Development Level

Tbio 48 | 11,651
Tchem 14 | 1,388
Tclin 4 | 612

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 2 | 298
abnormal skin morphology 2 | 50
enlarged heart 2 | 210
increased circulating glucose ... 2 | 24
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal femur morphology 1 | 14
abnormal retina morphology 1 | 71
abnormal skin condition 1 | 6
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating triglyce... 1 | 42
increased heart left ventricle... 1 | 4
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
short tibia 1 | 97
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 54 | 11,493
ovarian cancer 44 | 8,520
osteosarcoma 35 | 7,950
Cancer 33 | 2,499
glioblastoma 29 | 5,792
lung cancer 27 | 4,740
Breast cancer 26 | 3,578
psoriasis 26 | 6,694
Kidney cancer 24 | 2,613
medulloblastoma, large-cell 24 | 6,241
ependymoma 23 | 4,679
atypical teratoid / rhabdoid tumor 22 | 5,112
invasive ductal carcinoma 20 | 2,951
malignant mesothelioma 19 | 3,232
pancreatic cancer 19 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
non-small cell lung cancer 18 | 2,890
oligodendroglioma 18 | 2,850
lung adenocarcinoma 17 | 2,716
breast carcinoma 16 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
ulcerative colitis 14 | 1,819
Autosomal recessive predisposition 13 | 1,442
astrocytic glioma 13 | 2,597
group 3 medulloblastoma 13 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
juvenile dermatomyositis 13 | 1,187
Astrocytoma, Pilocytic 12 | 3,081
Muscle hypotonia 12 | 571
adult high grade glioma 12 | 3,801
group 4 medulloblastoma 12 | 1,855
interstitial cystitis 12 | 2,312
lung carcinoma 12 | 2,843
primary pancreatic ductal adenocarcinoma 12 | 1,109
primitive neuroectodermal tumor 12 | 3,035
Multiple myeloma 11 | 1,332
Pick disease 11 | 1,894
astrocytoma 11 | 1,146
cystic fibrosis 11 | 1,696
dermatomyositis 11 | 966
Orbital separation excessive 10 | 244
Rheumatoid arthritis 10 | 1,191
subependymal giant cell astrocytoma 10 | 2,287
Byzanthine arch palate 9 | 194
Carcinoma, Squamous Cell 9 | 110
Failure to gain weight 9 | 365
Joint hyperflexibility 9 | 78
Liver cancer 9 | 604
Melanoma 9 | 711
Pediatric failure to thrive 9 | 365
Schizophrenia 9 | 1,160
Short stature 9 | 531
Squamous cell carcinoma 9 | 129
diabetes mellitus 9 | 1,728
pediatric high grade glioma 9 | 1,064
Acquired scoliosis 8 | 281
Blepharoptosis 8 | 231
Carcinoma, Hepatocellular 8 | 228
Curvature of spine 8 | 282
Epilepsy 8 | 792
Hypoplastic mandible condyle 8 | 275
Liver carcinoma 8 | 240
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Myopia 8 | 176
Stomach Neoplasms 8 | 300
Strabismus 8 | 270
ductal carcinoma in situ 8 | 1,745
pituitary cancer 8 | 1,972
tuberculosis 8 | 2,010
Abnormal dermatoglyphic pattern 7 | 24
Anemia 7 | 365
Downward slant of palpebral fissure 7 | 158
Frontal bossing 7 | 157
Intellectual disability 7 | 1,016
Neoplasm Metastasis 7 | 168
Noonan syndrome 7 | 34
Seizures 7 | 596
esophageal adenocarcinoma 7 | 737
gastric carcinoma 7 | 807
progressive supranuclear palsy 7 | 676
Congenital Epicanthus 6 | 177
Delayed bone age 6 | 136
Dull intelligence 6 | 645
Endometrial cancer 6 | 311
Large auricle 6 | 87
Large protruding ears 6 | 87
Macrotia 6 | 87
Neoplasm Invasiveness 6 | 161
Neuroblastoma 6 | 80
Pectus excavatum 6 | 100
Poor school performance 6 | 645
Prostatic Neoplasms 6 | 495
Skin cancer 6 | 469
acute quadriplegic myopathy 6 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
fibroadenoma 6 | 559
medulloblastoma 6 | 720
nasopharyngeal carcinoma 6 | 1,058

Tissue

Blood and immune system 66 | 16,909
Digestive Tract 66 | 17,369
Endocrine System 66 | 18,159
Female tissues 66 | 17,400
Male tissues 66 | 17,142
Nervous System 66 | 16,725
Skin and soft tissues 66 | 17,230
Urinary Tract 66 | 16,678
Liver and Pancreas 65 | 16,750
Respiratory system 65 | 16,393
Cardiovascular System 63 | 15,192

Target Family

Non-IDG 39 | 12,091
Enzyme 21 | 4,145
Kinase 5 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Signaling by MET 66 | 66
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Tensin-3 TNS3 Tbio Non-IDG -2.06381 115.1 78
Ran-binding protein 10 RANBP10 Tbio Non-IDG -0.89234 8.16 51
Ras-related protein Rab-4A RAB4A Tbio Enzyme -2.20077 148.7 256
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
Dedicator of cytokinesis protein 7 DOCK7 Tbio Non-IDG -1.21382 17.1 63
Laminin subunit alpha-3 LAMA3 Tbio Non-IDG -2.53686 344.3 110
Mucin-20 MUC20 Tbio Non-IDG -1.05904 12.8 132