Pharos : Ligand Details

Target Activities

KDR

Tclin

Vascular endothelial growth factor receptor 2

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.4	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

IC50	8.52	Bioorg. Med. Chem. Lett., (2012) 22:14:4750	22695126

IC50	8.58	None, (2014) None:None:None

IC50	8.58	None, (2014) None:None:None

IC50	8.7	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

IC50	8.7	Bioorg. Med. Chem. Lett., (2012) 22:14:4750	22695126

IC50	8.8	None, (2014) None:None:None

IC50	8.8	None, (2014) None:None:None

IC50	8.69999981		22935731

AURKB

Tchem

Aurora kinase B

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.1	None, (2014) None:None:None

IC50	8.1	None, (2014) None:None:None

IC50	8.15	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

IC50	8.15	Bioorg. Med. Chem. Lett., (2012) 22:14:4750	22695126

IC50	8.17	None, (2014) None:None:None

IC50	8.17	None, (2014) None:None:None

IC50	8.7	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

IC50	8.14999962		22935731

CSF1R

Tclin

Macrophage colony-stimulating factor 1 receptor

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.8	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

IC50	8.47	None, (2014) None:None:None

IC50	8.47	None, (2014) None:None:None

Ki	8.5	ACS Med. Chem. Lett., (2012) 3:5:383	24900482

IC50	8.65	None, (2014) None:None:None

IC50	8.65	None, (2014) None:None:None

IC50	8.52000046		22935731

KIT

Tclin

Mast/stem cell growth factor receptor Kit

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.56	None, (2014) None:None:None

IC50	7.56	None, (2014) None:None:None

IC50	7.71	None, (2014) None:None:None

IC50	7.71	None, (2014) None:None:None

IC50	7.69999981		22935731

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.89	None, (2014) None:None:None

IC50	8.89	None, (2014) None:None:None

IC50	8.95	None, (2014) None:None:None

IC50	8.95	None, (2014) None:None:None

IC50	9		22935731

FLT1

Tclin

Vascular endothelial growth factor receptor 1

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.68	None, (2014) None:None:None

IC50	8.68	None, (2014) None:None:None

IC50	8.9	None, (2014) None:None:None

IC50	8.9	None, (2014) None:None:None

IC50	9		22935731

AURKA

Tchem

Aurora kinase A

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.92	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

IC50	6.92000008		22935731

PDGFRA

Tclin

Platelet-derived growth factor receptor alpha

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	9.1	ACS Med. Chem. Lett., (2012) 3:5:383	24900482

IC50	7.96000004		22935731

PDGFRB

Tclin

Platelet-derived growth factor receptor beta

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.52	Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

IC50	7.88999987		22935731

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.15		Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

ABL1

Tclin

Tyrosine-protein kinase ABL1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.92		Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

LCK

Tclin

Tyrosine-protein kinase Lck

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.52		Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

KCNH2

Tclin

Potassium voltage-gated channel subfamily H member 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6		Bioorg. Med. Chem. Lett., (2012) 22:9:3208	22465635

AURKC

Tchem

Aurora kinase C

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9			22935731

FLT4

Tclin

Vascular endothelial growth factor receptor 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.36999989			22935731