protein kinase C epsilon type

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.28	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.68	J. Med. Chem., (2008) 51:18:5663	18800763

PRKCH

Tchem

Protein kinase C eta type

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.7	J. Med. Chem., (2008) 51:18:5663	18800763

Kd	8.62	Nat. Biotechnol., (2011) 29:11:1046	22037378

PRKG1

Tchem

cGMP-dependent protein kinase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.48000002			18800763

PRKAG2

Tchem

5'-AMP-activated protein kinase subunit gamma-2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.11		Science, (2017) 358:6367:None	29191878

PRKAR2A

Tchem

cAMP-dependent protein kinase type II-alpha regulatory subunit

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.28		Science, (2017) 358:6367:None	29191878

PRKG2

Tchem

cGMP-dependent protein kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.51		Nat. Biotechnol., (2011) 29:11:1046	22037378

PRKACB

Tchem

cAMP-dependent protein kinase catalytic subunit beta

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.89		Nat. Biotechnol., (2011) 29:11:1046	22037378

PRKCD

Tclin

Protein kinase C delta type

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.85		J. Med. Chem., (2008) 51:18:5663	18800763

PRKCB

Tchem

Protein kinase C beta type

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.72		J. Med. Chem., (2008) 51:18:5663	18800763

PRKACA

Tchem

cAMP-dependent protein kinase catalytic subunit alpha

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.72		Nat. Biotechnol., (2011) 29:11:1046	22037378

DCTPP1

Tchem

dCTP pyrophosphatase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	6.24		Science, (2017) 358:6367:None	29191878