Pharos: Illuminating the Druggable Genome

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Ligand Summary

Ligand Structure

chemical structure image

Synonyms & Links

NCATS Inxight: Drugs: 11846124

Name: N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-ethoxypicolinamide

PubChem: 11846124

ChEMBL: CHEMBL424872

LyCHI: 1RB7MHGDKNRA

Target Activities

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MAPK8

Tchem

Mitogen-activated protein kinase 8

3 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.72		J. Med. Chem., (2006) 49:15:4455	16854050

IC50	7.72		Bioorg. Med. Chem. Lett., (2007) 17:2:495	17055723

IC50	8.33		ACS Med. Chem. Lett., (2012) 3:7:560	24900510

JUN

Tchem

Transcription factor AP-1

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	6.5		Bioorg. Med. Chem. Lett., (2007) 17:2:495	17055723

RPS27

Tchem

40S ribosomal protein S27

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.25		ACS Med. Chem. Lett., (2012) 3:7:560	24900510