CHEMBL1808264
Ligand Summary
Name: 2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide
PubChem: 46927672
Guide to Pharmacology: 8783
ChEMBL: CHEMBL1808264
LyCHI: 86D7Q23H5BNV
Target Activities
BRAF
Serine/threonine-protein kinase B-raf
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.42 | Bioorg. Med. Chem. Lett., (2011) 21:15:4436 | ||||
IC50 | 8.42 | MedChemComm, (2017) 8:9:1835 | ||||
IC50 | 8.42 | MedChemComm, (2017) 8:9:1835 | ||||
EC50 | 7.64 | Bioorg. Med. Chem. Lett., (2011) 21:15:4436 | ||||
NCOA1
Nuclear receptor coactivator 1
2 Activities
LCK
Tyrosine-protein kinase Lck
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8 | Bioorg. Med. Chem. Lett., (2011) 21:15:4436 | ||||
LYN
Tyrosine-protein kinase Lyn
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8 | Bioorg. Med. Chem. Lett., (2011) 21:15:4436 | ||||
TGFBR1
TGF-beta receptor type-1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8 | Bioorg. Med. Chem. Lett., (2011) 21:15:4436 | ||||
BTK
Tyrosine-protein kinase BTK
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8 | Bioorg. Med. Chem. Lett., (2011) 21:15:4436 | ||||
ACVR2B
Activin receptor type-2B
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8 | Bioorg. Med. Chem. Lett., (2011) 21:15:4436 | ||||
ERBB4
Receptor tyrosine-protein kinase erbB-4
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8 | Bioorg. Med. Chem. Lett., (2011) 21:15:4436 | ||||