alisertib
Ligand Summary
Name: alisertib
PubChem: 24771867
Guide to Pharmacology: 7790
ChEMBL: CHEMBL483158
LyCHI: 7UQPBK5RH47B
Target Activities
AURKA
Aurora kinase A
14 Activities
Items per page:
1 – 10 of 14
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9 | |||||
IC50 | 10.4 | J Med Chem, (2016) 59:15:7188 | ||||
Ki | 9.3 | None, None:None:None | ||||
IC50 | 9.22 | None, (2016) None:None:None | ||||
IC50 | 9 | J. Med. Chem., (2009) 52:9:2629 | ||||
IC50 | 9 | Bioorg. Med. Chem. Lett., (2013) 23:12:3523 | ||||
IC50 | 9 | J. Med. Chem., (2015) 58:1:362 | ||||
IC50 | 8.92 | J. Med. Chem., (2012) 55:17:7392 | ||||
IC50 | 8.92 | Eur J Med Chem, (2017) 140:None:1 | ||||
IC50 | 8.92 | Bioorg Med Chem, (2019) 27:1:65 | ||||
AURKB
Aurora kinase B
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.82 | J Med Chem, (2016) 59:15:7188 | ||||
Ki | 8.5 | None, None:None:None | ||||
GABRA1
Gamma-aminobutyric acid receptor subunit alpha-1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.31 | ACS Med. Chem. Lett., (2015) 6:6:630 | ||||
MCM4
DNA replication licensing factor MCM4
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 6.2 | Science, (2017) 358:6367:None | ||||
ACAD10
Acyl-CoA dehydrogenase family member 10
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.11 | Science, (2017) 358:6367:None | ||||
GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 6.74 | Science, (2017) 358:6367:None | ||||
DNAJA1
DnaJ homolog subfamily A member 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 6.02 | Science, (2017) 358:6367:None | ||||