KW-2449
Ligand Summary
Name: KW-2449
PubChem: 11427553
Guide to Pharmacology: 5691
ChEMBL: CHEMBL1908397
LyCHI: 67N2T4DQ5TAN
Target Activities
FLT3
Receptor-type tyrosine-protein kinase FLT3
12 Activities
Items per page:
1 – 10 of 12
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.18 | |||||
Kd | 7.82 | |||||
Kd | 8.18 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.18 | Eur J Med Chem, (2019) 184:None:111710 | ||||
Kd | 7.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 7.88 | MedChemComm, (2012) 3:1:22 | ||||
IC50 | 7.83 | MedChemComm, (2012) 3:1:22 | ||||
Kd | 7.82 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
ABL1
Tyrosine-protein kinase ABL1
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.85 | |||||
Kd | 8.23 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.92 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.77 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.72 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.66 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.62 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
KIT
Mast/stem cell growth factor receptor Kit
3 Activities
AURKA
Aurora kinase A
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.32 | |||||
AURKB
Aurora kinase B
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.32 | |||||
YES1
Tyrosine-protein kinase Yes
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.75 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
STK16
Serine/threonine-protein kinase 16
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.54 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
STK17B
Serine/threonine-protein kinase 17B
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.32 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
STK10
Serine/threonine-protein kinase 10
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
SLK
STE20-like serine/threonine-protein kinase
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MYLK3
Myosin light chain kinase 3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.37 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
PAK2
Serine/threonine-protein kinase PAK 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.4 | Science, (2017) 358:6367:None | ||||
BMP2K
BMP-2-inducible protein kinase
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.02 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
STK17A
Serine/threonine-protein kinase 17A
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.54 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
TNIK
TRAF2 and NCK-interacting protein kinase
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.55 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MAP4K2
Mitogen-activated protein kinase kinase kinase kinase 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.96 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MINK1
Misshapen-like kinase 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.6 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
SRPK2
SRSF protein kinase 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.82 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MAP3K19
Mitogen-activated protein kinase kinase kinase 19
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.28 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Q6ZSR9
Uncharacterized protein FLJ45252
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 6.54 | Science, (2017) 358:6367:None | ||||
PLK4
Serine/threonine-protein kinase PLK4
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.68 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
OLA1
Obg-like ATPase 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.52 | Science, (2017) 358:6367:None | ||||