Development Level

Tbio 9,363 | 10,625
Tdark 4,471 | 7,003
Tchem 1,642 | 1,890
Tclin 471 | 602

Collection

Eligible Kinase Proteins 122 | 134
Eligible Ion Channel Proteins 82 | 117
Eligible non-olfactory GPCR Proteins 81 | 145

IMPC Term

preweaning lethality, complete... 610 | 633
preweaning lethality, incomple... 239 | 260
abnormal behavior 208 | 226
decreased lean body mass 182 | 195
embryonic lethality prior to t... 182 | 187
decreased total body fat amoun... 176 | 186
decreased body weight 164 | 174
embryonic lethality prior to o... 147 | 148
decreased bone mineral content 145 | 157
abnormal bone structure 117 | 131
decreased bone mineral density 115 | 126
increased or absent threshold ... 115 | 128
increased circulating alkaline... 114 | 119
decreased grip strength 110 | 123
decreased body length 106 | 108
abnormal embryo size 105 | 112
decreased circulating glucose ... 104 | 121
hyperactivity 100 | 108
abnormal retina morphology 95 | 100
enlarged heart 94 | 111
increased lean body mass 93 | 107
increased mean corpuscular hem... 89 | 93
increased mean corpuscular vol... 85 | 91
increased bone mineral content 84 | 92
hypoactivity 81 | 89
decreased circulating choleste... 80 | 85
decreased circulating triglyce... 77 | 83
short tibia 75 | 82
increased grip strength 73 | 83
decreased circulating HDL chol... 72 | 77
decreased circulating serum al... 68 | 79
abnormal lens morphology 66 | 73
decreased circulating insulin ... 63 | 75
increased fasted circulating g... 63 | 68
prenatal lethality prior to he... 62 | 64
decreased lumbar vertebrae num... 60 | 62
increased circulating sodium l... 59 | 71
increased sacral vertebrae num... 59 | 62
abnormal retinal pigmentation 57 | 61
abnormal sleep behavior 55 | 63
decreased rib number 55 | 59
increased circulating HDL chol... 54 | 63
male infertility 54 | 62
abnormal bone mineralization 53 | 55
abnormal coat/hair pigmentatio... 51 | 54
increased total body fat amoun... 51 | 57
decreased mean corpuscular vol... 49 | 50
increased bone mineral density 49 | 52
decreased hemoglobin content 48 | 53
decreased prepulse inhibition 48 | 52
increased circulating choleste... 48 | 53
increased exploration in new e... 48 | 56
decreased leukocyte cell numbe... 47 | 54
improved glucose tolerance 47 | 56
impaired glucose tolerance 46 | 52
abnormal behavioral response t... 45 | 52
abnormal gait 45 | 51
decreased caudal vertebrae num... 45 | 49
decreased circulating alanine ... 45 | 53
decreased startle reflex 44 | 48
abnormal heart morphology 43 | 51
decreased erythrocyte cell num... 43 | 43
decreased fasted circulating g... 42 | 49
thrombocytopenia 42 | 46
increased body weight 41 | 42
increased blood urea nitrogen ... 40 | 44
increased hemoglobin content 39 | 45
decreased circulating total pr... 38 | 41
decreased eosinophil cell numb... 38 | 41
decreased heart weight 38 | 44
increased rib number 38 | 41
decreased circulating alkaline... 37 | 41
abnormal eye morphology 36 | 38
abnormal seminal vesicle morph... 36 | 47
increased circulating chloride... 36 | 43
decreased circulating free fat... 35 | 39
increased leukocyte cell numbe... 35 | 37
abnormal neural tube closure 34 | 37
decreased circulating LDL chol... 34 | 37
decreased neutrophil cell numb... 34 | 37
limb grasping 34 | 35
small testis 34 | 37
decreased mean corpuscular hem... 33 | 34
increased heart weight 32 | 37
tremors 32 | 34
abnormal cranium morphology 31 | 32
increased hematocrit 31 | 36
increased startle reflex 31 | 38
abnormal spleen morphology 30 | 36
decreased T cell number 30 | 31
decreased circulating chloride... 29 | 32
decreased circulating creatini... 29 | 31
decreased circulating fructosa... 29 | 31
abnormal testis morphology 28 | 30
cardiovascular system phenotyp... 28 | 35
decreased circulating calcium ... 28 | 33
abnormal epididymis morphology 27 | 31
embryonic growth retardation 27 | 28
female infertility 27 | 34
increased circulating calcium ... 27 | 32

