Development Level

Tbio 53 | 11,445
Tclin 11 | 613
Tchem 6 | 1,598
Tdark 4 | 6,588

Collection

Ion Channel: IDG Consortium (T... 14 | 99

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal embryo size 3 | 220
decreased circulating glucose ... 3 | 126
embryonic lethality prior to t... 3 | 278
increased startle reflex 3 | 112
corneal opacity 2 | 32
decreased prepulse inhibition 2 | 82
hemorrhage 2 | 23
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
prenatal lethality 2 | 28
preweaning lethality, incomple... 2 | 499
prolonged PR interval 2 | 15
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal placenta vasculature 1 | 2
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal sensory capabilities-... 1 | 8
abnormal startle reflex 1 | 15
cataract 1 | 92
corneal vascularization 1 | 6
cyanosis 1 | 7
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased cardiac muscle contr... 1 | 11
decreased circulating alkaline... 1 | 46
decreased circulating free fat... 1 | 31
decreased coping response 1 | 8
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased total body fat amoun... 1 | 207
dilated heart left ventricle 1 | 11
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
narrow eye opening 1 | 12
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
respiratory system phenotype 1 | 2
syndactyly 1 | 23
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 66 | 11,493
glioblastoma 43 | 5,792
ovarian cancer 40 | 8,520
osteosarcoma 39 | 7,950
atypical teratoid / rhabdoid tumor 38 | 5,112
psoriasis 36 | 6,694
medulloblastoma, large-cell 34 | 6,241
ependymoma 31 | 4,679
Kidney cancer 29 | 2,613
lung cancer 28 | 4,740
Astrocytoma, Pilocytic 27 | 3,081
lung carcinoma 27 | 2,843
primitive neuroectodermal tumor 27 | 3,035
adult high grade glioma 25 | 3,801
pancreatic cancer 25 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
non-small cell lung cancer 23 | 2,890
Autosomal recessive predisposition 22 | 1,442
lung adenocarcinoma 22 | 2,716
Breast cancer 21 | 3,578
malignant mesothelioma 21 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
oligodendroglioma 20 | 2,850
Cancer 19 | 2,499
invasive ductal carcinoma 19 | 2,951
group 3 medulloblastoma 18 | 4,104
colon cancer 17 | 1,478
Cardiomyopathy 16 | 116
Schizophrenia 16 | 1,160
interstitial cystitis 16 | 2,312
pituitary cancer 16 | 1,972
group 4 medulloblastoma 15 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
cystic fibrosis 14 | 1,696
primary pancreatic ductal adenocarcinoma 14 | 1,109
Bipolar Disorder 13 | 666
Pick disease 13 | 1,894
astrocytic glioma 13 | 2,597
ductal carcinoma in situ 13 | 1,745
pediatric high grade glioma 13 | 1,064
subependymal giant cell astrocytoma 12 | 2,287
tuberculosis 12 | 2,010
Dilated cardiomyopathy 10 | 56
Intellectual disability 10 | 1,016
Muscular dystrophy 10 | 75
Rheumatoid arthritis 10 | 1,191
acute quadriplegic myopathy 10 | 1,158
breast carcinoma 10 | 1,638
dermatomyositis 10 | 966
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
ulcerative colitis 10 | 1,819
Arrhythmogenic right ventricular cardiomyopathy 9 | 30
Cardiomyopathy, Dilated 9 | 83
Creatine phosphokinase serum increased 9 | 110
Duchenne muscular dystrophy 9 | 601
Elevated creatine kinase 9 | 110
Epilepsy 9 | 792
Liver cancer 9 | 604
Myopathy 9 | 185
Skin cancer 9 | 469
astrocytoma 9 | 1,146
diabetes mellitus 9 | 1,728
Dull intelligence 8 | 645
Low intelligence 8 | 645
Melanoma 8 | 711
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Muscle biopsy shows dystrophic changes 8 | 39
Muscle hypotonia 8 | 571
Poor school performance 8 | 645
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
cutaneous lupus erythematosus 8 | 1,057
gastric carcinoma 8 | 807
posterior fossa group A ependymoma 8 | 468
Alopecia 7 | 115
Cardiac Arrhythmia 7 | 103
Endometrial cancer 7 | 311
Gliosis 7 | 56
Heart failure 7 | 162
Liver Cirrhosis, Experimental 7 | 769
Neoplasm Invasiveness 7 | 161
Seizures 7 | 596
Sudden Cardiac Death 7 | 29
limb-girdle muscular dystrophy 7 | 37
medulloblastoma 7 | 720
pancreatic carcinoma 7 | 562
Autistic Disorder 6 | 364
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Heart disease 6 | 306
Hypertensive disease 6 | 292
Mental and motor retardation 6 | 608
Osteoporosis 6 | 363
Stomach Neoplasms 6 | 300
Syncope 6 | 22
Type 2 diabetes mellitus 6 | 272
Ventricular arrhythmia 6 | 27
adrenocortical carcinoma 6 | 1,428
juvenile dermatomyositis 6 | 1,187
nasopharyngeal carcinoma 6 | 1,058

Tissue

Endocrine System 73 | 18,159
Nervous System 72 | 16,725
Digestive Tract 71 | 17,369
Male tissues 70 | 17,142
Blood and immune system 69 | 16,909
Skin and soft tissues 69 | 17,230
Female tissues 68 | 17,400
Urinary Tract 68 | 16,678
Respiratory system 67 | 16,393
Liver and Pancreas 66 | 16,750
Cardiovascular System 61 | 15,192

Target Family

Non-IDG 46 | 12,091
Ion Channel 21 | 344
Transcription Factor 4 | 1,400
Transporter 2 | 473
Enzyme 1 | 4,145

WikiPathways Pathway

Arrhythmogenic Right Ventricul... 74 | 74
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor 7 TCF7 Tbio Transcription Factor -1.74770 44.8 325
Laminin subunit alpha-2 LAMA2 Tbio Non-IDG -2.53347 339.4 135
Catenin beta-1 CTNNB1 Tchem Non-IDG -3.99948 9786.0 3058
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 Tclin Ion Channel -1.56679 32.5 210
Integrin beta-1 ITGB1 Tclin Non-IDG -3.15400 1269.8 1956
Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F Tchem Ion Channel -2.30390 203.0 66
Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 Tbio Ion Channel -0.90841 6.64 294
Actin, cytoplasmic 1 ACTB Tbio Non-IDG -3.52930 2830.7 1251
Integrin alpha-1 ITGA1 Tbio Non-IDG -1.97879 88.9 397