ilorasertib
Ligand Summary
Name: ilorasertib
PubChem: 46207586
Guide to Pharmacology: 9914
ChEMBL: CHEMBL1980297
LyCHI: 5M8MMZ4X8TGG
Target Activities
KDR
Vascular endothelial growth factor receptor 2
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.7 | |||||
Ki | 9 | None, None:None:None | ||||
IC50 | 8.8 | None, (2014) None:None:None | ||||
IC50 | 8.7 | Bioorg. Med. Chem. Lett., (2012) 22:9:3208 | ||||
IC50 | 8.7 | Bioorg. Med. Chem. Lett., (2012) 22:14:4750 | ||||
IC50 | 8.58 | None, (2014) None:None:None | ||||
IC50 | 8.52 | Bioorg. Med. Chem. Lett., (2012) 22:14:4750 | ||||
IC50 | 8.4 | Bioorg. Med. Chem. Lett., (2012) 22:9:3208 | ||||
AURKB
Aurora kinase B
7 Activities
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1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.15 | |||||
Ki | 9.1 | None, None:None:None | ||||
IC50 | 8.7 | Bioorg. Med. Chem. Lett., (2012) 22:9:3208 | ||||
IC50 | 8.17 | None, (2014) None:None:None | ||||
IC50 | 8.15 | Bioorg. Med. Chem. Lett., (2012) 22:9:3208 | ||||
IC50 | 8.15 | Bioorg. Med. Chem. Lett., (2012) 22:14:4750 | ||||
IC50 | 8.1 | None, (2014) None:None:None | ||||
CSF1R
Macrophage colony-stimulating factor 1 receptor
6 Activities
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1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.52 | |||||
IC50 | 8.65 | None, (2014) None:None:None | ||||
Ki | 8.5 | None, None:None:None | ||||
Ki | 8.5 | ACS Med. Chem. Lett., (2012) 3:5:383 | ||||
IC50 | 8.47 | None, (2014) None:None:None | ||||
IC50 | 7.8 | Bioorg. Med. Chem. Lett., (2012) 22:9:3208 | ||||
FLT1
Vascular endothelial growth factor receptor 1
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 9 | |||||
IC50 | 8.9 | None, (2014) None:None:None | ||||
IC50 | 8.68 | None, (2014) None:None:None | ||||
Ki | 7.9 | None, None:None:None | ||||
FLT3
Receptor-type tyrosine-protein kinase FLT3
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 9 | |||||
IC50 | 8.95 | None, (2014) None:None:None | ||||
IC50 | 8.89 | None, (2014) None:None:None | ||||
Ki | 7.8 | None, None:None:None | ||||
KIT
Mast/stem cell growth factor receptor Kit
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.7 | |||||
Ki | 7.8 | None, None:None:None | ||||
IC50 | 7.71 | None, (2014) None:None:None | ||||
IC50 | 7.56 | None, (2014) None:None:None | ||||
AURKA
Aurora kinase A
3 Activities
PDGFRA
Platelet-derived growth factor receptor alpha
3 Activities
PDGFRB
Platelet-derived growth factor receptor beta
3 Activities
FLT4
Vascular endothelial growth factor receptor 3
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.37 | |||||
Ki | 8.5 | None, None:None:None | ||||
ABL1
Tyrosine-protein kinase ABL1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.5 | None, None:None:None | ||||
IC50 | 7.92 | Bioorg. Med. Chem. Lett., (2012) 22:9:3208 | ||||
LCK
Tyrosine-protein kinase Lck
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.7 | None, None:None:None | ||||
IC50 | 8.52 | Bioorg. Med. Chem. Lett., (2012) 22:9:3208 | ||||
RET
Proto-oncogene tyrosine-protein kinase receptor Ret
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.6 | None, None:None:None | ||||
IC50 | 8.15 | Bioorg. Med. Chem. Lett., (2012) 22:9:3208 | ||||
AURKC
Aurora kinase C
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 9 | |||||
BLK
Tyrosine-protein kinase Blk
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.6 | None, None:None:None | ||||
KCNH2
Potassium voltage-gated channel subfamily H member 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6 | Bioorg. Med. Chem. Lett., (2012) 22:9:3208 | ||||
MST1R
Macrophage-stimulating protein receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8 | None, None:None:None | ||||
LYN
Tyrosine-protein kinase Lyn
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.7 | None, None:None:None | ||||
IKBKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.6 | None, None:None:None | ||||
MET
Hepatocyte growth factor receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.4 | None, None:None:None | ||||
SLK
STE20-like serine/threonine-protein kinase
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.1 | None, None:None:None | ||||
FRK
Tyrosine-protein kinase FRK
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.7 | None, None:None:None | ||||
TNK2
Activated CDC42 kinase 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.1 | None, None:None:None | ||||
AXL
Tyrosine-protein kinase receptor UFO
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.8 | None, None:None:None | ||||
BTK
Tyrosine-protein kinase BTK
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.6 | None, None:None:None | ||||
MAP4K2
Mitogen-activated protein kinase kinase kinase kinase 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.1 | None, None:None:None | ||||
ROS1
Proto-oncogene tyrosine-protein kinase ROS
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.3 | None, None:None:None | ||||
NTRK3
NT-3 growth factor receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.2 | None, None:None:None | ||||
LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.6 | None, None:None:None | ||||
SRMS
Tyrosine-protein kinase Srms
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.6 | None, None:None:None | ||||
STK3
Serine/threonine-protein kinase 3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.8 | None, None:None:None | ||||
NTRK2
BDNF/NT-3 growth factors receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8 | None, None:None:None | ||||
HIPK4
Homeodomain-interacting protein kinase 4
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.7 | None, None:None:None | ||||
ITK
Tyrosine-protein kinase ITK/TSK
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.9 | None, None:None:None | ||||
PLK4
Serine/threonine-protein kinase PLK4
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8 | None, None:None:None | ||||
NEK2
Serine/threonine-protein kinase Nek2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.9 | None, None:None:None | ||||