CHEMBL1980297
Ligand Summary
Name: 1-(4-(4-amino-7-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)thieno[3,2-c]pyridin-3-yl)phenyl)-3-(3-fluorophenyl)urea
PubChem: 46207586
Guide to Pharmacology: 9914
ChEMBL: CHEMBL1980297
LyCHI: 5M8MMZ4X8TGG
Target Activities
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10
1 – 10 of 15
KDR
Vascular endothelial growth factor receptor 2
9 Activities
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1 – 9 of 9
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.4 | Bioorg. Med. Chem. Lett., (2012) 22:9:3208 | ||||
IC50 | 8.52 | Bioorg. Med. Chem. Lett., (2012) 22:14:4750 | ||||
IC50 | 8.58 | None, (2014) None:None:None | ||||
IC50 | 8.58 | None, (2014) None:None:None | ||||
IC50 | 8.7 | Bioorg. Med. Chem. Lett., (2012) 22:9:3208 | ||||
IC50 | 8.7 | Bioorg. Med. Chem. Lett., (2012) 22:14:4750 | ||||
IC50 | 8.8 | None, (2014) None:None:None | ||||
IC50 | 8.8 | None, (2014) None:None:None | ||||
IC50 | 8.69999981 | |||||
AURKB
Aurora kinase B
8 Activities
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1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.1 | None, (2014) None:None:None | ||||
IC50 | 8.1 | None, (2014) None:None:None | ||||
IC50 | 8.15 | Bioorg. Med. Chem. Lett., (2012) 22:9:3208 | ||||
IC50 | 8.15 | Bioorg. Med. Chem. Lett., (2012) 22:14:4750 | ||||
IC50 | 8.17 | None, (2014) None:None:None | ||||
IC50 | 8.17 | None, (2014) None:None:None | ||||
IC50 | 8.7 | Bioorg. Med. Chem. Lett., (2012) 22:9:3208 | ||||
IC50 | 8.14999962 | |||||
CSF1R
Macrophage colony-stimulating factor 1 receptor
7 Activities
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1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.8 | Bioorg. Med. Chem. Lett., (2012) 22:9:3208 | ||||
IC50 | 8.47 | None, (2014) None:None:None | ||||
IC50 | 8.47 | None, (2014) None:None:None | ||||
Ki | 8.5 | ACS Med. Chem. Lett., (2012) 3:5:383 | ||||
IC50 | 8.65 | None, (2014) None:None:None | ||||
IC50 | 8.65 | None, (2014) None:None:None | ||||
IC50 | 8.52000046 | |||||
KIT
Mast/stem cell growth factor receptor Kit
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.56 | None, (2014) None:None:None | ||||
IC50 | 7.56 | None, (2014) None:None:None | ||||
IC50 | 7.71 | None, (2014) None:None:None | ||||
IC50 | 7.71 | None, (2014) None:None:None | ||||
IC50 | 7.69999981 | |||||
FLT3
Receptor-type tyrosine-protein kinase FLT3
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.89 | None, (2014) None:None:None | ||||
IC50 | 8.89 | None, (2014) None:None:None | ||||
IC50 | 8.95 | None, (2014) None:None:None | ||||
IC50 | 8.95 | None, (2014) None:None:None | ||||
IC50 | 9 | |||||
FLT1
Vascular endothelial growth factor receptor 1
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.68 | None, (2014) None:None:None | ||||
IC50 | 8.68 | None, (2014) None:None:None | ||||
IC50 | 8.9 | None, (2014) None:None:None | ||||
IC50 | 8.9 | None, (2014) None:None:None | ||||
IC50 | 9 | |||||
AURKA
Aurora kinase A
2 Activities
PDGFRA
Platelet-derived growth factor receptor alpha
2 Activities
PDGFRB
Platelet-derived growth factor receptor beta
2 Activities
RET
Proto-oncogene tyrosine-protein kinase receptor Ret
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.15 | Bioorg. Med. Chem. Lett., (2012) 22:9:3208 | ||||