CHEMBL3128069
Ligand Summary
Name: (R)-2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propane-1,2-diol
PubChem: 72710568
Guide to Pharmacology: 8137
ChEMBL: CHEMBL3128069
LyCHI: 5WS1W89CNDXT
Target Activities
ALK
ALK tyrosine kinase receptor
18 Activities
Items per page:
1 – 10 of 18
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.1 | |||||
IC50 | 9.7 | J. Med. Chem., (2014) 57:4:1170 | ||||
Ki | 9.7 | J. Med. Chem., (2014) 57:4:1170 | ||||
Ki | 9.7 | J. Med. Chem., (2014) 57:11:4720 | ||||
IC50 | 9.7 | J Med Chem, (2019) 62:24:10927 | ||||
IC50 | 9.22 | J. Med. Chem., (2014) 57:4:1170 | ||||
IC50 | 9.12 | J. Med. Chem., (2014) 57:11:4720 | ||||
IC50 | 9.1 | J. Med. Chem., (2014) 57:4:1170 | ||||
IC50 | 9.1 | J Med Chem, (2019) 62:24:10927 | ||||
IC50 | 8.89 | J. Med. Chem., (2014) 57:4:1170 | ||||
ROS1
Proto-oncogene tyrosine-protein kinase ROS
2 Activities
FER
Tyrosine-protein kinase Fer
2 Activities
FES
Tyrosine-protein kinase Fes/Fps
2 Activities
LTK
Leukocyte tyrosine kinase receptor
2 Activities
NTRK2
BDNF/NT-3 growth factors receptor
2 Activities
MAP3K9
Mitogen-activated protein kinase kinase kinase 9
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.42 | |||||
PTK2
Focal adhesion kinase 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.8 | J. Med. Chem., (2014) 57:4:1170 | ||||
NTRK1
High affinity nerve growth factor receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.77 | J. Med. Chem., (2014) 57:4:1170 | ||||
JAK2
Tyrosine-protein kinase JAK2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.92 | J. Med. Chem., (2014) 57:4:1170 | ||||
TNK2
Activated CDC42 kinase 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.82 | J. Med. Chem., (2014) 57:4:1170 | ||||
PTK2B
Protein-tyrosine kinase 2-beta
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.92 | J. Med. Chem., (2014) 57:4:1170 | ||||
NTRK3
NT-3 growth factor receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.75 | J. Med. Chem., (2014) 57:4:1170 | ||||