Development Level

Tbio 55 | 10,625
Tdark 14 | 7,003
Tchem 10 | 1,890

IMPC Term

preweaning lethality, complete... 5 | 633
abnormal retina morphology 3 | 100
abnormal lens morphology 2 | 73
abnormal skin morphology 2 | 23
abnormal spleen morphology 2 | 36
decreased bone mineral density 2 | 126
embryonic lethality prior to o... 2 | 148
increased circulating HDL chol... 2 | 63
abnormal autopod morphology 1 | 1
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coat/hair pigmentatio... 1 | 54
abnormal cranium morphology 1 | 32
abnormal digit morphology 1 | 13
abnormal eye morphology 1 | 38
abnormal heart left ventricle ... 1 | 20
abnormal joint morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal maxilla morphology 1 | 16
abnormal motor capabilities/co... 1 | 4
abnormal nail morphology 1 | 7
abnormal optic disc morphology 1 | 10
abnormal retinal pigmentation 1 | 61
abnormal skin coloration 1 | 18
abnormal spine curvature 1 | 7
abnormal stomach morphology 1 | 4
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
abnormal thoracic vertebrae mo... 1 | 16
abnormal tibia morphology 1 | 14
abnormal vertebrae morphology 1 | 14
abnormal vocalization 1 | 21
aorta stenosis 1 | 1
brachydactyly 1 | 2
cataract 1 | 26
decreased CD5-positive gamma-d... 1 | 3
decreased alpha-beta T cell nu... 1 | 12
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased cardiac stroke volum... 1 | 3
decreased circulating chloride... 1 | 32
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased erythrocyte cell num... 1 | 43
decreased gamma-delta T cell n... 1 | 18
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased kidney weight 1 | 7
decreased lean body mass 1 | 195
decreased rib number 1 | 59
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
fusion of vertebral arches 1 | 7
hypoactivity 1 | 89
increased bone mineral content 1 | 92
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128
increased prepulse inhibition 1 | 21
kinked tail 1 | 3
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
short tail 1 | 4
short tibia 1 | 82
small testis 1 | 37
straub tail 1 | 26
tremors 1 | 34
vertebral fusion 1 | 23

