Development Level

Tbio 255 | 11,445
Tdark 56 | 6,588
Tchem 27 | 1,598
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, complete... 34 | 979
embryonic lethality prior to o... 13 | 239
preweaning lethality, incomple... 13 | 499
abnormal behavior 11 | 298
abnormal embryo size 11 | 220
decreased body weight 10 | 161
embryonic lethality prior to t... 10 | 278
abnormal bone structure 7 | 187
male infertility 7 | 123
embryonic growth retardation 6 | 106
decreased bone mineral density 5 | 126
female infertility 5 | 60
abnormal heart morphology 4 | 162
abnormal neural tube closure 4 | 46
decreased hemoglobin content 4 | 68
decreased leukocyte cell numbe... 4 | 73
decreased mean corpuscular hem... 4 | 31
decreased vertical activity 4 | 208
enlarged heart 4 | 210
hyperactivity 4 | 148
increased circulating alkaline... 4 | 122
increased lean body mass 4 | 172
increased mean corpuscular vol... 4 | 92
increased total body fat amoun... 4 | 134
thrombocytopenia 4 | 56
abnormal embryo turning 3 | 31
decreased body length 3 | 101
decreased bone mineral content 3 | 151
decreased caudal vertebrae num... 3 | 53
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
decreased lean body mass 3 | 135
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
edema 3 | 59
increased circulating HDL chol... 3 | 80
abnormal bone mineralization 2 | 38
abnormal forebrain development 2 | 20
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
abnormal pericardium morpholog... 2 | 26
abnormal placenta size 2 | 20
abnormal rib morphology 2 | 10
abnormal spleen morphology 2 | 55
abnormal vertebrae morphology 2 | 18
abnormal vertebral arch morpho... 2 | 9
cataract 2 | 92
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased red blood cell distr... 2 | 41
decreased total body fat amoun... 2 | 207
hypoactivity 2 | 132
increased bone mineral density 2 | 72
increased circulating choleste... 2 | 66
increased circulating creatine... 2 | 5
increased circulating sodium l... 2 | 71
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 36
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
increased thermal nociceptive ... 2 | 9
pale yolk sac 2 | 25
pallor 2 | 34
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
shortened RR interval 2 | 17
small kidney 2 | 16
small testis 2 | 58
thrombocytosis 2 | 27
tremors 2 | 39
trunk curl 2 | 16
vertebral fusion 2 | 23
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal heart left ventricle ... 1 | 16
abnormal neural tube morpholog... 1 | 12
abnormal retina morphology 1 | 71
abnormal vocalization 1 | 21
absent spleen 1 | 3
decreased circulating bilirubi... 1 | 19
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased grip strength 1 | 116
decreased neutrophil cell numb... 1 | 42
increased anti-nuclear antigen... 1 | 19
increased blood uric acid leve... 1 | 5
increased circulating aspartat... 1 | 15
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
prenatal lethality 1 | 28

Disease

Carcinoma 206 | 11,493
ovarian cancer 180 | 8,520
osteosarcoma 165 | 7,950
psoriasis 125 | 6,694
medulloblastoma, large-cell 121 | 6,241
lung cancer 113 | 4,740
glioblastoma 108 | 5,792
group 3 medulloblastoma 105 | 4,104
Breast cancer 97 | 3,578
atypical teratoid / rhabdoid tumor 94 | 5,112
Cancer 80 | 2,499
malignant mesothelioma 80 | 3,232
primitive neuroectodermal tumor 68 | 3,035
non-small cell lung cancer 65 | 2,890
lung adenocarcinoma 62 | 2,716
ependymoma 60 | 4,679
adult high grade glioma 54 | 3,801
invasive ductal carcinoma 53 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 52 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 51 | 3,291
breast carcinoma 40 | 1,638
oligodendroglioma 39 | 2,850
colon cancer 37 | 1,478
Kidney cancer 36 | 2,613
pancreatic cancer 36 | 2,398
pituitary cancer 36 | 1,972
diabetes mellitus 34 | 1,728
group 4 medulloblastoma 34 | 1,855
subependymal giant cell astrocytoma 34 | 2,287
astrocytic glioma 32 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,955
Astrocytoma, Pilocytic 31 | 3,081
adrenocortical carcinoma 31 | 1,428
ductal carcinoma in situ 31 | 1,745
Autosomal recessive predisposition 30 | 1,442
tuberculosis 30 | 2,010
Multiple myeloma 29 | 1,332
acute quadriplegic myopathy 28 | 1,158
Pick disease 27 | 1,894
Intellectual disability 26 | 1,016
Rheumatoid arthritis 26 | 1,191
Schizophrenia 26 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,962
astrocytoma 24 | 1,146
hepatocellular carcinoma 23 | 547
juvenile dermatomyositis 23 | 1,187
lung carcinoma 23 | 2,843
non primary Sjogren syndrome sicca 22 | 891
Waldenstrons macroglobulinemia 21 | 765
dermatomyositis 21 | 966
spina bifida 21 | 1,074
ulcerative colitis 21 | 1,819
Short stature 19 | 531
Small head 19 | 374
cystic fibrosis 19 | 1,696
gastric cancer 19 | 459
nasopharyngeal carcinoma 19 | 1,058
Endometriosis 18 | 540
acute myeloid leukemia 18 | 783
pancreatic carcinoma 18 | 562
progressive supranuclear palsy 18 | 676
Bipolar Disorder 17 | 666
Xeroderma pigmentosum 17 | 43
interstitial cystitis 17 | 2,312
medulloblastoma 17 | 720
pediatric high grade glioma 17 | 1,064
tuberculosis and treatment for 6 months 17 | 409
Attention deficit hyperactivity disorder 16 | 278
Cognitive delay 16 | 608
Global developmental delay 16 | 608
Mental and motor retardation 16 | 608
Alzheimer's disease 15 | 658
Muscle hypotonia 15 | 571
cutaneous lupus erythematosus 15 | 1,057
Atopic dermatitis 14 | 952
Dull intelligence 14 | 645
Low intelligence 14 | 645
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Poor school performance 14 | 645
primary pancreatic ductal adenocarcinoma 14 | 1,109
Cockayne syndrome 13 | 60
Depressive disorder 13 | 409
Failure to gain weight 13 | 365
Pediatric failure to thrive 13 | 365
Prostatic Neoplasms 13 | 495
gastric carcinoma 13 | 807
non-small cell lung carcinoma 13 | 317
Acquired metabolic disease 12 | 336
Epilepsy 12 | 792
Fetal Growth Retardation 12 | 189
Infant, Small for Gestational Age 12 | 176
Intrauterine retardation 12 | 176
Lynch syndrome 12 | 35
Male infertility 12 | 206
Strabismus 12 | 270
aldosterone-producing adenoma 12 | 665
sonic hedgehog group medulloblastoma 12 | 467
Obesity 11 | 678
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510

