Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

CDK2

Tchem

Cyclin-dependent kinase 2

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.01	J. Med. Chem., (2004) 47:10:2534	15115396

IC50	8.01	J. Med. Chem., (2001) 44:25:4339	11728181

IC50	8	J. Med. Chem., (2005) 48:9:3313	15857136

IC50	8	J Med Chem, (2018) 61:20:9105	30234987

NTRK1

Tclin

High affinity nerve growth factor receptor

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.05	Bioorg. Med. Chem. Lett., (2004) 14:4:953	15013000

IC50	8.05	Eur J Med Chem, (2016) 121:None:541	27318978

Ki	7.7	None, None:None:None

GSK3B

Tclin

Glycogen synthase kinase-3 beta

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference
Ki	8.5	None, None:None:None

AC50	7.95	None, None:None:None

AC50	7.91	None, None:None:None

DYRK1A

Tchem

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.1		None, None:None:None

CDK1

Tchem

Cyclin-dependent kinase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.7		None, None:None:None

PDPK1

Tchem

3-phosphoinositide-dependent protein kinase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.8		None, None:None:None

FLT1

Tclin

Vascular endothelial growth factor receptor 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8		None, None:None:None

FLT4

Tclin

Vascular endothelial growth factor receptor 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.5		None, None:None:None

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.5		None, None:None:None

KDR

Tclin

Vascular endothelial growth factor receptor 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.6		None, None:None:None

JAK3

Tclin

Tyrosine-protein kinase JAK3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.6		None, None:None:None

FGFR3

Tclin

Fibroblast growth factor receptor 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.9		None, None:None:None

GSK3A

Tclin

Glycogen synthase kinase-3 alpha

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.4		None, None:None:None

IRAK1

Tchem

Interleukin-1 receptor-associated kinase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.7		None, None:None:None

FGFR1

Tclin

Fibroblast growth factor receptor 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.6		None, None:None:None

CLK4

Tchem

Dual specificity protein kinase CLK4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.2		None, None:None:None

STK17A

Tchem

Serine/threonine-protein kinase 17A

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.4		None, None:None:None

MELK

Tchem

Maternal embryonic leucine zipper kinase

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.2		None, None:None:None

AXL

Tchem

Tyrosine-protein kinase receptor UFO

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.7		None, None:None:None

MAP4K2

Tchem

Mitogen-activated protein kinase kinase kinase kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.1		None, None:None:None

SGK2

Tchem

Serine/threonine-protein kinase Sgk2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.8		None, None:None:None

BRSK1

Tchem

Serine/threonine-protein kinase BRSK1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.9		None, None:None:None

PKN2

Tchem

Serine/threonine-protein kinase N2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.2		None, None:None:None

PRKAA1

Tclin

5'-AMP-activated protein kinase catalytic subunit alpha-1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.4		None, None:None:None

AURKB

Tchem

Aurora kinase B

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.4		None, None:None:None

AURKA

Tchem

Aurora kinase A

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.8		None, None:None:None

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.9		None, None:None:None

PLK4

Tchem

Serine/threonine-protein kinase PLK4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.9		None, None:None:None