Disease

osteosarcoma 45 | 7,933
ovarian cancer 35 | 8,484
psoriasis 28 | 6,685
medulloblastoma, large-cell 26 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
lung cancer 20 | 4,466
glioblastoma 17 | 5,572
Breast cancer 16 | 3,094
Cancer 16 | 2,346
atypical teratoid / rhabdoid tumor 15 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,988
group 3 medulloblastoma 14 | 2,254
malignant mesothelioma 14 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
invasive ductal carcinoma 12 | 2,950
colon cancer 10 | 1,475
lung adenocarcinoma 10 | 2,713
pancreatic cancer 10 | 2,300
primitive neuroectodermal tumor 10 | 3,031
astrocytic glioma 9 | 2,241
non-small cell lung cancer 9 | 2,798
Waldenstrons macroglobulinemia 8 | 765
group 4 medulloblastoma 8 | 1,875
pancreatic carcinoma 8 | 567
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
pilocytic astrocytoma 8 | 3,086
ulcerative colitis 8 | 2,087
Atopic dermatitis 7 | 944
Carcinoma 7 | 2,147
adrenocortical carcinoma 7 | 1,427
astrocytoma 7 | 1,493
non primary Sjogren syndrome sicca 7 | 840
oligodendroglioma 7 | 2,849
pediatric high grade glioma 7 | 2,712
subependymal giant cell astrocytoma 7 | 2,287
Fanconi's anemia 6 | 50
Multiple myeloma 6 | 1,327
hepatocellular carcinoma 6 | 532
interstitial cystitis 6 | 2,299
nasopharyngeal carcinoma 6 | 1,056
posterior fossa group B ependymoma 6 | 1,530
tuberculosis 6 | 1,557
Cockayne syndrome 5 | 54
Prostatic Neoplasms 5 | 471
Rheumatoid Arthritis 5 | 1,160
Xeroderma pigmentosum 5 | 41
adult high grade glioma 5 | 2,148
ductal carcinoma in situ 5 | 1,745
gastric cancer 5 | 430
lung carcinoma 5 | 2,844
posterior fossa group A ependymoma 5 | 1,511
sonic hedgehog group medulloblastoma 5 | 1,482
Bloom syndrome 4 | 30
IGA Glomerulonephritis 4 | 454
Peripheral Neuropathy 4 | 303
Pick disease 4 | 1,893
breast carcinoma 4 | 1,614
diabetes mellitus 4 | 1,663
pituitary cancer 4 | 1,972
primary Sjogren syndrome 4 | 789
tuberculosis and treatment for 6 months 4 | 686
Aicardi-Goutieres syndrome 3 | 18
Crohn's disease 3 | 304
Endometriosis 3 | 535
Neoplasm Metastasis 3 | 138
Photosensitive trichothiodystrophy 3 | 24
Seckel syndrome 3 | 34
acute myeloid leukemia 3 | 780
acute quadriplegic myopathy 3 | 1,157
aldosterone-producing adenoma 3 | 664
cutaneous lupus erythematosus 3 | 1,056
cystic fibrosis 3 | 1,665
dermatomyositis 3 | 933
inflammatory breast cancer 3 | 404
medulloblastoma 3 | 1,524
progressive supranuclear palsy 3 | 674
spina bifida 3 | 1,064
Allergic hypersensitivity disease 2 | 123
Allergic rhinitis 2 | 91
Alzheimer's disease 2 | 644
Amyotrophic Lateral Sclerosis 2 | 431
Chronic progressive external ophthalmoplegia 2 | 18
Eosinophilia 2 | 65
Lung disease 2 | 132
Neurodegenerative disease 2 | 383
Prostate cancer 2 | 172
Severe Combined Immunodeficiency 2 | 46
Stomach Neoplasms 2 | 282
active Crohn's disease 2 | 918
atypical teratoid/rhabdoid tumor 2 | 1,095
ependymoma 2 | 2,514
fibroadenoma 2 | 557
head and neck cancer and chronic obstructive pulmonary disease 2 | 237
hereditary spastic paraplegia 2 | 313
juvenile dermatomyositis 2 | 1,189
mucosa-associated lymphoid tissue lymphoma 2 | 480
nephrosclerosis 2 | 329
non-small cell lung carcinoma 2 | 413
primary pancreatic ductal adenocarcinoma 2 | 1,271
systemic lupus erythematosus 2 | 156

Tissue

Cardiovascular System 69 | 17,958
Endocrine System 69 | 18,512
Nervous System 69 | 18,561
Blood and immune system 68 | 17,995
Digestive Tract 68 | 18,473
Liver and Pancreas 68 | 18,136
Male tissues 68 | 17,969
Skin and soft tissues 68 | 18,115
Urinary Tract 68 | 18,444
Female tissues 67 | 18,647
Respiratory system 67 | 17,484

Target Family

Enzyme 65 | 4,146
Non-IDG 12 | 11,971
Epigenetic 1 | 242
Kinase 1 | 634

UniProt Keyword

Endonuclease 79 | 79
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein SLFN14 SLFN14 Tbio Non-IDG -0.46133 3.23 50
Mitochondrial cardiolipin hydrolase PLD6 Tbio Enzyme -1.27608 22.1 43
Ribonuclease 8 RNASE8 Tbio Enzyme -0.84510 9.01 54
Ribonuclease T2 RNASET2 Tbio Enzyme -1.58109 34.3 122
Ribonuclease 3 DROSHA Tbio Enzyme -2.51389 289.6 180
Ribonuclease H1 RNASEH1 Tchem Enzyme -1.06119 9.78 69
Probable ribonuclease ZC3H12B ZC3H12B Tdark Enzyme -0.31527 1.47 69
Ras GTPase-activating protein-binding protein 1 G3BP1 Tbio Enzyme -1.97101 103.6 402
Zinc phosphodiesterase ELAC protein 2 ELAC2 Tbio Enzyme -1.76186 57.7 108
2-5A-dependent ribonuclease RNASEL Tchem Kinase -2.67894 493.8 111