Tissue

Endocrine System 325 | 18,159
Female tissues 315 | 17,400
Digestive Tract 314 | 17,369
Skin and soft tissues 314 | 17,230
Nervous System 313 | 16,725
Blood and immune system 312 | 16,909
Male tissues 312 | 17,142
Liver and Pancreas 307 | 16,750
Respiratory system 307 | 16,393
Urinary Tract 306 | 16,678
Cardiovascular System 297 | 15,192

Target Family

Non-IDG 191 | 12,091
Enzyme 69 | 4,145
Transcription Factor 51 | 1,400
Epigenetic 27 | 242
TF/Epigenetic 4 | 38

PANTHER Protein Class (1)

DNA binding protein 342 | 342
protease 516 | 516
RNA binding protein 483 | 483
kinase 362 | 362
protease inhibitor 256 | 256
G-protein coupled receptor 221 | 221
actin family cytoskeletal prot... 221 | 221
KRAB box transcription factor 193 | 193
microtubule family cytoskeleta... 189 | 189
ion channel 186 | 186
G-protein modulator 179 | 179
dehydrogenase 173 | 173
phosphatase 163 | 163
G-protein 131 | 131
cation transporter 127 | 127
glycosyltransferase 121 | 121
nuclease 110 | 110
growth factor 104 | 104
cytokine 101 | 101
kinase modulator 99 | 99
ubiquitin-protein ligase 99 | 99
helix-turn-helix transcription... 98 | 98
transcription cofactor 96 | 96
serine protease 79 | 79
immunoglobulin 76 | 76
helicase 75 | 75
membrane trafficking regulator... 75 | 75
zinc finger transcription fact... 74 | 74
immunoglobulin receptor superf... 71 | 71
winged helix/forkhead transcri... 70 | 70
cysteine protease 69 | 69
acetyltransferase 68 | 68
oxygenase 68 | 68
basic helix-loop-helix transcr... 60 | 60
acyltransferase 59 | 59
extracellular matrix glycoprot... 53 | 53
methyltransferase 53 | 53
peptide hormone 52 | 52
phosphatase modulator 51 | 51
intracellular calcium-sensing ... 47 | 47
membrane-bound signaling molec... 47 | 47
reductase 42 | 42
C4 zinc finger nuclear recepto... 41 | 41
vesicle coat protein 40 | 40
oxidase 39 | 39
ATP-binding cassette (ABC) tra... 36 | 36
cytokine receptor 36 | 36
tight junction 35 | 35
esterase 32 | 32
extracellular matrix structura... 31 | 31
SNARE protein 30 | 30
lipase 30 | 30
amino acid transporter 28 | 28
basic leucine zipper transcrip... 27 | 27
Rel homology transcription fac... 25 | 25
aminoacyl-tRNA synthetase 24 | 24
peroxidase 24 | 24
dehydratase 23 | 23
deaminase 22 | 22
gap junction 21 | 21
major histocompatibility compl... 21 | 21
carbohydrate transporter 20 | 20
nucleotidyltransferase 20 | 20
transaminase 18 | 18
glycosidase 16 | 16
metalloprotease 16 | 16
homeodomain transcription fact... 15 | 15
intermediate filament 15 | 15
mitochondrial carrier protein 15 | 15
HMG box transcription factor 14 | 14
apolipoprotein 13 | 13
chaperonin 13 | 13
annexin 12 | 12
decarboxylase 12 | 12
Hsp90 family chaperone 9 | 9
phosphorylase 9 | 9
glucosidase 8 | 8
cadherin 7 | 7
cyclase 7 | 7
antibacterial response protein 6 | 6
deacetylase 6 | 6
phosphodiesterase 6 | 6
MADS box transcription factor 5 | 5
galactosidase 5 | 5
hydroxylase 5 | 5
mutase 5 | 5
immunoglobulin superfamily cel... 4 | 4
pyrophosphatase 4 | 4
P53-like transcription factor 3 | 3
Runt transcription factor 3 | 3
TATA-binding transcription fac... 3 | 3
myelin protein 3 | 3
amylase 2 | 2
epimerase/racemase 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability