Development Level

Tbio 49 | 11,445
Tchem 11 | 1,598
Tdark 5 | 6,588
Tclin 3 | 613

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

decreased circulating HDL chol... 68 | 68
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 51 | 11,493
medulloblastoma, large-cell 37 | 6,241
osteosarcoma 37 | 7,950
ovarian cancer 37 | 8,520
atypical teratoid / rhabdoid tumor 31 | 5,112
psoriasis 31 | 6,694
glioblastoma 27 | 5,792
ependymoma 24 | 4,679
group 3 medulloblastoma 23 | 4,104
primitive neuroectodermal tumor 23 | 3,035
adult high grade glioma 21 | 3,801
lung cancer 21 | 4,740
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
non-small cell lung cancer 18 | 2,890
oligodendroglioma 18 | 2,850
Breast cancer 17 | 3,578
Kidney cancer 17 | 2,613
pancreatic cancer 17 | 2,398
astrocytic glioma 16 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
malignant mesothelioma 14 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
invasive ductal carcinoma 13 | 2,951
subependymal giant cell astrocytoma 13 | 2,287
Astrocytoma, Pilocytic 12 | 3,081
Cancer 12 | 2,499
ductal carcinoma in situ 11 | 1,745
lung carcinoma 11 | 2,843
Intellectual disability 10 | 1,016
Rheumatoid arthritis 10 | 1,191
breast carcinoma 10 | 1,638
cystic fibrosis 10 | 1,696
lung adenocarcinoma 10 | 2,716
pituitary cancer 10 | 1,972
Obesity 9 | 678
Pick disease 9 | 1,894
Schizophrenia 9 | 1,160
adrenocortical carcinoma 9 | 1,428
group 4 medulloblastoma 9 | 1,855
tuberculosis 9 | 2,010
Autosomal recessive predisposition 8 | 1,442
Bipolar Disorder 8 | 666
Liver Cirrhosis, Experimental 7 | 769
astrocytoma 7 | 1,146
diabetes mellitus 7 | 1,728
interstitial cystitis 7 | 2,312
juvenile dermatomyositis 7 | 1,187
pancreatic carcinoma 7 | 562
ulcerative colitis 7 | 1,819
Autistic Disorder 6 | 364
colon cancer 6 | 1,478
esophageal adenocarcinoma 6 | 737
non primary Sjogren syndrome sicca 6 | 891
spina bifida 6 | 1,074
Alzheimer's disease 5 | 658
Amyotrophic lateral sclerosis 5 | 451
Atopic dermatitis 5 | 952
Autism spectrum disorder 5 | 101
Depressive disorder 5 | 409
Epilepsy 5 | 792
Failure to gain weight 5 | 365
Liver disease 5 | 237
Muscle hypotonia 5 | 571
Osteoporosis 5 | 363
Pediatric failure to thrive 5 | 365
acute myeloid leukemia 5 | 783
acute quadriplegic myopathy 5 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
cutaneous lupus erythematosus 5 | 1,057
nasopharyngeal carcinoma 5 | 1,058
Acquired metabolic disease 4 | 336
Autism Spectrum Disorders 4 | 75
Cerebrovascular disease 4 | 238
Dull intelligence 4 | 645
Endometrial cancer 4 | 311
Hyperreflexia 4 | 209
Kidney disease 4 | 430
Liver cancer 4 | 604
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Multiple myeloma 4 | 1,332
Muscle Spasticity 4 | 195
Poor school performance 4 | 645
Strabismus 4 | 270
active ulcerative colitis 4 | 764
hereditary spastic paraplegia 4 | 318
pediatric high grade glioma 4 | 1,064
primary Sjogren syndrome 4 | 735
primary pancreatic ductal adenocarcinoma 4 | 1,109
tuberculosis and treatment for 6 months 4 | 409
Arthritis, Rheumatoid 3 | 174
Attention deficit hyperactivity disorder 3 | 278
Duchenne muscular dystrophy 3 | 601
Prostatic Neoplasms 3 | 495
aldosterone-producing adenoma 3 | 665
dermatomyositis 3 | 966
gastric carcinoma 3 | 807
nephrosclerosis 3 | 333

Tissue

Female tissues 67 | 17,400
Blood and immune system 66 | 16,909
Digestive Tract 66 | 17,369
Endocrine System 66 | 18,159
Liver and Pancreas 66 | 16,750
Nervous System 66 | 16,725
Skin and soft tissues 66 | 17,230
Male tissues 65 | 17,142
Respiratory system 65 | 16,393
Urinary Tract 65 | 16,678
Cardiovascular System 63 | 15,192

Target Family

Non-IDG 35 | 12,091
Enzyme 20 | 4,145
Epigenetic 5 | 242
Transcription Factor 3 | 1,400
Kinase 2 | 634
GPCR 1 | 408
Ion Channel 1 | 344
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability