Pharos : Ligand Details - 1L6L85TMQNYB

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: Mivebresib

PubChem: 71600087

ChEMBL: CHEMBL3987016

LyCHI: 1L6L85TMQNYB

Target Activities

Explore Associated and Predicted Targets

BRD4

Tchem

Bromodomain-containing protein 4

15 Activities

Items per page:

1 – 10 of 15

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9		Bioorg Med Chem, (2018) 26:12:3399	29764756

IC50	9		J Med Chem, (2020) 63:8:3956	32208600

Ki	8.85		None, (2016) None:None:None

Ki	8.82		J Med Chem, (2017) 60:20:8369	28949521

Ki	8.82		Bioorg Med Chem Lett, (2018) 28:10:1804	29678460

IC50	8.57		J Med Chem, (2020) 63:8:3956	32208600

Ki	8.46		None, (2016) None:None:None

Ki	7.82		Bioorg Med Chem, (2017) 25:8:2482	28314513

EC50	7.7		J Med Chem, (2017) 60:20:8369	28949521

IC50	7.7		Bioorg Med Chem Lett, (2018) 28:10:1804	29678460

EP300

Tchem

Histone acetyltransferase p300

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.2		J Med Chem, (2020) 63:8:3956	32208600

Kd	7.06		J Med Chem, (2017) 60:20:8369	28949521

P30536

Tchem

Translocator protein

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.1		J Med Chem, (2017) 60:20:8369	28949521

BRD2

Tchem

Bromodomain-containing protein 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	9		J Med Chem, (2017) 60:20:8369	28949521

BRDT

Tchem

Bromodomain testis-specific protein

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.66		J Med Chem, (2017) 60:20:8369	28949521

BRD3

Tchem

Bromodomain-containing protein 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.91		J Med Chem, (2017) 60:20:8369	28949521