CHEMBL497985
Ligand Summary
Name: (6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamide
PubChem: 44580539
ChEMBL: CHEMBL497985
LyCHI: 3DFZZ439XR56
Target Activities
MMP12
Macrophage metalloelastase
2 Activities
MMP3
Stromelysin-1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.32 | ACS Med Chem Lett, (2018) 9:7:708 | ||||
MMP14
Matrix metalloproteinase-14
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.17 | ACS Med Chem Lett, (2018) 9:7:708 | ||||
ADAM17
Disintegrin and metalloproteinase domain-containing protein 17
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.21 | ACS Med Chem Lett, (2018) 9:7:708 | ||||
MMP2
72 kDa type IV collagenase
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.86 | ACS Med Chem Lett, (2018) 9:7:708 | ||||
MMP7
Matrilysin
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.12 | ACS Med Chem Lett, (2018) 9:7:708 | ||||
MMP9
Matrix metalloproteinase-9
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.98 | ACS Med Chem Lett, (2018) 9:7:708 | ||||
MMP8
Neutrophil collagenase
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.52 | ACS Med Chem Lett, (2018) 9:7:708 | ||||
MMP1
Interstitial collagenase
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.46 | ACS Med Chem Lett, (2018) 9:7:708 | ||||
ADAM10
Disintegrin and metalloproteinase domain-containing protein 10
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.01 | Bioorg. Med. Chem., (2008) 16:19:8781 | ||||