Development Level

Tbio 1,028 | 10,625
Tdark 465 | 7,003
Tchem 217 | 1,890
Tclin 45 | 602

Collection

Eligible Kinase Proteins 9 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 106 | 633
embryonic lethality prior to o... 35 | 148
embryonic lethality prior to t... 35 | 187
preweaning lethality, incomple... 27 | 260
abnormal behavior 20 | 226
abnormal embryo size 18 | 112
decreased lean body mass 13 | 195
abnormal lens morphology 12 | 73
increased grip strength 12 | 83
decreased body weight 11 | 174
enlarged heart 11 | 111
decreased body length 10 | 108
increased mean corpuscular hem... 10 | 93
increased or absent threshold ... 10 | 128
abnormal bone structure 9 | 131
decreased grip strength 9 | 123
increased circulating HDL chol... 9 | 63
increased circulating alkaline... 9 | 119
abnormal retina morphology 8 | 100
decreased circulating glucose ... 8 | 121
decreased total body fat amoun... 8 | 186
prenatal lethality prior to he... 8 | 64
cataract 7 | 26
decreased bone mineral content 7 | 157
decreased circulating HDL chol... 7 | 77
decreased mean corpuscular vol... 7 | 50
increased circulating triglyce... 7 | 24
increased sacral vertebrae num... 7 | 62
abnormal tooth morphology 6 | 24
decreased bone mineral density 6 | 126
decreased caudal vertebrae num... 6 | 49
decreased circulating LDL chol... 6 | 37
decreased circulating choleste... 6 | 85
decreased fasted circulating g... 6 | 49
decreased hemoglobin content 6 | 53
decreased leukocyte cell numbe... 6 | 54
hypoactivity 6 | 89
increased circulating choleste... 6 | 53
increased circulating sodium l... 6 | 71
increased exploration in new e... 6 | 56
male infertility 6 | 62
abnormal coat/hair pigmentatio... 5 | 54
abnormal snout morphology 5 | 18
decreased circulating serum al... 5 | 79
decreased eosinophil cell numb... 5 | 41
decreased lumbar vertebrae num... 5 | 62
decreased neutrophil cell numb... 5 | 37
decreased rib number 5 | 59
hyperactivity 5 | 108
increased circulating creatini... 5 | 29
increased fasted circulating g... 5 | 68
increased mean corpuscular vol... 5 | 91
increased mean platelet volume 5 | 19
abnormal bone mineralization 4 | 55
abnormal cranium morphology 4 | 32
abnormal heart morphology 4 | 51
abnormal joint morphology 4 | 14
abnormal neural tube closure 4 | 37
corneal opacity 4 | 25
decreased Ly6C low monocyte nu... 4 | 23
decreased NK cell number 4 | 16
decreased circulating amylase ... 4 | 24
decreased circulating calcium ... 4 | 33
decreased circulating sodium l... 4 | 18
decreased startle reflex 4 | 48
embryonic growth retardation 4 | 28
increased bone mineral content 4 | 92
increased circulating LDL chol... 4 | 15
increased circulating chloride... 4 | 43
increased circulating free fat... 4 | 17
pallor 4 | 13
short tibia 4 | 82
abnormal embryo turning 3 | 15
abnormal epididymis morphology 3 | 31
abnormal retinal pigmentation 3 | 61
abnormal skin coloration 3 | 18
abnormal spleen morphology 3 | 36
decreased CD4-positive, CD25-p... 3 | 24
decreased Ly6C high monocyte n... 3 | 18
decreased T cell number 3 | 31
decreased circulating triglyce... 3 | 83
decreased effector memory CD8-... 3 | 24
decreased heart weight 3 | 44
decreased total retina thickne... 3 | 20
enlarged lymph nodes 3 | 27
enlarged spleen 3 | 26
impaired glucose tolerance 3 | 52
increased body length 3 | 20
increased circulating glycerol... 3 | 11
increased circulating iron lev... 3 | 25
increased circulating serum al... 3 | 25
increased heart rate 3 | 17
increased heart weight 3 | 37
increased hemoglobin content 3 | 45
increased lean body mass 3 | 107
increased total body fat amoun... 3 | 57
shortened RR interval 3 | 19
small testis 3 | 37
thrombocytopenia 3 | 46
thrombocytosis 3 | 23

