Development Level

Tbio 29 | 10,625
Tchem 22 | 1,890
Tclin 12 | 602
Tdark 2 | 7,003

IMPC Phenotype

abnormal bone structure 2 | 131
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 85
decreased lean body mass 2 | 195
decreased mean platelet volume 2 | 12
decreased total body fat amoun... 2 | 186
improved glucose tolerance 2 | 56
increased circulating HDL chol... 2 | 63
increased circulating alkaline... 2 | 119
increased circulating choleste... 2 | 53
small kidney 2 | 10
abnormal behavior 1 | 226
abnormal clavicle morphology 1 | 5
abnormal coat appearance 1 | 25
abnormal coat- hair morphology 1 | 18
abnormal cranium morphology 1 | 32
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal heart left ventricle ... 1 | 20
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal pelvic girdle bone mo... 1 | 11
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal scapula morphology 1 | 3
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
absent mammary gland 1 | 1
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased cervical vertebrae n... 1 | 12
decreased circulating HDL chol... 1 | 77
decreased circulating calcium ... 1 | 33
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating phosphat... 1 | 15
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart rate 1 | 10
decreased heart weight 1 | 44
decreased leukocyte cell numbe... 1 | 54
decreased skeletal muscle mass 1 | 1
decreased vertical activity 1 | 22
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 29
increased circulating serum al... 1 | 25
increased circulating triglyce... 1 | 24
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased lactate dehydrogenas... 1 | 3
increased respiratory quotient 1 | 12
increased total body fat amoun... 1 | 57
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
shortened QRS complex duration 1 | 1
small heart 1 | 8
small ovary 1 | 1
small spleen 1 | 11
small uterus 1 | 1
thin skin 1 | 1

Disease

psoriasis 32 | 6,685
Cancer 24 | 2,346
ovarian cancer 23 | 8,491
medulloblastoma, large-cell 22 | 6,234
osteosarcoma 22 | 7,933
lung cancer 20 | 4,473
Prostatic Neoplasms 17 | 471
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,795
interstitial cystitis 16 | 2,299
glioblastoma 15 | 5,572
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
atypical teratoid / rhabdoid tumor 13 | 4,369
lung carcinoma 13 | 2,844
malignant mesothelioma 12 | 3,163
non-small cell lung cancer 12 | 2,798
Breast cancer 11 | 3,098
Congenital adrenal hyperplasia 11 | 74
Liver disease 11 | 219
Hypertension 10 | 293
adrenocortical carcinoma 10 | 1,427
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
Mammary Neoplasms 9 | 410
pituitary cancer 9 | 1,972
tuberculosis 9 | 1,563
Drug-Induced Liver Injury 8 | 118
cystic fibrosis 8 | 1,670
diabetes mellitus 8 | 1,663
group 4 medulloblastoma 8 | 1,875
lung adenocarcinoma 8 | 2,714
pancreatic cancer 8 | 2,300
pediatric high grade glioma 8 | 2,712
pilocytic astrocytoma 8 | 3,086
ulcerative colitis 8 | 2,087
Cholestasis 7 | 93
Peripheral Neuropathy 7 | 303
adult high grade glioma 7 | 2,148
ductal carcinoma in situ 7 | 1,745
invasive ductal carcinoma 7 | 2,950
Adenoma 6 | 165
Endometriosis 6 | 535
Lung Neoplasms 6 | 171
Obesity 6 | 616
Schizophrenia 6 | 503
active Crohn's disease 6 | 918
aldosterone-producing adenoma 6 | 664
astrocytoma 6 | 1,493
chronic rhinosinusitis 6 | 512
cutaneous lupus erythematosus 6 | 1,056
group 3 medulloblastoma 6 | 2,254
oligodendroglioma 6 | 2,849
posterior fossa group A ependymoma 6 | 1,511
Adenocarcinoma 5 | 115
Adrenal cortical adenoma 5 | 10
Antley-Bixler syndrome 5 | 15
Cardiomegaly 5 | 66
Cushing's syndrome 5 | 47
Hyperandrogenism 5 | 32
Pick disease 5 | 1,893
Polycystic Ovary Syndrome 5 | 334
breast carcinoma 5 | 1,614
primary pancreatic ductal adenocarcinoma 5 | 1,271
substance-related disorder 5 | 104
Adverse reaction to drug 4 | 54
Amenorrhea 4 | 60
Atopic dermatitis 4 | 944
Candidiasis of mouth 4 | 5
Candidiasis of skin 4 | 6
Cerebrotendinous xanthomatosis 4 | 12
Colorectal Neoplasms 4 | 217
Congenital adrenal insufficiency 4 | 7
Conn's syndrome 4 | 22
Epilepsy 4 | 346
Fatty Liver 4 | 48
Fatty liver disease 4 | 86
Human immunodeficiency virus infection 4 | 6
Hypogonadism 4 | 70
Hypokalemia 4 | 40
Infertility 4 | 163
Kidney disease 4 | 397
Liver carcinoma 4 | 217
Liver diseases 4 | 66
Male infertility 4 | 170
Pityriasis versicolor 4 | 18
Precursor Cell Lymphoblastic Leukemia Lymphoma 4 | 42
Pseudohermaphroditism 4 | 16
Rheumatoid Arthritis 4 | 1,170
Spontaneous abortion 4 | 108
Tinea corporis 4 | 25
Tinea cruris 4 | 12
Tinea pedis 4 | 30
acute quadriplegic myopathy 4 | 1,157
astrocytic glioma 4 | 2,241
gastric carcinoma 4 | 832
medulloblastoma 4 | 1,524
nephrosclerosis 4 | 329
primitive neuroectodermal tumor 4 | 3,031
Alzheimer's disease 3 | 644
Contact Dermatitis 3 | 80
nasopharyngeal carcinoma 3 | 1,056

Tissue

Digestive Tract 65 | 18,472
Endocrine System 65 | 18,511
Female tissues 65 | 18,646
Liver and Pancreas 65 | 18,135
Nervous System 65 | 18,560
Skin and soft tissues 65 | 18,114
Urinary Tract 65 | 18,443
Blood and immune system 64 | 17,994
Cardiovascular System 64 | 17,957
Male tissues 63 | 17,968
Respiratory system 63 | 17,483

Target Family

Non-IDG 31 | 11,969
Enzyme 28 | 4,146
Transcription Factor 3 | 1,400
Nuclear Receptor 2 | 48
Epigenetic 1 | 242

Reactome Pathway

Cytochrome P450 - arranged by ... 65 | 65
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bile acid receptor NR1H4 Tclin Nuclear Receptor -2.52741 306.4 272
Cytochrome P450 4A11 CYP4A11 Tbio Non-IDG -1.95512 88.7 122
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.82645 66.0 151
Phylloquinone omega-hydroxylase CYP4F2 CYP4F2 Tbio Enzyme -2.12070 135.1 75
Cytochrome P450 3A43 CYP3A43 Tclin Enzyme -1.20317 14.6 66