Development Level

Tbio 54 | 10,625
Tchem 22 | 1,890
Tclin 5 | 602
Tdark 3 | 7,003

IMPC Phenotype

preweaning lethality, complete... 11 | 633
embryonic lethality prior to t... 5 | 187
embryonic lethality prior to o... 4 | 148
abnormal embryo size 3 | 112
embryonic growth retardation 3 | 28
anophthalmia 2 | 20
increased mean corpuscular vol... 2 | 91
abnormal bone structure 1 | 131
abnormal craniofacial morpholo... 1 | 12
abnormal forebrain morphology 1 | 4
abnormal head shape 1 | 4
abnormal hindbrain morphology 1 | 2
abnormal kidney morphology 1 | 30
abnormal midbrain morphology 1 | 2
abnormal neural tube closure 1 | 37
abnormal placenta morphology 1 | 4
abnormal placenta size 1 | 10
abnormal skin coloration 1 | 18
decreased basophil cell number 1 | 11
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating glucose ... 1 | 121
decreased eosinophil cell numb... 1 | 41
decreased lean body mass 1 | 195
edema 1 | 11
enlarged lymph nodes 1 | 27
improved glucose tolerance 1 | 56
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating glucose ... 1 | 16
increased circulating sodium l... 1 | 71
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
microphthalmia 1 | 15
pallor 1 | 13
prenatal lethality 1 | 16
urinary bladder obstruction 1 | 2

Disease

ovarian cancer 61 | 8,491
psoriasis 43 | 6,685
lung cancer 41 | 4,473
glioblastoma 38 | 5,572
osteosarcoma 37 | 7,933
medulloblastoma, large-cell 29 | 6,234
Multiple myeloma 28 | 1,327
Cancer 26 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
Breast cancer 21 | 3,098
malignant mesothelioma 21 | 3,163
non-small cell lung cancer 21 | 2,798
invasive ductal carcinoma 20 | 2,950
pediatric high grade glioma 20 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
adrenocortical carcinoma 17 | 1,427
atypical teratoid / rhabdoid tumor 17 | 4,369
lung adenocarcinoma 17 | 2,714
primitive neuroectodermal tumor 16 | 3,031
HIV Infections 14 | 99
colon cancer 14 | 1,475
pancreatic cancer 14 | 2,300
Endometriosis 13 | 535
posterior fossa group A ependymoma 13 | 1,511
Atopic dermatitis 12 | 944
Waldenstrons macroglobulinemia 12 | 764
breast carcinoma 12 | 1,614
group 3 medulloblastoma 12 | 2,254
dermatomyositis 11 | 966
ductal carcinoma in situ 11 | 1,745
IGA Glomerulonephritis 10 | 454
oligodendroglioma 10 | 2,849
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
primary Sjogren syndrome 10 | 788
astrocytoma 9 | 1,493
nasopharyngeal carcinoma 9 | 1,056
sonic hedgehog group medulloblastoma 9 | 1,482
astrocytic glioma 8 | 2,241
esophageal adenocarcinoma 8 | 737
medulloblastoma 8 | 1,524
non primary Sjogren syndrome sicca 8 | 840
pilocytic astrocytoma 8 | 3,086
ulcerative colitis 8 | 2,087
Pick disease 7 | 1,893
atypical teratoid/rhabdoid tumor 7 | 1,095
diabetes mellitus 7 | 1,663
interstitial cystitis 7 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
active Crohn's disease 6 | 918
ependymoma 6 | 2,514
Mantle cell lymphoma 5 | 20
acute quadriplegic myopathy 5 | 1,157
cutaneous lupus erythematosus 5 | 1,056
lung carcinoma 5 | 2,844
primary pancreatic ductal adenocarcinoma 5 | 1,271
subependymal giant cell astrocytoma 5 | 2,287
Peripheral Neuropathy 4 | 303
Squamous cell carcinoma of esophagus 4 | 82
acute myeloid leukemia 4 | 785
juvenile dermatomyositis 4 | 1,189
pituitary cancer 4 | 1,972
tuberculosis 4 | 1,563
Osteoporosis 3 | 259
inflammatory breast cancer 3 | 404
posterior fossa group B ependymoma 3 | 1,530
progressive supranuclear palsy 3 | 674
Acquired metabolic disease 2 | 267
Alzheimer's disease 2 | 644
Carcinoma of colon 2 | 32
Colorectal Neoplasms 2 | 217
Diffuse large B-cell lymphoma 2 | 42
Duchenne muscular dystrophy 2 | 602
Liver carcinoma 2 | 217
MOSAIC VARIEGATED ANEUPLOIDY SYNDROME 2 | 4
Mammary Neoplasms 2 | 410
Mammary Neoplasms, Experimental 2 | 149
Melanoma 2 | 261
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Parkinson's disease 2 | 364
Pick's disease 2 | 14
Polycystic Ovary Syndrome 2 | 334
Rheumatoid Arthritis 2 | 1,170
Stevens-Johnson syndrome 2 | 91
adult high grade glioma 2 | 2,148
chronic kidney disease 2 | 90
cystic fibrosis 2 | 1,670
gastric cancer 2 | 436
group 4 medulloblastoma 2 | 1,875
hepatocellular carcinoma 2 | 550
mosaic variegated aneuploidy syndrome 1 2 | 4
sarcoidosis 2 | 368
tuberculosis and treatment for 6 months 2 | 686
Degenerative polyarthritis 1 | 93
Microcephaly 1 | 149
Retinitis pigmentosa 1 | 156
Sjogren's syndrome 1 | 23
cystic fibrosis and chronic rhinosinusitis 1 | 213
limb girdle muscular dystrophy 2B 1 | 74
systemic lupus erythematosus 1 | 172

Tissue

Blood and immune system 84 | 17,994
Digestive Tract 84 | 18,472
Endocrine System 84 | 18,511
Female tissues 84 | 18,646
Liver and Pancreas 84 | 18,135
Male tissues 84 | 17,968
Nervous System 84 | 18,560
Urinary Tract 84 | 18,443
Cardiovascular System 83 | 17,957
Respiratory system 83 | 17,483
Skin and soft tissues 83 | 18,114

Target Family

Enzyme 51 | 4,146
Non-IDG 26 | 11,969
Kinase 7 | 634

Reactome Pathway

APC/C-mediated degradation of ... 84 | 84
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Polyubiquitin-B UBB Tbio Non-IDG -1.96206 92.3 370
Polyubiquitin-C UBC Tbio Non-IDG -2.87696 56.7 130
F-box/WD repeat-containing protein 1A BTRC Tbio Non-IDG -2.36675 208.2 164
Aurora kinase B AURKB Tchem Kinase -2.89489 769.4 572
26S proteasome non-ATPase regulatory subunit 4 PSMD4 Tbio Enzyme -2.13544 133.8 271
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.86105 71.4 158
Cullin-1 CUL1 Tbio Non-IDG -2.33531 167.2 343
Cell division cycle protein 23 homolog CDC23 Tbio Non-IDG -1.49289 30.4 170
Anaphase-promoting complex subunit 2 ANAPC2 Tbio Enzyme -0.34336 1.78 117
Anaphase-promoting complex subunit 4 ANAPC4 Tbio Enzyme 0.78 0.13 121