CHEMBL495727
Ligand Summary
Name: 1-Cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]urea
PubChem: 135398495
ChEMBL: CHEMBL495727
LyCHI: 25G2CWCX84YS
Target Activities
JAK3
Tyrosine-protein kinase JAK3
2 Activities
JAK2
Tyrosine-protein kinase JAK2
2 Activities
AURKA
Aurora kinase A
2 Activities
AURKB
Aurora kinase B
2 Activities
FLT3
Receptor-type tyrosine-protein kinase FLT3
2 Activities
RPS6KA3
Ribosomal protein S6 kinase alpha-3
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9 | J. Med. Chem., (2009) 52:2:379 | ||||
RPS6KA2
Ribosomal protein S6 kinase alpha-2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 9 | J. Med. Chem., (2009) 52:2:379 | ||||
GSK3B
Glycogen synthase kinase-3 beta
1 Activities
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IC50 | 9 | J. Med. Chem., (2009) 52:2:379 | ||||
FGFR2
Fibroblast growth factor receptor 2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 9 | J. Med. Chem., (2009) 52:2:379 | ||||
YES1
Tyrosine-protein kinase Yes
1 Activities
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IC50 | 9 | J. Med. Chem., (2009) 52:2:379 | ||||
RET
Proto-oncogene tyrosine-protein kinase receptor Ret
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 9 | J. Med. Chem., (2009) 52:2:379 | ||||
KDR
Vascular endothelial growth factor receptor 2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 8 | J. Med. Chem., (2009) 52:2:379 | ||||
RPS6KA4
Ribosomal protein S6 kinase alpha-4
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 8 | J. Med. Chem., (2009) 52:2:379 | ||||
PDK1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 8 | J. Med. Chem., (2009) 52:2:379 | ||||
PRKD1
Serine/threonine-protein kinase D1
1 Activities
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IC50 | 8 | J. Med. Chem., (2009) 52:2:379 | ||||
STK17A
Serine/threonine-protein kinase 17A
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 8 | J. Med. Chem., (2009) 52:2:379 | ||||
ABL1
Tyrosine-protein kinase ABL1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.4 | J. Med. Chem., (2009) 52:9:2629 | ||||
FGFR1
Fibroblast growth factor receptor 1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 8 | J. Med. Chem., (2009) 52:2:379 | ||||
TYK2
Non-receptor tyrosine-protein kinase TYK2
1 Activities
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IC50 | 9 | J. Med. Chem., (2009) 52:2:379 | ||||
MERTK
Tyrosine-protein kinase Mer
1 Activities
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IC50 | 9 | J. Med. Chem., (2009) 52:2:379 | ||||
FLT1
Vascular endothelial growth factor receptor 1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 8 | J. Med. Chem., (2009) 52:2:379 | ||||
FLT4
Vascular endothelial growth factor receptor 3
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 9 | J. Med. Chem., (2009) 52:2:379 | ||||
FGFR3
Fibroblast growth factor receptor 3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8 | J. Med. Chem., (2009) 52:2:379 | ||||