Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

KDR

Tclin

Vascular endothelial growth factor receptor 2

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.7		22935731

Ki	9	None, None:None:None

IC50	8.8	None, (2014) None:None:None

IC50	8.7	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

IC50	8.7	Bioorg. Med. Chem. Lett., (2012) 22:14:4750	22695126

IC50	8.58	None, (2014) None:None:None

IC50	8.52	Bioorg. Med. Chem. Lett., (2012) 22:14:4750	22695126

IC50	8.4	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

AURKB

Tchem

Aurora kinase B

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.15		22935731

Ki	9.1	None, None:None:None

IC50	8.7	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

IC50	8.17	None, (2014) None:None:None

IC50	8.15	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

IC50	8.15	Bioorg. Med. Chem. Lett., (2012) 22:14:4750	22695126

IC50	8.1	None, (2014) None:None:None

CSF1R

Tclin

Macrophage colony-stimulating factor 1 receptor

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.52		22935731

IC50	8.65	None, (2014) None:None:None

Ki	8.5	None, None:None:None

Ki	8.5	ACS Med. Chem. Lett., (2012) 3:5:383	24900482

IC50	8.47	None, (2014) None:None:None

IC50	7.8	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

FLT1

Tclin

Vascular endothelial growth factor receptor 1

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	9		22935731

IC50	8.9	None, (2014) None:None:None

IC50	8.68	None, (2014) None:None:None

Ki	7.9	None, None:None:None

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	9		22935731

IC50	8.95	None, (2014) None:None:None

IC50	8.89	None, (2014) None:None:None

Ki	7.8	None, None:None:None

KIT

Tclin

Mast/stem cell growth factor receptor Kit

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.7		22935731

Ki	7.8	None, None:None:None

IC50	7.71	None, (2014) None:None:None

IC50	7.56	None, (2014) None:None:None

AURKA

Tchem

Aurora kinase A

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.92		22935731

Ki	8.7	None, None:None:None

IC50	7.92	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

PDGFRA

Tclin

Platelet-derived growth factor receptor alpha

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.96		22935731

Ki	9.1	None, None:None:None

Ki	9.1	ACS Med. Chem. Lett., (2012) 3:5:383	24900482

PDGFRB

Tclin

Platelet-derived growth factor receptor beta

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.89		22935731

Ki	9.3	None, None:None:None

IC50	8.52	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

FLT4

Tclin

Vascular endothelial growth factor receptor 3

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.37		22935731

Ki	8.5	None, None:None:None

ABL1

Tclin

Tyrosine-protein kinase ABL1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.5	None, None:None:None

IC50	7.92	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

LCK

Tclin

Tyrosine-protein kinase Lck

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.7	None, None:None:None

IC50	8.52	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.6	None, None:None:None

IC50	8.15	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

AURKC

Tchem

Aurora kinase C

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9			22935731

BLK

Tchem

Tyrosine-protein kinase Blk

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.6		None, None:None:None

KCNH2

Tclin

Potassium voltage-gated channel subfamily H member 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6		Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

MST1R

Tchem

Macrophage-stimulating protein receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8		None, None:None:None

LYN

Tclin

Tyrosine-protein kinase Lyn

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.7		None, None:None:None

IKBKE

Tchem

Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.6		None, None:None:None

MET

Tclin

Hepatocyte growth factor receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.4		None, None:None:None

SLK

Tchem

STE20-like serine/threonine-protein kinase

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.1		None, None:None:None

FRK

Tchem

Tyrosine-protein kinase FRK

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.7		None, None:None:None

TNK2

Tclin

Activated CDC42 kinase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.1		None, None:None:None

AXL

Tchem

Tyrosine-protein kinase receptor UFO

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.8		None, None:None:None

BTK

Tclin

Tyrosine-protein kinase BTK

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.6		None, None:None:None

MAP4K2

Tchem

Mitogen-activated protein kinase kinase kinase kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.1		None, None:None:None

ROS1

Tclin

Proto-oncogene tyrosine-protein kinase ROS

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.3		None, None:None:None

NTRK3

Tclin

NT-3 growth factor receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.2		None, None:None:None

LRRK2

Tchem

Leucine-rich repeat serine/threonine-protein kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.6		None, None:None:None

SRMS

Tchem

Tyrosine-protein kinase Srms

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.6		None, None:None:None

STK3

Tchem

Serine/threonine-protein kinase 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.8		None, None:None:None

NTRK2

Tclin

BDNF/NT-3 growth factors receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8		None, None:None:None

HIPK4

Tchem

Homeodomain-interacting protein kinase 4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.7		None, None:None:None

ITK

Tclin

Tyrosine-protein kinase ITK/TSK

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.9		None, None:None:None

PLK4

Tchem

Serine/threonine-protein kinase PLK4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8		None, None:None:None

NEK2

Tchem

Serine/threonine-protein kinase Nek2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.9		None, None:None:None