Pharos : Ligand Details - 6NP28ZC6NB6X

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: talabostat

PubChem: 6918572

Guide to Pharmacology: 9892

ChEMBL: CHEMBL67279

LyCHI: 6NP28ZC6NB6X

Target Activities

DPP4

Tclin

Dipeptidyl peptidase 4

17 Activities

Items per page:

1 – 10 of 17

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	9.73999977			18783201

IC50	10		Bioorg. Med. Chem. Lett., (2007) 17:2:507	17055271

Ki	9.74		J. Med. Chem., (2007) 50:10:2391	17458948

Ki	9.74		J. Med. Chem., (2008) 51:19:6005	18783201

IC50	9.05		J. Med. Chem., (2013) 56:9:3467	23594271

IC50	8.82		J. Med. Chem., (2011) 54:7:2022	21388136

IC50	8.8		J. Med. Chem., (2007) 50:10:2391	17458948

IC50	8.77		None, (2015) None:None:None

Ki	8.7		Bioorg. Med. Chem. Lett., (2002) 12:20:2825	12270155

Ki	8.7		J. Med. Chem., (2004) 47:17:4135	15293982

DPP7

Tchem

Dipeptidyl peptidase 2

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.82		J. Med. Chem., (1996) 39:10:2087	8642568

IC50	7.52		Bioorg. Med. Chem. Lett., (2007) 17:2:507	17055271

IC50	7.07		Bioorg. Med. Chem. Lett., (2012) 22:10:3412	22525314

IC50	7.07		ACS Med. Chem. Lett., (2013) 4:5:491	24900696

IC50	7.07		J. Med. Chem., (2014) 57:7:3053	24617858

IC50	7.07		MedChemComm, (2014) 5:11:1700

Ki	6.9		Bioorg. Med. Chem. Lett., (2002) 12:20:2825	12270155

Ki	6.9		J. Med. Chem., (2004) 47:17:4135	15293982

PREP

Tchem

Prolyl endopeptidase

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.14		J. Med. Chem., (2013) 56:9:3467	23594271

IC50	6.01		Bioorg. Med. Chem. Lett., (2012) 22:10:3412	22525314

IC50	6.01		ACS Med. Chem. Lett., (2013) 4:5:491	24900696

IC50	6.01		J. Med. Chem., (2014) 57:7:3053	24617858

IC50	6.01		MedChemComm, (2014) 5:11:1700

IC50	6.01		J Med Chem, (2019) 62:17:7874	31393718

FAP

Tchem

Prolyl endopeptidase FAP

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.92		J. Med. Chem., (2013) 56:9:3467	23594271

IC50	7.62		Bioorg. Med. Chem. Lett., (2007) 17:2:507	17055271

IC50	7.18		J Med Chem, (2019) 62:17:7874	31393718

IC50	7.16		MedChemComm, (2014) 5:11:1700

IC50	6.65		Bioorg Med Chem Lett, (2020) 30:14:127253	32527554

DPP8

Tchem

Dipeptidyl peptidase 8

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.81999969			18783201

Ki	8.82		J. Med. Chem., (2008) 51:19:6005	18783201

IC50	8.26		J. Med. Chem., (2013) 56:9:3467	23594271

IC50	7.77		Bioorg. Med. Chem. Lett., (2007) 17:2:507	17055271

DPP9

Tchem

Dipeptidyl peptidase 9

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	9.11999989			18783201

Ki	9.12		J. Med. Chem., (2008) 51:19:6005	18783201

IC50	8.7		Bioorg. Med. Chem. Lett., (2007) 17:2:507	17055271

IC50	8.66		J. Med. Chem., (2013) 56:9:3467	23594271