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  3. nucleic acid binding
  4. RNA binding protein
  5. mRNA processing factor
  6. mRNA splicing factor
Target Filters...

Development Level

Tbio 86 | 11,651
Tdark 19 | 6,593
Tchem 2 | 1,388

IMPC Phenotype

preweaning lethality, complete... 10 | 979
abnormal behavior 5 | 298
hyperactivity 3 | 148
cataract 2 | 92
decreased grip strength 2 | 116
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
hypoactivity 2 | 132
increased circulating creatini... 2 | 38
increased or absent threshold ... 2 | 101
preweaning lethality, incomple... 2 | 499
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal lens morphology 1 | 81
abnormal neural tube morpholog... 1 | 12
abnormal sleep behavior 1 | 70
aorta dilation 1 | 3
decreased IgE level 1 | 6
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased heart left ventricle... 1 | 28
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic lethality prior to t... 1 | 278
impaired righting response 1 | 26
increased basophil cell number 1 | 7
increased circulating alkaline... 1 | 122
increased circulating phosphat... 1 | 26
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased mean corpuscular hem... 1 | 36
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
short tibia 1 | 97
thin ventricular wall 1 | 24

Disease

Carcinoma 65 | 11,493
ovarian cancer 60 | 8,520
osteosarcoma 53 | 7,950
psoriasis 43 | 6,694
group 3 medulloblastoma 39 | 4,104
medulloblastoma, large-cell 39 | 6,241
glioblastoma 33 | 5,792
atypical teratoid / rhabdoid tumor 30 | 5,112
ependymoma 30 | 4,679
lung cancer 30 | 4,740
malignant mesothelioma 26 | 3,232
Multiple myeloma 24 | 1,332
oligodendroglioma 23 | 2,850
primitive neuroectodermal tumor 22 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
Pick disease 20 | 1,894
Breast cancer 18 | 3,578
astrocytic glioma 17 | 2,597
acute quadriplegic myopathy 16 | 1,158
adult high grade glioma 16 | 3,801
Kidney cancer 15 | 2,613
dermatomyositis 15 | 966
diabetes mellitus 15 | 1,728
non-small cell lung cancer 15 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
lung adenocarcinoma 14 | 2,716
Cancer 13 | 2,499
astrocytoma 13 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
progressive supranuclear palsy 12 | 676
Waldenstrons macroglobulinemia 11 | 765
breast carcinoma 11 | 1,638
invasive ductal carcinoma 11 | 2,951
subependymal giant cell astrocytoma 11 | 2,287
pancreatic cancer 10 | 2,398
Astrocytoma, Pilocytic 9 | 3,081
Intellectual disability 9 | 1,016
Gaucher disease type 1 8 | 180
group 4 medulloblastoma 8 | 1,855
Dull intelligence 7 | 645
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Rheumatoid arthritis 7 | 1,191
hepatocellular carcinoma 7 | 547
lung carcinoma 7 | 2,843
non primary Sjogren syndrome sicca 7 | 891
pituitary cancer 7 | 1,972
Conductive hearing loss 6 | 123
Glaucoma 6 | 239
HIV Infections 6 | 102
Obesity 6 | 678
Schizophrenia 6 | 1,160
aldosterone-producing adenoma 6 | 665
colon cancer 6 | 1,478
sonic hedgehog group medulloblastoma 6 | 467
Abnormality of retinal pigmentation 5 | 111
Abnormality of the retinal vasculature 5 | 59
Anteverted nostril 5 | 191
Atypical scarring of skin 5 | 62
Blind Vision 5 | 111
Blindness, Legal 5 | 110
Broad flat nasal bridge 5 | 236
Cataract 5 | 297
Congenital anomaly of testis 5 | 52
Congenital hypoplasia of penis 5 | 176
Electroretinogram abnormal 5 | 95
Hyperinsulinism 5 | 133
Hypogonadism 5 | 173
Keratoconus 5 | 113
Lens Opacities 5 | 231
Male infertility 5 | 206
Nasal bridge wide 5 | 236
Night blindness, progressive 5 | 51
Nystagmus 5 | 317
Ophthalmoplegia 5 | 106
Optic Atrophy 5 | 242
Photodysphoria 5 | 121
Photophobia 5 | 121
Polycystic ovary syndrome 5 | 360
Retinal pigment epithelial abnormality 5 | 111
Retinitis Pigmentosa 5 | 226
Sensorineural Hearing Loss (disorder) 5 | 284
acute myeloid leukemia 5 | 783
interstitial lung disease 5 | 298
nasopharyngeal carcinoma 5 | 1,058
spina bifida 5 | 1,074
tuberculosis 5 | 2,010
Acquired metabolic disease 4 | 336
Alzheimer's disease 4 | 658
Amyotrophic lateral sclerosis 4 | 451
adrenocortical carcinoma 4 | 1,428
atypical teratoid/rhabdoid tumor 4 | 357
ductal carcinoma in situ 4 | 1,745
juvenile dermatomyositis 4 | 1,187
pancreatic carcinoma 4 | 562
pediatric high grade glioma 4 | 1,064
tuberculosis and treatment for 6 months 4 | 409

Tissue

Endocrine System 106 | 18,159
Female tissues 102 | 17,400
Respiratory system 102 | 16,393
Urinary Tract 102 | 16,678
Blood and immune system 101 | 16,909
Digestive Tract 101 | 17,369
Liver and Pancreas 101 | 16,750
Male tissues 101 | 17,142
Nervous System 100 | 16,725
Skin and soft tissues 100 | 17,230
Cardiovascular System 98 | 15,192

Target Family

Non-IDG 105 | 12,091
Enzyme 2 | 4,145

PANTHER Protein Class (3)

mRNA splicing factor 107 | 107
non-receptor serine/threonine ... 162 | 162
translation initiation factor 58 | 58
acetylcholine receptor 47 | 47
non-receptor tyrosine protein ... 37 | 37
voltage-gated calcium channel 23 | 23
mRNA polyadenylation factor 17 | 17
serine/threonine protein kinas... 15 | 15
voltage-gated potassium channe... 15 | 15
voltage-gated sodium channel 9 | 9
translation elongation factor 8 | 8
translation release factor 6 | 6
ionotropic glutamate receptor 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pre-mRNA-splicing factor 18 PRPF18 Tbio Non-IDG -1.36183 19.8 84
U6 snRNA-associated Sm-like protein LSm8 LSM8 Tdark Non-IDG -0.82004 6.23 34
Probable RNA-binding protein 19 RBM19 Tbio Non-IDG -0.42051 3.55 37
RNA-binding protein 14 RBM14 Tbio Non-IDG -2.10043 124.7 168
Pre-mRNA-splicing factor SYF1 XAB2 Tbio Non-IDG -1.02890 12.5 247
Insulin-like growth factor 2 mRNA-binding protein 1 IGF2BP1 Tbio Non-IDG -1.85997 76.0 207
RNA-binding protein EWS EWSR1 Tbio Non-IDG -3.04399 1141.6 411
SURP and G-patch domain-containing protein 2 SUGP2 Tbio Non-IDG 0.12 0.80 118
Small nuclear ribonucleoprotein Sm D3 SNRPD3 Tbio Non-IDG -1.64561 38.0 165
Crooked neck-like protein 1 CRNKL1 Tbio Non-IDG -0.94007 9.12 48