Development Level

Tbio 51 | 10,625
Tdark 14 | 7,003
Tchem 7 | 1,890
Tclin 2 | 602

IMPC Phenotype

preweaning lethality, complete... 4 | 633
embryonic lethality prior to o... 3 | 148
abnormal behavior 2 | 226
decreased body weight 2 | 174
decreased lumbar vertebrae num... 2 | 62
embryonic lethality prior to t... 2 | 187
increased sacral vertebrae num... 2 | 62
abnormal bone mineralization 1 | 55
abnormal maxilla morphology 1 | 16
abnormal retina morphology 1 | 100
abnormal tooth morphology 1 | 24
decreased Ly6C low monocyte nu... 1 | 23
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating sodium l... 1 | 18
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased rib number 1 | 59
hypoactivity 1 | 89
increased circulating alkaline... 1 | 119
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased plasma cell number 1 | 5
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

ovarian cancer 39 | 8,491
lung cancer 30 | 4,473
osteosarcoma 26 | 7,933
psoriasis 23 | 6,685
Cancer 18 | 2,346
glioblastoma 17 | 5,572
lung adenocarcinoma 15 | 2,714
Breast cancer 14 | 3,098
medulloblastoma, large-cell 14 | 6,234
Multiple myeloma 13 | 1,327
invasive ductal carcinoma 11 | 2,950
atypical teratoid / rhabdoid tumor 10 | 4,369
ductal carcinoma in situ 10 | 1,745
group 4 medulloblastoma 10 | 1,875
non-small cell lung cancer 10 | 2,798
primitive neuroectodermal tumor 10 | 3,031
breast carcinoma 9 | 1,614
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
malignant mesothelioma 9 | 3,163
pediatric high grade glioma 9 | 2,712
Photosensitive trichothiodystrophy 8 | 24
group 3 medulloblastoma 8 | 2,254
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Cockayne syndrome 7 | 54
colon cancer 7 | 1,475
ependymoma 7 | 2,514
pancreatic cancer 7 | 2,300
subependymal giant cell astrocytoma 7 | 2,287
Endometriosis 6 | 535
Pick disease 6 | 1,893
Xeroderma pigmentosum 6 | 41
astrocytoma 6 | 1,493
diabetes mellitus 6 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
posterior fossa group A ependymoma 6 | 1,511
sonic hedgehog group medulloblastoma 6 | 1,482
spina bifida 6 | 1,064
Carcinoma 5 | 2,147
Waldenstrons macroglobulinemia 5 | 764
acute myeloid leukemia 5 | 785
atypical teratoid/rhabdoid tumor 5 | 1,095
cystic fibrosis 5 | 1,670
medulloblastoma 5 | 1,524
nasopharyngeal carcinoma 5 | 1,056
non-small cell lung carcinoma 5 | 413
pilocytic astrocytoma 5 | 3,086
Peripheral Neuropathy 4 | 303
Rheumatoid Arthritis 4 | 1,170
Squamous cell carcinoma 4 | 96
acute quadriplegic myopathy 4 | 1,157
cutaneous lupus erythematosus 4 | 1,056
gastric cancer 4 | 436
oligodendroglioma 4 | 2,849
pancreatic carcinoma 4 | 567
pituitary cancer 4 | 1,972
Cleft palate 3 | 125
Connective tissue disease 3 | 59
Intellectual disability 3 | 573
Leishmaniasis 3 | 49
Lung Neoplasms 3 | 171
Lupus erythematosus 3 | 80
Mammary Neoplasms 3 | 410
Prostatic Neoplasms 3 | 471
Stomach Neoplasms 3 | 282
Treacher Collins syndrome 3 | 29
Trichothiodystrophy 1, photosensitive 3 | 4
Trichothiodystrophy Syndromes 3 | 5
adult high grade glioma 3 | 2,148
astrocytic glioma 3 | 2,241
dermatomyositis 3 | 966
hepatocellular carcinoma 3 | 550
juvenile dermatomyositis 3 | 1,189
tuberculosis 3 | 1,563
Arsenic Poisoning 2 | 59
Asthma 2 | 349
Autistic Disorder 2 | 320
Baller-Gerold syndrome 2 | 14
Cataract 2 | 104
Cocaine-Related Disorders 2 | 88
Dermatologic disorders 2 | 65
Down syndrome 2 | 548
Mandibulofacial Dysostosis 2 | 3
Neoplasm Metastasis 2 | 138
Orchitis 2 | 16
Peripheral T-cell lymphoma 2 | 24
Primary cutaneous T-cell lymphoma 2 | 29
Retinoblastoma 2 | 14
Rothmund-Thomson syndrome 2 | 22
Spinocerebellar ataxia type 7 2 | 13
Thyroiditis 2 | 25
Vaccinia 2 | 37
Werner syndrome 2 | 29
adrenocortical carcinoma 2 | 1,427
gastric carcinoma 2 | 832
glioblastoma multiforme 2 | 347
inflammatory breast cancer 2 | 404
interstitial cystitis 2 | 2,299
lung carcinoma 2 | 2,844
primary pancreatic ductal adenocarcinoma 2 | 1,271

Tissue

Female tissues 74 | 18,646
Male tissues 74 | 17,968
Blood and immune system 73 | 17,994
Cardiovascular System 73 | 17,957
Digestive Tract 73 | 18,472
Endocrine System 73 | 18,511
Nervous System 73 | 18,560
Urinary Tract 73 | 18,443
Liver and Pancreas 72 | 18,135
Respiratory system 72 | 17,483
Skin and soft tissues 66 | 18,114

Target Family

Non-IDG 36 | 11,969
Enzyme 21 | 4,146
Transcription Factor 8 | 1,400
Epigenetic 7 | 242
Kinase 2 | 634

Reactome Pathway

RNA Polymerase I Promoter Clea... 74 | 74
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase I subunit RPA1 POLR1A Tchem Enzyme -1.11653 11.6 80
Metastasis-associated protein MTA1 MTA1 Tbio Transcription Factor -2.23808 184.7 337
Histone H2B type 1-J HIST1H2BJ Tbio Non-IDG -0.54922 2.57 84
Histone H2B type 1-K HIST1H2BK Tbio Non-IDG -0.47639 3.94 20