bisindolylmaleimide IX
Ligand Summary
Name: bisindolylmaleimide IX
PubChem: 5083
PubChem: 11628205
ChEMBL: CHEMBL6291
ChEMBL: CHEMBL1591531
LyCHI: 2Y4UZ3CMKA7P
Target Activities
SIRT2
NAD-dependent protein deacetylase sirtuin-2
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.1 | J. Med. Chem., (2006) 49:25:7307 | ||||
IC50 | 6.1 | J. Med. Chem., (2006) 49:25:7307 | ||||
IC50 | 6.1 | Bioorg. Med. Chem., (2011) 19:12:3669 | ||||
IC50 | 6.1 | ACS Med. Chem. Lett., (2012) 3:12:1050 | ||||
GSK3B
Glycogen synthase kinase-3 beta
3 Activities
RPS6KA3
Ribosomal protein S6 kinase alpha-3
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8 | J. Med. Chem., (2011) 54:10:3564 | ||||
PIM1
Serine/threonine-protein kinase pim-1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 8.1 | J. Med. Chem., (2005) 48:24:7604 | ||||
RPS6KA2
Ribosomal protein S6 kinase alpha-2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8 | MedChemComm, (2016) 7:2:292 | ||||
RPS6KA5
Ribosomal protein S6 kinase alpha-5
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.1 | Biochem. J., (2000) 351:1:95 | ||||
RPS6KB1
Ribosomal protein S6 kinase beta-1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.82 | Biochem. J., (2000) 351:1:95 | ||||
HIPK1
Homeodomain-interacting protein kinase 1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.44 | Eur J Med Chem, (2017) 141:None:657 | ||||