Pharos : Ligand Details - 6DPN743TCGH7

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: embelin

PubChem: 3218

ChEMBL: CHEMBL221137

LyCHI: 6DPN743TCGH7

Target Activities

Explore Associated and Predicted Targets

ALOX5

Tclin

Arachidonate 5-lipoxygenase

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.22		Eur. J. Med. Chem., (2015) 94:None:132	25765759

IC50	7.22		Eur. J. Med. Chem., (2015) 94:None:132	25765759

IC50	6.1		Eur. J. Med. Chem., (2015) 94:None:132	25765759

MPEG1

Tchem

Macrophage-expressed gene 1 protein

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.68		Eur. J. Med. Chem., (2015) 94:None:132	25765759

IC50	6.68		Eur. J. Med. Chem., (2015) 94:None:132	25765759

GPR84

Tchem

G-protein coupled receptor 84

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.63		J Med Chem, (2020) 63:5:2391	31721581

EC50	7.05		J Med Chem, (2020) 63:5:2391	31721581

XIAP

Tchem

E3 ubiquitin-protein ligase XIAP

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.4		Bioorg. Med. Chem. Lett., (2006) 16:22:5805	16962773

PTGES

Tchem

Prostaglandin E synthase

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.7		Eur J Med Chem, (2018) 153:None:2	29329790