Development Level

Tbio 105 | 11,178
Tchem 21 | 1,885
Tclin 6 | 612
Tdark 6 | 6,569

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 10 | 979
preweaning lethality, incomple... 4 | 499
embryonic lethality prior to t... 3 | 278
abnormal behavior 2 | 298
decreased body weight 2 | 161
decreased circulating insulin ... 2 | 76
embryonic lethality prior to o... 2 | 239
hypoactivity 2 | 132
increased bone mineral density 2 | 72
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
male infertility 2 | 123
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal locomotor activation 1 | 16
abnormal nail morphology 1 | 8
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal stomach morphology 1 | 10
abnormal testis morphology 1 | 43
cataract 1 | 92
corneal opacity 1 | 32
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased coping response 1 | 8
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged heart 1 | 210
hydrometra 1 | 53
hydrops fetalis 1 | 1
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating insulin ... 1 | 3
increased circulating triglyce... 1 | 42
increased exploration in new e... 1 | 8
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
limb grasping 1 | 41
mammalian phenotype 1 | 17
microphthalmia 1 | 26
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74
small testis 1 | 58
trunk curl 1 | 16

Disease

Carcinoma 109 | 11,192
ovarian cancer 85 | 8,297
medulloblastoma, large-cell 74 | 6,086
atypical teratoid / rhabdoid tumor 72 | 4,971
glioblastoma 71 | 5,635
osteosarcoma 66 | 7,766
psoriasis 63 | 6,514
lung cancer 60 | 4,607
ependymoma 57 | 4,559
group 3 medulloblastoma 48 | 4,002
Cancer 47 | 2,388
Breast cancer 44 | 3,469
lung carcinoma 43 | 2,755
malignant mesothelioma 42 | 3,135
primitive neuroectodermal tumor 42 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,902
Astrocytoma, Pilocytic 39 | 3,006
Kidney cancer 39 | 2,548
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,872
oligodendroglioma 39 | 2,768
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,204
adult high grade glioma 36 | 3,701
non-small cell lung cancer 35 | 2,799
invasive ductal carcinoma 33 | 2,867
lung adenocarcinoma 33 | 2,627
pancreatic cancer 33 | 2,322
cystic fibrosis 31 | 1,629
subependymal giant cell astrocytoma 30 | 2,230
group 4 medulloblastoma 27 | 1,806
pituitary cancer 27 | 1,915
breast carcinoma 26 | 1,589
astrocytic glioma 25 | 2,530
astrocytoma 25 | 1,113
Intellectual disability 24 | 998
interstitial cystitis 24 | 2,237
Short stature 23 | 514
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,911
tuberculosis 22 | 1,963
Pick disease 21 | 1,856
ulcerative colitis 20 | 1,765
colon cancer 19 | 1,428
ductal carcinoma in situ 19 | 1,686
pediatric high grade glioma 19 | 1,035
adrenocortical carcinoma 18 | 1,385
Dull intelligence 17 | 634
Low intelligence 17 | 634
Mental Retardation 17 | 634
Mental deficiency 17 | 634
Poor school performance 17 | 634
Schizophrenia 17 | 1,136
Autosomal recessive predisposition 16 | 1,407
Cryptorchidism 16 | 287
cutaneous lupus erythematosus 16 | 1,016
Cognitive delay 15 | 596
Global developmental delay 15 | 596
Mental and motor retardation 15 | 596
Liver cancer 14 | 589
Melanoma 14 | 689
Small head 14 | 366
Bipolar Disorder 13 | 646
Cleft Lip 13 | 141
Cleft Palate 13 | 265
Hypoplastic mandible condyle 13 | 273
Mandibular hypoplasia 13 | 273
Micrognathism 13 | 273
Orbital separation excessive 13 | 240
diabetes mellitus 13 | 1,683
esophageal adenocarcinoma 13 | 696
Epilepsy 12 | 775
Muscle hypotonia 12 | 562
active ulcerative colitis 12 | 736
primary Sjogren syndrome 12 | 710
Liver Cirrhosis, Experimental 11 | 733
Multiple myeloma 11 | 1,296
Rheumatoid arthritis 11 | 1,156
Strabismus 11 | 265
acute quadriplegic myopathy 11 | 1,133
Alzheimer's disease 10 | 640
Autistic Disorder 10 | 358
Blepharoptosis 10 | 229
Craniofacial Abnormalities 10 | 141
Seizures 10 | 584
medulloblastoma 10 | 702
Failure to gain weight 9 | 359
Fetal Growth Retardation 9 | 186
Hypotrophic malar bone 9 | 129
Infant, Small for Gestational Age 9 | 174
Intrauterine retardation 9 | 174
Low set ears 9 | 178
Malar flattening 9 | 129
Pediatric failure to thrive 9 | 359
Prostatic Neoplasms 9 | 472
Stomach Neoplasms 9 | 287
Ventricular Septal Defects 9 | 113
dermatomyositis 9 | 941
juvenile dermatomyositis 9 | 1,147
posterior fossa group A ependymoma 9 | 456
spina bifida 9 | 1,053
Abnormally small eyeball 8 | 94
Decreased size of eyeball 8 | 94

Tissue

Endocrine System 137 | 18,159
Digestive Tract 136 | 17,369
Female tissues 136 | 17,400
Liver and Pancreas 135 | 16,750
Respiratory system 135 | 16,393
Urinary Tract 135 | 16,678
Male tissues 134 | 17,142
Nervous System 134 | 16,725
Skin and soft tissues 134 | 17,230
Blood and immune system 133 | 16,909
Cardiovascular System 126 | 15,192

Target Family

Non-IDG 65 | 12,091
Transcription Factor 32 | 1,400
Enzyme 20 | 4,145
Kinase 7 | 634
Epigenetic 5 | 242
GPCR 4 | 408
Ion Channel 2 | 344
Nuclear Receptor 2 | 48
Transporter 1 | 473

WikiPathways Pathway

Ectoderm Differentiation 138 | 138
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nuclear mitotic apparatus protein 1 NUMA1 Tbio Non-IDG -2.76544 575.8 235
BCL-6 corepressor BCOR Tbio Non-IDG -2.04681 115.7 157
Ankyrin repeat and sterile alpha motif domain-containing protein 1B ANKS1B Tbio Non-IDG -1.29634 23.1 106
Four and a half LIM domains protein 2 FHL2 Tbio Non-IDG -2.60042 385.8 253
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.26513 1878.2 658
TSC22 domain family protein 1 TSC22D1 Tbio Transcription Factor -1.54599 46.0 300
GRAM domain-containing protein 1B GRAMD1B Tdark Non-IDG -0.37654 2.90 39
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.76391 516.8 355
Histone lysine demethylase PHF8 PHF8 Tchem Epigenetic -1.50422 40.0 77
Myeloid zinc finger 1 MZF1 Tbio Transcription Factor -1.89490 73.2 89