Disease

ovarian cancer 947 | 8,484
osteosarcoma 805 | 7,933
lung cancer 571 | 4,466
medulloblastoma, large-cell 551 | 6,234
psoriasis 551 | 6,685
glioblastoma 466 | 5,572
atypical teratoid / rhabdoid tumor 336 | 4,369
Cancer 319 | 2,346
group 3 medulloblastoma 319 | 2,254
malignant mesothelioma 298 | 3,162
Breast cancer 296 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 281 | 3,289
primitive neuroectodermal tumor 280 | 3,031
Multiple myeloma 274 | 1,327
oligodendroglioma 249 | 2,849
ependymoma 229 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 227 | 2,988
pediatric high grade glioma 214 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 212 | 2,956
invasive ductal carcinoma 208 | 2,950
non-small cell lung cancer 206 | 2,798
group 4 medulloblastoma 193 | 1,875
Carcinoma 185 | 2,147
diabetes mellitus 184 | 1,663
astrocytic glioma 179 | 2,241
lung adenocarcinoma 175 | 2,713
acute quadriplegic myopathy 174 | 1,157
Pick disease 172 | 1,893
pancreatic cancer 168 | 2,300
astrocytoma 164 | 1,493
Waldenstrons macroglobulinemia 161 | 765
pancreatic ductal adenocarcinoma liver metastasis 158 | 1,795
pilocytic astrocytoma 147 | 3,086
colon cancer 146 | 1,475
subependymal giant cell astrocytoma 145 | 2,287
sonic hedgehog group medulloblastoma 143 | 1,482
dermatomyositis 133 | 933
adult high grade glioma 128 | 2,148
pituitary cancer 124 | 1,972
lung carcinoma 123 | 2,844
juvenile dermatomyositis 122 | 1,189
adrenocortical carcinoma 119 | 1,427
tuberculosis 114 | 1,557
breast carcinoma 112 | 1,614
ulcerative colitis 112 | 2,087
medulloblastoma 108 | 1,524
acute myeloid leukemia 106 | 780
atypical teratoid/rhabdoid tumor 106 | 1,095
ductal carcinoma in situ 106 | 1,745
Rheumatoid Arthritis 103 | 1,160
interstitial cystitis 98 | 2,299
non primary Sjogren syndrome sicca 98 | 840
primary pancreatic ductal adenocarcinoma 89 | 1,271
spina bifida 88 | 1,064
posterior fossa group A ependymoma 85 | 1,511
cystic fibrosis 82 | 1,665
Mammary Neoplasms 81 | 410
tuberculosis and treatment for 6 months 78 | 686
nasopharyngeal carcinoma 73 | 1,056
Intellectual disability 71 | 573
posterior fossa group B ependymoma 71 | 1,530
hepatocellular carcinoma 68 | 532
progressive supranuclear palsy 68 | 674
cutaneous lupus erythematosus 66 | 1,056
Stomach Neoplasms 65 | 282
Prostatic Neoplasms 64 | 471
gastric cancer 64 | 430
pancreatic carcinoma 61 | 567
Alzheimer's disease 58 | 644
Endometriosis 58 | 535
active Crohn's disease 56 | 918
Amyotrophic Lateral Sclerosis 52 | 431
Obesity 50 | 616
gastric carcinoma 50 | 832
Atopic dermatitis 49 | 944
aldosterone-producing adenoma 47 | 664
Neurodegenerative disease 46 | 383
esophageal adenocarcinoma 43 | 737
primary Sjogren syndrome 41 | 789
HIV Infections 39 | 100
Polycystic Ovary Syndrome 39 | 332
IGA Glomerulonephritis 38 | 454
inflammatory breast cancer 38 | 404
tuberculosis and treatment for 3 months 37 | 327
Peripheral Neuropathy 36 | 303
Schizophrenia 36 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 36 | 499
Liver carcinoma 35 | 217
Lung Neoplasms 35 | 171
Disease Progression 34 | 125
Kidney disease 34 | 396
Duchenne muscular dystrophy 33 | 602
glioblastoma multiforme 32 | 347
mucosa-associated lymphoid tissue lymphoma 32 | 480
Heart disease 30 | 279
Mammary Neoplasms, Experimental 29 | 150
Melanoma 29 | 261
Parkinson's disease 29 | 364
Vascular disease 29 | 281
sarcoidosis 29 | 358

Tissue

Nervous System 1,738 | 18,561
Female tissues 1,736 | 18,647
Blood and immune system 1,735 | 17,995
Digestive Tract 1,734 | 18,473
Male tissues 1,734 | 17,969
Endocrine System 1,731 | 18,512
Liver and Pancreas 1,731 | 18,136
Urinary Tract 1,730 | 18,444
Cardiovascular System 1,728 | 17,958
Respiratory system 1,717 | 17,484
Skin and soft tissues 1,702 | 18,115

Target Family

Non-IDG 809 | 11,971
Enzyme 399 | 4,146
Transcription Factor 380 | 1,400
Kinase 60 | 634
Epigenetic 52 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 6 | 38
GPCR 1 | 406
Transporter 1 | 473

Reactome Pathway

Gene Expression 1,755 | 1,755
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability