Pharos : Ligand Details - 6WW1N6R5RSG5

You are using an outdated browser. Please upgrade your browser to improve your experience.

Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: Fingolimod phosphate

PubChem: 11452022

Guide to Pharmacology: 6996

ChEMBL: CHEMBL366208

LyCHI: 6WW1N6R5RSG5

Target Activities

Explore Associated and Predicted Targets

S1PR3

Tclin

Sphingosine 1-phosphate receptor 3

15 Activities

Items per page:

1 – 10 of 15

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	8.51			17114004

EC50	9.87		Bioorg. Med. Chem. Lett., (2010) 20:7:2264	20188554

EC50	8.7		Bioorg. Med. Chem., (2014) 22:15:4246	24909680

EC50	8.7		Bioorg Med Chem Lett, (2017) 27:6:1371	28236593

EC50	8.52		Bioorg. Med. Chem. Lett., (2012) 22:12:3973	22583616

EC50	8.51		J. Med. Chem., (2005) 48:16:5373	16078855

EC50	8.48		ACS Med. Chem. Lett., (2011) 2:5:368	24900318

EC50	8.48		Eur. J. Med. Chem., (2012) 51:None:92	22405291

EC50	8.3		J. Med. Chem., (2011) 54:19:6724	21838322

EC50	8.3		J. Med. Chem., (2016) 59:3:1003	26751273

S1PR1

Tclin

Sphingosine 1-phosphate receptor 1

15 Activities

Items per page:

1 – 10 of 15

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	10.92		Bioorg. Med. Chem. Lett., (2010) 20:7:2264	20188554

IC50	9.55		ACS Med. Chem. Lett., (2011) 2:2:97	24900286

EC50	9.55		J. Med. Chem., (2016) 59:6:2820	26924461

EC50	9.52		J. Med. Chem., (2005) 48:16:5373	16078855

EC50	9.52		Bioorg. Med. Chem. Lett., (2012) 22:12:3973	22583616

EC50	9.43		ACS Med. Chem. Lett., (2011) 2:5:368	24900318

EC50	9.43		Eur. J. Med. Chem., (2012) 51:None:92	22405291

EC50	9.4		Bioorg. Med. Chem. Lett., (2016) 26:2:466	26687487

EC50	8.7		Bioorg. Med. Chem. Lett., (2010) 20:7:2264	20188554

IC50	8.68		Bioorg. Med. Chem. Lett., (2012) 22:1:553	22119341

S1PR5

Tclin

Sphingosine 1-phosphate receptor 5

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	9.52		J. Med. Chem., (2005) 48:16:5373	16078855

EC50	9.47		ACS Med. Chem. Lett., (2011) 2:5:368	24900318

EC50	9.44		Bioorg. Med. Chem. Lett., (2010) 20:7:2264	20188554

EC50	7.2		J. Med. Chem., (2011) 54:19:6724	21838322

S1PR4

Tclin

Sphingosine 1-phosphate receptor 4

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	9.22		J. Med. Chem., (2005) 48:16:5373	16078855

IC50	8.66		Bioorg. Med. Chem. Lett., (2012) 22:1:553	22119341

EC50	7.65		Bioorg. Med. Chem. Lett., (2010) 20:7:2264	20188554

S1PR2

Tchem

Sphingosine 1-phosphate receptor 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.23		Bioorg. Med. Chem. Lett., (2012) 22:1:553	22119341