Disease

ovarian cancer 7,888 | 8,492
osteosarcoma 7,266 | 7,933
medulloblastoma, large-cell 5,614 | 6,234
psoriasis 5,609 | 6,685
glioblastoma 5,082 | 5,572
lung cancer 4,149 | 4,473
atypical teratoid / rhabdoid tumor 3,963 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,025 | 3,289
malignant mesothelioma 3,001 | 3,163
Breast cancer 2,842 | 3,099
primitive neuroectodermal tumor 2,737 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,726 | 2,988
pilocytic astrocytoma 2,711 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 2,690 | 2,956
invasive ductal carcinoma 2,682 | 2,950
non-small cell lung cancer 2,533 | 2,798
oligodendroglioma 2,533 | 2,849
pediatric high grade glioma 2,457 | 2,712
lung carcinoma 2,453 | 2,844
lung adenocarcinoma 2,389 | 2,714
ependymoma 2,300 | 2,514
pancreatic cancer 2,120 | 2,300
subependymal giant cell astrocytoma 2,089 | 2,287
Cancer 2,086 | 2,346
group 3 medulloblastoma 2,048 | 2,254
interstitial cystitis 2,017 | 2,299
astrocytic glioma 2,010 | 2,241
adult high grade glioma 1,888 | 2,148
ulcerative colitis 1,882 | 2,087
Carcinoma 1,751 | 2,147
Pick disease 1,743 | 1,893
pituitary cancer 1,735 | 1,972
group 4 medulloblastoma 1,719 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,668 | 1,795
ductal carcinoma in situ 1,574 | 1,745
cystic fibrosis 1,517 | 1,670
breast carcinoma 1,450 | 1,614
tuberculosis 1,434 | 1,563
astrocytoma 1,389 | 1,493
medulloblastoma 1,375 | 1,524
sonic hedgehog group medulloblastoma 1,346 | 1,482
posterior fossa group B ependymoma 1,337 | 1,530
posterior fossa group A ependymoma 1,329 | 1,511
diabetes mellitus 1,314 | 1,663
colon cancer 1,307 | 1,475
adrenocortical carcinoma 1,304 | 1,427
Multiple myeloma 1,296 | 1,328
primary pancreatic ductal adenocarcinoma 1,198 | 1,271
juvenile dermatomyositis 1,128 | 1,189
acute quadriplegic myopathy 1,093 | 1,157
Rheumatoid Arthritis 1,085 | 1,171
spina bifida 1,016 | 1,064
atypical teratoid/rhabdoid tumor 986 | 1,095
nasopharyngeal carcinoma 939 | 1,056
dermatomyositis 936 | 967
cutaneous lupus erythematosus 930 | 1,056
active Crohn's disease 829 | 918
Atopic dermatitis 786 | 944
gastric carcinoma 766 | 832
non primary Sjogren syndrome sicca 751 | 840
Waldenstrons macroglobulinemia 749 | 765
acute myeloid leukemia 748 | 785
primary Sjogren syndrome 727 | 789
esophageal adenocarcinoma 685 | 737
tuberculosis and treatment for 6 months 665 | 686
progressive supranuclear palsy 633 | 674
aldosterone-producing adenoma 603 | 664
Alzheimer's disease 558 | 644
Duchenne muscular dystrophy 537 | 602
Intellectual disability 529 | 573
pancreatic carcinoma 528 | 567
hepatocellular carcinoma 524 | 550
Obesity 506 | 616
Down syndrome 501 | 548
fibroadenoma 488 | 557
Endometriosis 474 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 457 | 499
chronic rhinosinusitis 444 | 512
Prostatic Neoplasms 431 | 471
active ulcerative colitis 429 | 477
IGA Glomerulonephritis 427 | 454
gastric cancer 411 | 436
Multiple Sclerosis 410 | 498
mucosa-associated lymphoid tissue lymphoma 404 | 480
Amyotrophic Lateral Sclerosis 397 | 432
Schizophrenia 388 | 503
Mammary Neoplasms 374 | 410
inflammatory breast cancer 363 | 404
Neurodegenerative disease 354 | 383
non-small cell lung carcinoma 339 | 413
sarcoidosis 333 | 368
glioblastoma multiforme 316 | 347
Kidney disease 311 | 397
Parkinson's disease 310 | 364
Polycystic Ovary Syndrome 306 | 335
tuberculosis and treatment for 3 months 304 | 327
hereditary spastic paraplegia 301 | 313
urothelial carcinoma 289 | 318
Asthma 277 | 349
nephrosclerosis 272 | 329

