Development Level

Tbio 547 | 11,178
Tchem 83 | 1,885
Tdark 33 | 6,569
Tclin 9 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 57 | 979
preweaning lethality, incomple... 21 | 499
embryonic lethality prior to t... 20 | 278
abnormal embryo size 15 | 220
abnormal bone structure 13 | 187
embryonic lethality prior to o... 13 | 239
abnormal behavior 12 | 298
decreased vertical activity 12 | 208
increased lean body mass 12 | 172
decreased total body fat amoun... 11 | 207
increased total body fat amoun... 10 | 134
decreased body weight 9 | 161
enlarged heart 9 | 210
increased or absent threshold ... 9 | 101
decreased circulating triglyce... 8 | 79
increased bone mineral content 8 | 108
increased mean corpuscular vol... 8 | 92
male infertility 8 | 123
abnormal heart morphology 7 | 162
abnormal retina morphology 7 | 71
decreased bone mineral density 7 | 126
decreased circulating glucose ... 7 | 126
decreased lean body mass 7 | 135
embryonic growth retardation 7 | 106
increased bone mineral density 7 | 72
increased circulating alkaline... 7 | 122
short tibia 7 | 97
thrombocytopenia 7 | 56
abnormal bone mineralization 6 | 38
abnormal seminal vesicle morph... 6 | 114
abnormal sleep behavior 6 | 70
decreased caudal vertebrae num... 6 | 53
decreased circulating choleste... 6 | 93
decreased erythrocyte cell num... 6 | 62
improved glucose tolerance 6 | 79
increased mean corpuscular hem... 6 | 96
abnormal eye morphology 5 | 68
decreased T cell number 5 | 15
decreased bone mineral content 5 | 151
decreased circulating serum al... 5 | 82
decreased leukocyte cell numbe... 5 | 73
decreased mean corpuscular vol... 5 | 79
decreased prepulse inhibition 5 | 82
hypoactivity 5 | 132
increased circulating choleste... 5 | 66
prenatal lethality prior to he... 5 | 87
abnormal cornea morphology 4 | 31
abnormal gait 4 | 69
abnormal kidney morphology 4 | 65
abnormal neural tube closure 4 | 46
decreased CD4-positive, alpha ... 4 | 7
decreased circulating calcium ... 4 | 36
decreased circulating creatini... 4 | 39
decreased circulating insulin ... 4 | 76
female infertility 4 | 60
impaired glucose tolerance 4 | 75
increased B cell number 4 | 9
increased circulating sodium l... 4 | 71
increased circulating triglyce... 4 | 42
increased fasted circulating g... 4 | 76
increased heart weight 4 | 62
increased startle reflex 4 | 112
small superior vagus ganglion 4 | 74
abnormal embryo turning 3 | 31
abnormal forebrain development 3 | 20
abnormal spleen morphology 3 | 55
abnormal tooth morphology 3 | 24
abnormal vertebrae morphology 3 | 18
cataract 3 | 92
decreased IgG1 level 3 | 8
decreased blood urea nitrogen ... 3 | 51
decreased body length 3 | 101
decreased circulating HDL chol... 3 | 68
decreased circulating amylase ... 3 | 28
decreased circulating fructosa... 3 | 30
decreased hematocrit 3 | 46
decreased hemoglobin content 3 | 68
decreased startle reflex 3 | 75
hydrometra 3 | 53
hyperactivity 3 | 148
increased circulating HDL chol... 3 | 80
increased circulating aspartat... 3 | 15
increased circulating chloride... 3 | 41
increased circulating creatine... 3 | 5
increased hemoglobin content 3 | 45
increased lactate dehydrogenas... 3 | 3
increased monocyte cell number 3 | 63
mammalian phenotype 3 | 17
microphthalmia 3 | 26
abnormal coat-hair pigmentatio... 2 | 64
abnormal head morphology 2 | 10
abnormal placenta size 2 | 20
anophthalmia 2 | 33
corneal opacity 2 | 32
decreased circulating LDL chol... 2 | 38
decreased eosinophil cell numb... 2 | 24
decreased neutrophil cell numb... 2 | 42
enlarged spleen 2 | 41
increased circulating serum al... 2 | 22
small testis 2 | 58

