Development Level

Tbio 52 | 11,651
Tchem 8 | 1,388
Tclin 2 | 612
Tdark 2 | 6,593

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 7 | 278
abnormal embryo size 3 | 220
abnormal embryo turning 3 | 31
abnormal blood vessel morpholo... 2 | 5
abnormal eye morphology 2 | 68
abnormal pharyngeal arch morph... 2 | 8
decreased circulating glucose ... 2 | 126
embryonic growth retardation 2 | 106
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo development 1 | 7
abnormal eye size 1 | 7
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal placement of pupils 1 | 6
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
female infertility 1 | 60
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 44 | 8,520
Carcinoma 41 | 11,493
osteosarcoma 36 | 7,950
group 3 medulloblastoma 31 | 4,104
lung cancer 29 | 4,740
Breast cancer 27 | 3,578
malignant mesothelioma 27 | 3,232
Cancer 25 | 2,499
medulloblastoma, large-cell 24 | 6,241
psoriasis 24 | 6,694
glioblastoma 22 | 5,792
non-small cell lung cancer 21 | 2,890
primitive neuroectodermal tumor 20 | 3,035
atypical teratoid / rhabdoid tumor 19 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
Fanconi anemia 16 | 56
Short stature 15 | 531
adult high grade glioma 15 | 3,801
invasive ductal carcinoma 15 | 2,951
Autosomal recessive predisposition 14 | 1,442
Bloom syndrome 14 | 29
colon cancer 14 | 1,478
ductal carcinoma in situ 14 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
nasopharyngeal carcinoma 14 | 1,058
ependymoma 13 | 4,679
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
Small head 12 | 374
Dull intelligence 11 | 645
Hereditary Breast and Ovarian Cancer Syndrome 11 | 14
Intellectual disability 11 | 1,016
Kidney cancer 11 | 2,613
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
lung adenocarcinoma 11 | 2,716
Ataxia telangiectasia 10 | 34
adrenocortical carcinoma 10 | 1,428
non primary Sjogren syndrome sicca 10 | 891
Anemia 9 | 365
Nijmegen breakage syndrome 8 | 24
Seckel syndrome 8 | 34
astrocytic glioma 8 | 2,597
oligodendroglioma 8 | 2,850
Chromosome Breakage 7 | 36
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Hypoplastic mandible condyle 7 | 275
Malignant neoplasm of breast 7 | 15
Mandibular hypoplasia 7 | 275
Mental and motor retardation 7 | 608
Micrognathism 7 | 275
Xeroderma pigmentosum 7 | 43
breast carcinoma 7 | 1,638
diabetes mellitus 7 | 1,728
Acquired scoliosis 6 | 281
Convex nasal ridge 6 | 37
Curvature of spine 6 | 282
Decreased platelet count 6 | 111
Increased chromosomal breakage 6 | 27
Thrombocytopenia 6 | 197
Waldenstrons macroglobulinemia 6 | 765
acute myeloid leukemia 6 | 783
lung carcinoma 6 | 2,843
pituitary cancer 6 | 1,972
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3 5 | 9
Esophageal atresia with or without tracheoesophageal fistula 5 | 21
Fetal Growth Retardation 5 | 189
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
Leukopenia 5 | 72
Lynch syndrome 5 | 35
Narrow face 5 | 54
Ovarian Neoplasms 5 | 102
Prostate cancer 5 | 175
Thin face 5 | 54
Werner syndrome 5 | 29
Xeroderma pigmentosum group F 5 | 22
esophageal atresia/tracheoesophageal fistula 5 | 22
hypopigmented skin patch 5 | 59
ovarian neoplasm 5 | 99
pancreatic cancer 5 | 2,398
Astrocytoma, Pilocytic 4 | 3,081
Bilateral fifth finger clinodactyly 4 | 110
Cockayne syndrome 4 | 60
Colorectal Neoplasms 4 | 243
Curvature of little finger 4 | 110
Hyperplasia of nose 4 | 23
Hypertrophy of nose 4 | 23
Large nose 4 | 23
Microcephaly 4 | 166
Prostatic Neoplasms 4 | 495
Schizophrenia 4 | 1,160
Short palpebral fissure 4 | 38
astrocytoma 4 | 1,146
dermatomyositis 4 | 966
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
tuberculosis and treatment for 6 months 4 | 409

Tissue

Blood and immune system 64 | 16,909
Digestive Tract 64 | 17,369
Endocrine System 64 | 18,159
Female tissues 64 | 17,400
Male tissues 64 | 17,142
Nervous System 64 | 16,725
Respiratory system 64 | 16,393
Skin and soft tissues 64 | 17,230
Urinary Tract 64 | 16,678
Cardiovascular System 63 | 15,192
Liver and Pancreas 63 | 16,750

Target Family

Non-IDG 39 | 12,091
Enzyme 22 | 4,145
Kinase 2 | 634
Epigenetic 1 | 242

Reactome Pathway

HDR through Homologous Recombi... 64 | 64
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
DNA repair protein XRCC3 XRCC3 Tbio Non-IDG -2.50791 314.0 414
DNA topoisomerase 3-alpha TOP3A Tbio Enzyme -2.77897 560.7 45
DNA topoisomerase 2-binding protein 1 TOPBP1 Tbio Enzyme -2.04312 118.0 230
DNA repair-scaffolding protein SPIDR Tbio Non-IDG -0.75333 5.57 24
DNA polymerase kappa POLK Tbio Enzyme -2.42142 256.3 224
Checkpoint protein HUS1 HUS1 Tbio Non-IDG -1.87625 67.8 180
Nibrin NBN Tbio Non-IDG -1.95649 97.2 1094
Cell cycle checkpoint protein RAD1 RAD1 Tchem Non-IDG -1.91713 78.3 245