Pharos : Ligand Details - 5RJ14YQBJHAN

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: 4-(4-chlorophenyl)-1-(3-(4-fluorophenylthio)propyl)piperidin-4-ol

PubChem: 21533446

ChEMBL: CHEMBL1940403

LyCHI: 5RJ14YQBJHAN

Target Activities

Explore Associated and Predicted Targets

DRD2

Tclin

D(2) dopamine receptor

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.71		J Med Chem, (2019) 62:21:9488	31580666

Ki	8.68		J Med Chem, (2019) 62:21:9488	31580666

Ki	8.28		Bioorg. Med. Chem. Lett., (2014) 24:17:4294	25070422

Ki	8.06		Bioorg. Med. Chem., (2012) 20:3:1291	22245230

HTR2A

Tclin

5-hydroxytryptamine receptor 2A

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.14		Bioorg. Med. Chem., (2012) 20:3:1291	22245230

Ki	7.03		Bioorg. Med. Chem. Lett., (2014) 24:17:4294	25070422

DRD3

Tclin

D(3) dopamine receptor

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.31		Bioorg. Med. Chem., (2012) 20:3:1291	22245230

SLC6A4

Tclin

Sodium-dependent serotonin transporter

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.8		Bioorg. Med. Chem. Lett., (2014) 24:17:4294	25070422

HTR1A

Tclin

5-hydroxytryptamine receptor 1A

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.13		Bioorg. Med. Chem. Lett., (2014) 24:17:4294	25070422

SLC6A3

Tclin

Sodium-dependent dopamine transporter

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.3		Bioorg. Med. Chem. Lett., (2014) 24:17:4294	25070422

DRD1

Tclin

D(1A) dopamine receptor

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.57		Bioorg. Med. Chem. Lett., (2014) 24:17:4294	25070422