Pharos : Ligand Details - 1AHT2MA4KC9V

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: sphingosine 1-phosphate

PubChem: 5283560

Guide to Pharmacology: 911

ChEMBL: CHEMBL225155

LyCHI: 1AHT2MA4KC9V

Target Activities

Explore Associated and Predicted Targets

S1PR1

Tclin

Sphingosine 1-phosphate receptor 1

21 Activities

Items per page:

1 – 10 of 21

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	8.85			17114004 14732717

EC50	10.57		Bioorg. Med. Chem. Lett., (2010) 20:7:2264	20188554

EC50	10.21		ACS Med. Chem. Lett., (2014) 5:12:1313	25516790

EC50	10		J. Med. Chem., (2010) 53:10:4198	20446681

IC50	9.8		Bioorg. Med. Chem. Lett., (2004) 14:12:3351	15149705

IC50	9.33		Bioorg. Med. Chem. Lett., (2009) 19:2:369	19081720

EC50	9.26		Bioorg. Med. Chem. Lett., (2007) 17:2:491	17070046

IC50	9.17		J. Med. Chem., (2004) 47:27:6662	15615513

IC50	9.11		Bioorg. Med. Chem. Lett., (2010) 20:8:2520	20304639

EC50	9.05		Bioorg. Med. Chem. Lett., (2003) 13:20:3401	14505636

S1PR3

Tclin

Sphingosine 1-phosphate receptor 3

19 Activities

Items per page:

1 – 10 of 19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	8.64			14732717

IC50	10.4		Bioorg. Med. Chem. Lett., (2004) 14:12:3351	15149705

EC50	9.7		J. Med. Chem., (2010) 53:10:4198	20446681

IC50	9.59		J. Med. Chem., (2004) 47:27:6662	15615513

IC50	9.4		Bioorg Med Chem Lett, (2018) 28:3:488

EC50	9.35		Bioorg. Med. Chem. Lett., (2010) 20:7:2264	20188554

IC50	9.18		Bioorg. Med. Chem. Lett., (2009) 19:2:369	19081720

EC50	9.15		J. Med. Chem., (2010) 53:10:4198	20446681

IC50	9.04		Bioorg. Med. Chem. Lett., (2010) 20:8:2520	20304639

EC50	8.96		Bioorg. Med. Chem. Lett., (2003) 13:20:3401	14505636

S1PR5

Tclin

Sphingosine 1-phosphate receptor 5

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	8.7			10799507

EC50	9.7		J. Med. Chem., (2010) 53:10:4198	20446681

IC50	9.26		J. Med. Chem., (2004) 47:27:6662	15615513

EC50	9.04		Bioorg. Med. Chem. Lett., (2007) 17:2:491	17070046

IC50	8.96		Bioorg. Med. Chem. Lett., (2009) 19:2:369	19081720

EC50	8.77		Bioorg. Med. Chem. Lett., (2004) 14:19:4903	15341948

EC50	8.74		ACS Med. Chem. Lett., (2013) 4:10:942	24900589

IC50	8.7		Bioorg. Med. Chem. Lett., (2010) 20:8:2520	20304639

IC50	8.51		Bioorg Med Chem Lett, (2018) 28:3:488

EC50	8.04		Bioorg. Med. Chem. Lett., (2003) 13:20:3401	14505636

S1PR2

Tchem

Sphingosine 1-phosphate receptor 2

11 Activities

Items per page:

1 – 10 of 11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	8.7			14732717

IC50	9.64		Bioorg. Med. Chem. Lett., (2004) 14:12:3351	15149705

IC50	9.46		J. Med. Chem., (2004) 47:27:6662	15615513

EC50	9.15		J. Med. Chem., (2010) 53:10:4198	20446681

EC50	8.89		ACS Med. Chem. Lett., (2013) 4:10:942	24900589

EC50	8.66		Bioorg. Med. Chem. Lett., (2004) 14:19:4903	15341948

EC50	8.54		Bioorg. Med. Chem. Lett., (2003) 13:20:3401	14505636

IC50	8.44		Bioorg Med Chem Lett, (2018) 28:3:488

EC50	8.08		Bioorg. Med. Chem. Lett., (2003) 13:20:3401	14505636

EC50	8.08		Bioorg. Med. Chem. Lett., (2005) 15:15:3568	15982878

S1PR4

Tclin

Sphingosine 1-phosphate receptor 4

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	7.12			14732717

IC50	8.98		Bioorg. Med. Chem. Lett., (2010) 20:8:2520	20304639

IC50	8.62		Bioorg. Med. Chem. Lett., (2009) 19:2:369	19081720

IC50	8.54		J. Med. Chem., (2010) 53:10:4198	20446681

EC50	8.1		Bioorg. Med. Chem. Lett., (2007) 17:2:491	17070046

EC50	7.89		ACS Med. Chem. Lett., (2013) 4:10:942	24900589

IC50	7.64		Bioorg. Med. Chem. Lett., (2004) 14:12:3351	15149705

IC50	7.47		J. Med. Chem., (2004) 47:27:6662	15615513

EC50	7.43		Bioorg. Med. Chem. Lett., (2004) 14:19:4903	15341948

P2RY10

Tchem

Putative P2Y purinoceptor 10

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
-	7.3			18466763