Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

CNR1

Tclin

Cannabinoid receptor 1

16 Activities

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1 – 10 of 16

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.96	J. Med. Chem., (2009) 52:9:3001	19361197

Ki	7.41	J. Med. Chem., (2002) 45:17:3649	12166938

Ki	7.3	J. Med. Chem., (2005) 48:16:5059	16078824

Ki	7.3	J Med Chem, (2017) 60:1:4	27766867

Ki	7.16	J. Med. Chem., (2006) 49:7:2333	16570929

Ki	7.16	Bioorg. Med. Chem. Lett., (2006) 16:14:3765	16682198

Ki	7.16	J. Med. Chem., (2009) 52:4:1005	19161308

Ki	7.16	J. Med. Chem., (2011) 54:24:8278	22044209

Ki	7.14	Bioorg. Med. Chem. Lett., (2006) 16:1:138	16213718

Ki	7.14	J. Med. Chem., (2005) 48:23:7343	16279794

TRPV1

Tclin

Transient receptor potential cation channel subfamily V member 1

7 Activities

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1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
-	5		12761211

	5.3		10440374

-	5.9		10694225

EC50	7.8	J. Med. Chem., (2013) 56:5:1811	23384387

EC50	6.7	J. Med. Chem., (2009) 52:9:3001	19361197

EC50	6.31	J. Med. Chem., (2006) 49:7:2333	16570929

EC50	6.2	J. Med. Chem., (2013) 56:21:8224	23865723

KCNK3

Tclin

Potassium channel subfamily K member 3

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	5.6		11226154

IC50	6.15		11226154

IC50	5.52	J Med Chem, (2019) 62:22:10044	31260312

CACNA1G

Tclin

Voltage-dependent T-type calcium channel subunit alpha-1G

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	5.4			11742980

CACNA1H

Tclin

Voltage-dependent T-type calcium channel subunit alpha-1H

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	6.5			11742980

CACNA1I

Tclin

Voltage-dependent T-type calcium channel subunit alpha-1I

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	6			11742980

GLRA1

Tclin

Glycine receptor subunit alpha-1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	7.4

GPR18

Tchem

N-arachidonyl glycine receptor

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	5.42			21595653

GPR55

Tclin

G-protein coupled receptor 55

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	7.74			17876302

KCNA2

Tclin

Potassium voltage-gated channel subfamily A member 2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	5.6			8938728