Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

12 Activities

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1 – 10 of 12

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.18		19541823

Kd	7.82		22037378

Kd	8.18	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.18	Eur J Med Chem, (2019) 184:None:111710	31614258

Kd	7.89	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.89	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.89	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.88	MedChemComm, (2012) 3:1:22

IC50	7.83	MedChemComm, (2012) 3:1:22

Kd	7.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

ABL1

Tclin

Tyrosine-protein kinase ABL1

7 Activities

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1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.85		19541823

Kd	8.23	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.92	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.77	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.72	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.66	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.62	Nat. Biotechnol., (2011) 29:11:1046	22037378

KIT

Tclin

Mast/stem cell growth factor receptor Kit

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.92	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.68	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.64	Nat. Biotechnol., (2011) 29:11:1046	22037378

AURKA

Tchem

Aurora kinase A

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.32			19541823

AURKB

Tchem

Aurora kinase B

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.32			19541823

YES1

Tclin

Tyrosine-protein kinase Yes

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.75		Nat. Biotechnol., (2011) 29:11:1046	22037378

STK16

Tchem

Serine/threonine-protein kinase 16

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.54		Nat. Biotechnol., (2011) 29:11:1046	22037378

STK17B

Tchem

Serine/threonine-protein kinase 17B

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.32		Nat. Biotechnol., (2011) 29:11:1046	22037378

STK10

Tchem

Serine/threonine-protein kinase 10

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.89		Nat. Biotechnol., (2011) 29:11:1046	22037378

SLK

Tchem

STE20-like serine/threonine-protein kinase

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.89		Nat. Biotechnol., (2011) 29:11:1046	22037378

MYLK3

Tchem

Myosin light chain kinase 3

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.37		Nat. Biotechnol., (2011) 29:11:1046	22037378

PAK2

Tchem

Serine/threonine-protein kinase PAK 2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.4		Science, (2017) 358:6367:None	29191878

BMP2K

Tchem

BMP-2-inducible protein kinase

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.02		Nat. Biotechnol., (2011) 29:11:1046	22037378

STK17A

Tchem

Serine/threonine-protein kinase 17A

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.54		Nat. Biotechnol., (2011) 29:11:1046	22037378

TNIK

Tchem

TRAF2 and NCK-interacting protein kinase

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.55		Nat. Biotechnol., (2011) 29:11:1046	22037378

MAP4K2

Tchem

Mitogen-activated protein kinase kinase kinase kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.96		Nat. Biotechnol., (2011) 29:11:1046	22037378

MINK1

Tchem

Misshapen-like kinase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.6		Nat. Biotechnol., (2011) 29:11:1046	22037378

SRPK2

Tchem

SRSF protein kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.82		Nat. Biotechnol., (2011) 29:11:1046	22037378

MAP3K19

Tchem

Mitogen-activated protein kinase kinase kinase 19

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.28		Nat. Biotechnol., (2011) 29:11:1046	22037378

Q6ZSR9

Tchem

Uncharacterized protein FLJ45252

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	6.54		Science, (2017) 358:6367:None	29191878

PLK4

Tchem

Serine/threonine-protein kinase PLK4

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.68		Nat. Biotechnol., (2011) 29:11:1046	22037378

OLA1

Tchem

Obg-like ATPase 1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.52		Science, (2017) 358:6367:None	29191878