Tissue

Nervous System 15,713 | 18,561
Female tissues 15,699 | 18,647
Endocrine System 15,680 | 18,512
Digestive Tract 15,678 | 18,473
Urinary Tract 15,617 | 18,444
Liver and Pancreas 15,599 | 18,136
Male tissues 15,575 | 17,969
Cardiovascular System 15,538 | 17,958
Blood and immune system 15,536 | 17,995
Skin and soft tissues 15,503 | 18,115
Respiratory system 15,366 | 17,484

Target Family

Non-IDG 9,303 | 11,969
Enzyme 3,618 | 4,146
Transcription Factor 1,211 | 1,400
Kinase 590 | 634
Transporter 387 | 473
GPCR 265 | 408
Ion Channel 244 | 341
Epigenetic 223 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 35 | 38
oGPCR 29 | 421

HCA RNA Cell Line

A-431 15,947 | 15,947
U-2 OS 17,366 | 17,366
EFO-21 17,117 | 17,117
SCLC-21H 16,946 | 16,946
NTERA-2 16,846 | 16,846
U-266/70 16,556 | 16,556
BEWO 16,541 | 16,541
SH-SY5Y 16,521 | 16,521
HMC-1 16,394 | 16,394
NB-4 16,360 | 16,360
HaCaT 16,331 | 16,331
U-2197 16,301 | 16,301
U-266/84 16,257 | 16,257
U-251 MG 16,195 | 16,195
U-87 MG 16,106 | 16,106
Karpas-707 16,094 | 16,094
U-698 16,093 | 16,093
WM-115 16,065 | 16,065
K-562 16,049 | 16,049
T-47d 16,037 | 16,037
U-937 15,988 | 15,988
AF22 15,979 | 15,979
SK-MEL-30 15,962 | 15,962
CAPAN-2 15,918 | 15,918
RPMI-8226 15,832 | 15,832
SK-BR-3 15,827 | 15,827
REH 15,783 | 15,783
U-138 MG 15,734 | 15,734
HEK 293 15,668 | 15,668
THP-1 15,652 | 15,652
MOLT-4 15,626 | 15,626
HDLM-2 15,579 | 15,579
Daudi 15,575 | 15,575
RH-30 15,520 | 15,520
HeLa 15,516 | 15,516
RT4 15,502 | 15,502
AN3-CA 15,463 | 15,463
BJ hTERT+ SV40 Large T+ 15,430 | 15,430
BJ hTERT+ SV40 Large T+ RasG12... 15,312 | 15,312
BJ 15,277 | 15,277
HTCEpi 15,272 | 15,272
CACO-2 15,255 | 15,255
PC-3 15,204 | 15,204
BJ hTERT+ 15,182 | 15,182
HEL 15,175 | 15,175
SiHa 15,107 | 15,107
RPTEC TERT1 15,102 | 15,102
MCF7 15,049 | 15,049
HBF TERT88 15,033 | 15,033
Hep G2 15,000 | 15,000
A549 14,995 | 14,995
HL-60 14,864 | 14,864
LHCN-M2 14,817 | 14,817
ASC TERT1 14,671 | 14,671
HUVEC TERT2 14,544 | 14,544
TIME 14,297 | 14,297

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Integrator complex subunit 9 INTS9 Tdark Non-IDG -0.71181 4.56 74
Nucleosome assembly protein 1-like 4 NAP1L4 Tbio Non-IDG -0.83421 6.96 51
Uncharacterized protein CXorf49 CXorf49B Tdark Non-IDG 0.00000 0
Lipopolysaccharide-induced tumor necrosis factor-alpha factor LITAF Tbio Transcription Factor -2.00894 100.6 155
TM2 domain-containing protein 3 TM2D3 Tbio Non-IDG -0.76592 5.99 54
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.22772 1655.7 459
Solute carrier family 35 member F5 SLC35F5 Tdark Transporter -0.16961 0.61 58
Retinoic acid early transcript 1G protein RAET1G Tbio Non-IDG -0.73392 5.37 19
Pyroglutamyl-peptidase 1-like protein PGPEP1L Tdark Enzyme 0.00000 10
Bromodomain adjacent to zinc finger domain protein 2A BAZ2A Tchem TF/Epigenetic -2.05410 110.9 33