Pharos : Ligand Details

Target Activities

ABL1

Tclin

Tyrosine-protein kinase ABL1

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.4	J. Med. Chem., (2009) 52:9:2629	19320489

IC50	8.4	J. Med. Chem., (2009) 52:2:379	19143567

IC50	8	J. Med. Chem., (2009) 52:2:379	19143567

JAK2

Tclin

Tyrosine-protein kinase JAK2

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	9	J. Med. Chem., (2009) 52:9:2629	19320489

IC50	8.92	J. Med. Chem., (2009) 52:2:379	19143567

Kd	7.96	ACS Med Chem Lett, (2017) 8:6:618	28626521

FGFR1

Tclin

Fibroblast growth factor receptor 1

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8	J. Med. Chem., (2009) 52:2:379	19143567

IC50	8	J. Med. Chem., (2009) 52:2:379	19143567

Kd	7.6	Science, (2017) 358:6367:None	29191878

AURKB

Tchem

Aurora kinase B

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.57	Bioorg. Med. Chem. Lett., (2013) 23:12:3523	23664099

IC50	8.52	J. Med. Chem., (2009) 52:9:2629	19320489

Kd	7.77	Science, (2017) 358:6367:None	29191878

AURKA

Tchem

Aurora kinase A

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.52	J. Med. Chem., (2009) 52:9:2629	19320489

IC50	8.48	Bioorg. Med. Chem. Lett., (2013) 23:12:3523	23664099

Kd	7.8	Science, (2017) 358:6367:None	29191878

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8	J. Med. Chem., (2009) 52:9:2629	19320489

IC50	8	J. Med. Chem., (2009) 52:2:379	19143567

JAK3

Tclin

Tyrosine-protein kinase JAK3

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	9	J. Med. Chem., (2009) 52:9:2629	19320489

IC50	8.96	J. Med. Chem., (2009) 52:2:379	19143567

FGFR2

Tclin

Fibroblast growth factor receptor 2

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	9	J. Med. Chem., (2009) 52:2:379	19143567

IC50	8	J. Med. Chem., (2009) 52:2:379	19143567

GSK3B

Tclin

Glycogen synthase kinase-3 beta

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	9	J. Med. Chem., (2009) 52:2:379	19143567

Kd	8.15	Science, (2017) 358:6367:None	29191878

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	9	J. Med. Chem., (2009) 52:2:379	19143567

Kd	7.96	Science, (2017) 358:6367:None	29191878

RPS6KA3

Tchem

Ribosomal protein S6 kinase alpha-3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9		J. Med. Chem., (2009) 52:2:379	19143567

PRKAG2

Tchem

5'-AMP-activated protein kinase subunit gamma-2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.21		Science, (2017) 358:6367:None	29191878

FLT1

Tclin

Vascular endothelial growth factor receptor 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8		J. Med. Chem., (2009) 52:2:379	19143567

FLT4

Tclin

Vascular endothelial growth factor receptor 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9		J. Med. Chem., (2009) 52:2:379	19143567

PDGFRA

Tclin

Platelet-derived growth factor receptor alpha

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8		J. Med. Chem., (2009) 52:2:379	19143567

SRC

Tclin

Proto-oncogene tyrosine-protein kinase Src

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8		J. Med. Chem., (2009) 52:2:379	19143567

KDR

Tclin

Vascular endothelial growth factor receptor 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8		J. Med. Chem., (2009) 52:2:379	19143567

YES1

Tclin

Tyrosine-protein kinase Yes

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9		J. Med. Chem., (2009) 52:2:379	19143567

RPS6KA4

Tchem

Ribosomal protein S6 kinase alpha-4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8		J. Med. Chem., (2009) 52:2:379	19143567

FGFR3

Tclin

Fibroblast growth factor receptor 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8		J. Med. Chem., (2009) 52:2:379	19143567

GSK3A

Tclin

Glycogen synthase kinase-3 alpha

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.22		Science, (2017) 358:6367:None	29191878

AAK1

Tchem

AP2-associated protein kinase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.77		Science, (2017) 358:6367:None	29191878

PRKD1

Tchem

Serine/threonine-protein kinase D1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8		J. Med. Chem., (2009) 52:2:379	19143567

RPS6KA2

Tchem

Ribosomal protein S6 kinase alpha-2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9		J. Med. Chem., (2009) 52:2:379	19143567

TYK2

Tclin

Non-receptor tyrosine-protein kinase TYK2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9		J. Med. Chem., (2009) 52:2:379	19143567

MET

Tclin

Hepatocyte growth factor receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.15		Science, (2017) 358:6367:None