CHEMBL483158
Ligand Summary
Name: 4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid
PubChem: 24771867
Guide to Pharmacology: 7790
ChEMBL: CHEMBL483158
LyCHI: 7UQPBK5RH47B
Target Activities
AURKA
Aurora kinase A
9 Activities
Items per page:
1 – 9 of 9
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.15 | ACS Med. Chem. Lett., (2015) 6:6:630 | ||||
IC50 | 8.17 | J Med Chem, (2016) 59:15:7188 | ||||
IC50 | 8.92 | J. Med. Chem., (2012) 55:17:7392 | ||||
IC50 | 9 | Bioorg. Med. Chem. Lett., (2013) 23:12:3523 | ||||
IC50 | 9 | J. Med. Chem., (2009) 52:9:2629 | ||||
IC50 | 9 | J. Med. Chem., (2015) 58:1:362 | ||||
IC50 | 9.22 | None, (2016) None:None:None | ||||
IC50 | 10.4 | J Med Chem, (2016) 59:15:7188 | ||||
IC50 | 9 | |||||
AURKB
Aurora kinase B
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.82 | J Med Chem, (2016) 59:15:7188 | ||||
GABRA1
Gamma-aminobutyric acid receptor subunit alpha-1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.31 | ACS Med. Chem. Lett., (2015) 6:6:630 | ||||