Disease

Carcinoma 451 | 11,192
ovarian cancer 351 | 8,297
osteosarcoma 333 | 7,766
psoriasis 265 | 6,514
medulloblastoma, large-cell 255 | 6,086
glioblastoma 216 | 5,635
lung cancer 214 | 4,607
Cancer 202 | 2,388
atypical teratoid / rhabdoid tumor 192 | 4,971
group 3 medulloblastoma 189 | 4,002
Breast cancer 173 | 3,469
ependymoma 160 | 4,559
malignant mesothelioma 160 | 3,135
primitive neuroectodermal tumor 126 | 2,957
intraductal papillary-mucinous neoplasm (IPMN) 125 | 3,204
invasive ductal carcinoma 125 | 2,867
Kidney cancer 124 | 2,548
intraductal papillary-mucinous carcinoma (IPMC) 113 | 2,902
oligodendroglioma 112 | 2,768
adult high grade glioma 106 | 3,701
intraductal papillary-mucinous adenoma (IPMA) 103 | 2,872
lung carcinoma 100 | 2,755
pancreatic cancer 100 | 2,322
non-small cell lung cancer 93 | 2,799
pituitary cancer 92 | 1,915
astrocytic glioma 91 | 2,530
lung adenocarcinoma 90 | 2,627
subependymal giant cell astrocytoma 88 | 2,230
Astrocytoma, Pilocytic 86 | 3,006
ulcerative colitis 85 | 1,765
Pick disease 84 | 1,856
astrocytoma 84 | 1,113
breast carcinoma 82 | 1,589
ductal carcinoma in situ 81 | 1,686
interstitial cystitis 79 | 2,237
group 4 medulloblastoma 77 | 1,806
Rheumatoid arthritis 76 | 1,156
diabetes mellitus 76 | 1,683
juvenile dermatomyositis 74 | 1,147
acute quadriplegic myopathy 71 | 1,133
Intellectual disability 69 | 998
tuberculosis 68 | 1,963
Multiple myeloma 66 | 1,296
dermatomyositis 64 | 941
pancreatic ductal adenocarcinoma liver metastasis 64 | 1,911
cystic fibrosis 60 | 1,629
Schizophrenia 59 | 1,136
colon cancer 56 | 1,428
pediatric high grade glioma 56 | 1,035
spina bifida 56 | 1,053
adrenocortical carcinoma 54 | 1,385
primary pancreatic ductal adenocarcinoma 53 | 1,071
acute myeloid leukemia 49 | 760
Obesity 48 | 655
Breast Neoplasms 46 | 423
Autosomal recessive predisposition 45 | 1,407
Bipolar Disorder 44 | 646
Dull intelligence 44 | 634
Low intelligence 44 | 634
Mental Retardation 44 | 634
Mental deficiency 44 | 634
Poor school performance 44 | 634
Mammary Neoplasms 43 | 403
aldosterone-producing adenoma 40 | 646
cutaneous lupus erythematosus 40 | 1,016
Prostatic Neoplasms 39 | 472
Waldenstrons macroglobulinemia 39 | 742
gastric carcinoma 39 | 781
autosomal dominant Emery-Dreifuss muscular dystrophy 38 | 492
primary Sjogren syndrome 38 | 710
Short stature 36 | 514
Alzheimer's disease 35 | 640
Atopic dermatitis 35 | 915
Cognitive delay 35 | 596
Global developmental delay 35 | 596
Liver cancer 35 | 589
Mental and motor retardation 35 | 596
Muscle hypotonia 33 | 562
nasopharyngeal carcinoma 32 | 1,024
Endometriosis 31 | 521
Acquired metabolic disease 30 | 329
Amyotrophic lateral sclerosis 30 | 437
medulloblastoma 30 | 702
non primary Sjogren syndrome sicca 30 | 861
Epilepsy 29 | 775
Melanoma 29 | 689
fibroadenoma 29 | 538
Cryptorchidism 27 | 287
Carcinoma, Hepatocellular 26 | 217
Liver carcinoma 26 | 229
Seizures 26 | 584
active ulcerative colitis 26 | 736
progressive supranuclear palsy 26 | 656
Multiple Sclerosis 25 | 527
Strabismus 25 | 265
active Crohn's disease 25 | 882
esophageal adenocarcinoma 25 | 696
hepatocellular carcinoma 25 | 536
tuberculosis and treatment for 6 months 25 | 399
Cleft Palate 24 | 265

Tissue

Endocrine System 651 | 18,159
Digestive Tract 641 | 17,369
Skin and soft tissues 640 | 17,230
Female tissues 630 | 17,400
Nervous System 627 | 16,725
Male tissues 625 | 17,142
Liver and Pancreas 623 | 16,750
Blood and immune system 617 | 16,909
Urinary Tract 612 | 16,678
Respiratory system 604 | 16,393
Cardiovascular System 574 | 15,192

Target Family

Transcription Factor 360 | 1,400
Non-IDG 185 | 12,091
Enzyme 51 | 4,145
Epigenetic 37 | 242
Nuclear Receptor 23 | 48
Kinase 8 | 634
TF/Epigenetic 7 | 38
Transporter 1 | 473

UniProt Keyword

Activator 672 | 672
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability