Development Level

Tbio 334 | 11,178
Tchem 202 | 1,885
Tdark 66 | 6,569
Tclin 18 | 612

Collection

Kinase: IDG Consortium (Target... 59 | 125
Kinase: IDG Consortium (Comple... 22 | 37

IMPC Phenotype

preweaning lethality, complete... 46 | 979
preweaning lethality, incomple... 29 | 499
embryonic lethality prior to t... 18 | 278
embryonic lethality prior to o... 16 | 239
abnormal embryo size 11 | 220
abnormal behavior 9 | 298
enlarged heart 9 | 210
abnormal heart morphology 7 | 162
decreased circulating glucose ... 6 | 126
decreased lean body mass 6 | 135
increased monocyte cell number 6 | 63
increased or absent threshold ... 6 | 101
abnormal bone structure 5 | 187
abnormal kidney morphology 5 | 65
abnormal seminal vesicle morph... 5 | 114
decreased total body fat amoun... 5 | 207
decreased vertical activity 5 | 208
embryonic growth retardation 5 | 106
hypoactivity 5 | 132
increased bone mineral content 5 | 108
increased bone mineral density 5 | 72
increased lean body mass 5 | 172
increased mean corpuscular vol... 5 | 92
increased startle reflex 5 | 112
increased total body fat amoun... 5 | 134
abnormal eye morphology 4 | 68
abnormal neural tube closure 4 | 46
abnormal spleen morphology 4 | 55
decreased bone mineral content 4 | 151
decreased hemoglobin content 4 | 68
decreased lymphocyte cell numb... 4 | 83
decreased prepulse inhibition 4 | 82
decreased startle reflex 4 | 75
enlarged lymph nodes 4 | 37
increased circulating alkaline... 4 | 122
microphthalmia 4 | 26
small superior vagus ganglion 4 | 74
abnormal coat-hair pigmentatio... 3 | 64
abnormal embryo turning 3 | 31
abnormal locomotor behavior 3 | 24
abnormal skin morphology 3 | 50
cataract 3 | 92
decreased body length 3 | 101
decreased body weight 3 | 161
decreased circulating creatini... 3 | 39
decreased circulating serum al... 3 | 82
decreased grip strength 3 | 116
decreased hematocrit 3 | 46
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
edema 3 | 59
enlarged spleen 3 | 41
hydrometra 3 | 53
hyperactivity 3 | 148
improved glucose tolerance 3 | 79
increased body length 3 | 32
increased circulating sodium l... 3 | 71
male infertility 3 | 123
abnormal bone mineralization 2 | 38
abnormal epididymis morphology 2 | 42
abnormal forebrain development 2 | 20
abnormal lens morphology 2 | 81
abnormal midbrain development 2 | 20
abnormal sleep behavior 2 | 70
abnormal tail movements 2 | 12
abnormal tooth morphology 2 | 24
anophthalmia 2 | 33
decreased circulating fructosa... 2 | 30
decreased circulating glycerol... 2 | 16
decreased circulating insulin ... 2 | 76
decreased circulating magnesiu... 2 | 13
decreased erythrocyte cell num... 2 | 62
decreased leukocyte cell numbe... 2 | 73
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
decreased total retina thickne... 2 | 17
enlarged epididymis 2 | 31
increased erythrocyte cell num... 2 | 39
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 96
increased prepulse inhibition 2 | 32
limb grasping 2 | 41
long tibia 2 | 25
persistence of hyaloid vascula... 2 | 33
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
short tibia 2 | 97
small seminal vesicle 2 | 10
small testis 2 | 58
abnormal body wall morphology 1 | 9
abnormal retina morphology 1 | 71
abnormal vertebrae morphology 1 | 18
decreased circulating bilirubi... 1 | 19
decreased pulmonary respirator... 1 | 5
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
vertebral fusion 1 | 23

Disease

Carcinoma 420 | 11,192
ovarian cancer 317 | 8,297
osteosarcoma 298 | 7,766
psoriasis 251 | 6,514
medulloblastoma, large-cell 225 | 6,086
glioblastoma 209 | 5,635
atypical teratoid / rhabdoid tumor 176 | 4,971
lung cancer 174 | 4,607
ependymoma 171 | 4,559
adult high grade glioma 137 | 3,701
group 3 medulloblastoma 137 | 4,002
intraductal papillary-mucinous neoplasm (IPMN) 128 | 3,204
malignant mesothelioma 125 | 3,135
intraductal papillary-mucinous carcinoma (IPMC) 115 | 2,902
Breast cancer 112 | 3,469
Astrocytoma, Pilocytic 111 | 3,006
intraductal papillary-mucinous adenoma (IPMA) 108 | 2,872
invasive ductal carcinoma 105 | 2,867
lung adenocarcinoma 101 | 2,627
primitive neuroectodermal tumor 99 | 2,957
non-small cell lung cancer 97 | 2,799
oligodendroglioma 90 | 2,768
astrocytic glioma 88 | 2,530
Autosomal recessive predisposition 81 | 1,407
Cancer 81 | 2,388
pancreatic cancer 81 | 2,322
pancreatic ductal adenocarcinoma liver metastasis 81 | 1,911
subependymal giant cell astrocytoma 79 | 2,230
Kidney cancer 77 | 2,548
interstitial cystitis 77 | 2,237
lung carcinoma 77 | 2,755
tuberculosis 73 | 1,963
group 4 medulloblastoma 72 | 1,806
Pick disease 65 | 1,856
ductal carcinoma in situ 63 | 1,686
Multiple myeloma 62 | 1,296
pituitary cancer 62 | 1,915
ulcerative colitis 60 | 1,765
adrenocortical carcinoma 59 | 1,385
cystic fibrosis 58 | 1,629
breast carcinoma 57 | 1,589
Schizophrenia 50 | 1,136
astrocytoma 49 | 1,113
colon cancer 48 | 1,428
diabetes mellitus 47 | 1,683
Intellectual disability 45 | 998
Muscle hypotonia 44 | 562
Rheumatoid arthritis 41 | 1,156
Waldenstrons macroglobulinemia 41 | 742
Epilepsy 39 | 775
nasopharyngeal carcinoma 39 | 1,024
Atopic dermatitis 37 | 915
Seizures 37 | 584
active Crohn's disease 37 | 882
juvenile dermatomyositis 37 | 1,147
primary pancreatic ductal adenocarcinoma 36 | 1,071
Cognitive delay 34 | 596
Global developmental delay 34 | 596
Mental and motor retardation 34 | 596
acute myeloid leukemia 34 | 760
esophageal adenocarcinoma 34 | 696
Dull intelligence 33 | 634
Low intelligence 33 | 634
Mental Retardation 33 | 634
Mental deficiency 33 | 634
Poor school performance 33 | 634
acute quadriplegic myopathy 33 | 1,133
pediatric high grade glioma 33 | 1,035
gastric carcinoma 31 | 781
medulloblastoma 31 | 702
progressive supranuclear palsy 31 | 656
Alzheimer's disease 30 | 640
non primary Sjogren syndrome sicca 30 | 861
Obesity 29 | 655
aldosterone-producing adenoma 29 | 646
cutaneous lupus erythematosus 29 | 1,016
dermatomyositis 28 | 941
Liver Cirrhosis, Experimental 27 | 733
fibroadenoma 27 | 538
primary Sjogren syndrome 27 | 710
Failure to gain weight 24 | 359
Pediatric failure to thrive 24 | 359
Small head 23 | 366
Neurodegenerative disease 22 | 402
spina bifida 22 | 1,053
active ulcerative colitis 21 | 736
hepatocellular carcinoma 21 | 536
Endometriosis 20 | 521
Myopathy 20 | 185
Prostatic Neoplasms 20 | 472
Renal Cell Carcinoma 20 | 211
Short stature 20 | 514
Bipolar Disorder 19 | 646
Down syndrome 19 | 480
Hepatomegaly 18 | 280
Amyotrophic lateral sclerosis 17 | 437
Cerebellar Ataxia 17 | 302
atypical teratoid/rhabdoid tumor 17 | 349
pancreatic carcinoma 17 | 555
tuberculosis and treatment for 6 months 17 | 399

Tissue

Endocrine System 604 | 18,159
Skin and soft tissues 596 | 17,230
Female tissues 595 | 17,400
Digestive Tract 593 | 17,369
Male tissues 589 | 17,142
Liver and Pancreas 588 | 16,750
Blood and immune system 587 | 16,909
Nervous System 583 | 16,725
Urinary Tract 578 | 16,678
Respiratory system 575 | 16,393
Cardiovascular System 551 | 15,192

Target Family

Enzyme 342 | 4,145
Kinase 238 | 634
Non-IDG 30 | 12,091
Epigenetic 10 | 242

PANTHER Protein Class (0)

transferase 620 | 620
nucleic acid binding 995 | 995
transcription factor 989 | 989
enzyme modulator 585 | 585
transporter 574 | 574
signaling molecule 554 | 554
hydrolase 464 | 464
cytoskeletal protein 441 | 441
receptor 400 | 400
oxidoreductase 319 | 319
membrane traffic protein 217 | 217
cell adhesion molecule 191 | 191
defense/immunity protein 177 | 177
extracellular matrix protein 175 | 175
ligase 175 | 175
transfer/carrier protein 175 | 175
calcium-binding protein 105 | 105
cell junction protein 90 | 90
chaperone 89 | 89
isomerase 84 | 84
lyase 64 | 64
transmembrane receptor regulat... 64 | 64
structural protein 45 | 45
storage protein 18 | 18
surfactant 8 | 8
viral protein 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glycogen debranching enzyme AGL Tbio Non-IDG -2.71712 509.7 141
Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A Tchem Kinase -2.68760 506.6 336
Exostosin-1 EXT1 Tbio Enzyme -2.68804 491.2 178
Patatin-like phospholipase domain-containing protein 2 PNPLA2 Tchem Enzyme -2.68285 486.4 398
Exostosin-like 3 EXTL3 Tbio Enzyme -2.69110 483.9 208
Protein-glutamine gamma-glutamyltransferase E TGM3 Tchem Enzyme -2.69033 481.2 236
Serine--pyruvate aminotransferase AGXT Tbio Enzyme -2.67998 477.5 182
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 Tbio Enzyme -2.69474 462.3 148
Deoxycytidine kinase DCK Tchem Kinase -2.63558 455.4 434
Arachidonate 5-lipoxygenase-activating protein ALOX5AP Tchem Enzyme -2.68134 446.8 174