Development Level

Tbio 10,310 | 11,651
Tdark 4,114 | 6,593
Tchem 1,226 | 1,388
Tclin 481 | 612

Collection

Kinase: IDG Consortium (Target... 117 | 125
Ion Channel: IDG Consortium (T... 74 | 99
GPCR: IDG Consortium (Targets) 73 | 126
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 17 | 25

IMPC Phenotype

preweaning lethality, complete... 949 | 979
preweaning lethality, incomple... 465 | 499
embryonic lethality prior to t... 272 | 278
abnormal behavior 271 | 298
embryonic lethality prior to o... 236 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 187 | 207
enlarged heart 178 | 210
abnormal bone structure 166 | 187
decreased vertical activity 163 | 208
increased lean body mass 154 | 172
decreased body weight 152 | 161
abnormal heart morphology 141 | 162
hyperactivity 134 | 148
decreased bone mineral content 130 | 151
decreased lean body mass 118 | 135
hypoactivity 118 | 132
increased circulating alkaline... 116 | 122
increased total body fat amoun... 116 | 134
decreased circulating glucose ... 111 | 126
decreased bone mineral density 109 | 126
male infertility 106 | 123
decreased grip strength 103 | 116
increased startle reflex 103 | 112
embryonic growth retardation 102 | 106
increased bone mineral content 100 | 108
abnormal seminal vesicle morph... 95 | 114
decreased body length 92 | 101
increased or absent threshold ... 90 | 101
short tibia 90 | 97
increased mean corpuscular hem... 88 | 96
decreased circulating choleste... 86 | 93
cataract 85 | 92
increased mean corpuscular vol... 85 | 92
prenatal lethality prior to he... 84 | 87
abnormal lens morphology 77 | 81
decreased prepulse inhibition 77 | 82
decreased circulating triglyce... 74 | 79
decreased mean corpuscular vol... 74 | 79
decreased lymphocyte cell numb... 72 | 83
increased bone mineral density 71 | 72
decreased circulating serum al... 70 | 82
decreased startle reflex 70 | 75
increased circulating HDL chol... 70 | 80
increased fasted circulating g... 69 | 76
abnormal retina morphology 67 | 71
decreased circulating insulin ... 66 | 76
decreased leukocyte cell numbe... 66 | 73
improved glucose tolerance 66 | 79
abnormal eye morphology 64 | 68
small superior vagus ganglion 64 | 74
decreased circulating HDL chol... 63 | 68
decreased hemoglobin content 62 | 68
impaired glucose tolerance 62 | 75
abnormal gait 61 | 69
abnormal sleep behavior 61 | 70
abnormal behavioral response t... 60 | 66
abnormal coat-hair pigmentatio... 60 | 64
increased heart weight 59 | 62
decreased erythrocyte cell num... 58 | 62
increased circulating choleste... 58 | 66
increased circulating sodium l... 58 | 71
edema 57 | 59
decreased fasted circulating g... 56 | 65
abnormal kidney morphology 54 | 65
increased monocyte cell number 54 | 63
small testis 53 | 58
decreased caudal vertebrae num... 50 | 53
thrombocytopenia 50 | 56
abnormal spleen morphology 49 | 55
female infertility 48 | 60
decreased mean corpuscular hem... 47 | 50
hydrometra 46 | 53
abnormal neural tube closure 44 | 46
abnormal skin morphology 44 | 50
decreased blood urea nitrogen ... 44 | 51
decreased circulating total pr... 44 | 49
decreased hematocrit 44 | 46
increased blood urea nitrogen ... 44 | 48
decreased circulating alanine ... 43 | 47
increased neutrophil cell numb... 43 | 46
decreased circulating alkaline... 42 | 46
increased leukocyte cell numbe... 42 | 47
increased hematocrit 41 | 46
increased mean platelet volume 40 | 45
limb grasping 40 | 41
abnormal testis morphology 39 | 43
enlarged spleen 39 | 41
increased hemoglobin content 39 | 45
decreased neutrophil cell numb... 38 | 42
increased circulating triglyce... 38 | 42
abnormal epididymis morphology 37 | 42
decreased red blood cell distr... 37 | 41
tremors 37 | 39
abnormal bone mineralization 36 | 38
increased grip strength 36 | 41
abnormal cranium morphology 35 | 36
decreased circulating LDL chol... 35 | 38
decreased circulating creatini... 35 | 39
enlarged lymph nodes 35 | 37

Disease

Carcinoma 9,744 | 11,493
ovarian cancer 7,998 | 8,520
osteosarcoma 7,354 | 7,950
medulloblastoma, large-cell 5,673 | 6,241
psoriasis 5,664 | 6,694
glioblastoma 5,330 | 5,792
atypical teratoid / rhabdoid tumor 4,676 | 5,112
lung cancer 4,356 | 4,740
ependymoma 4,232 | 4,679
group 3 medulloblastoma 3,741 | 4,104
adult high grade glioma 3,395 | 3,801
Breast cancer 3,265 | 3,578
malignant mesothelioma 3,082 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,055 | 3,291
primitive neuroectodermal tumor 2,773 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,750 | 2,989
Astrocytoma, Pilocytic 2,740 | 3,081
invasive ductal carcinoma 2,712 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,708 | 2,955
non-small cell lung cancer 2,628 | 2,890
oligodendroglioma 2,560 | 2,850
lung carcinoma 2,468 | 2,843
lung adenocarcinoma 2,411 | 2,716
astrocytic glioma 2,348 | 2,597
Cancer 2,237 | 2,499
Kidney cancer 2,212 | 2,613
pancreatic cancer 2,210 | 2,398
subependymal giant cell astrocytoma 2,108 | 2,287
interstitial cystitis 2,037 | 2,312
tuberculosis 1,868 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,848 | 1,962
Pick disease 1,759 | 1,894
pituitary cancer 1,749 | 1,972
group 4 medulloblastoma 1,733 | 1,855
ulcerative colitis 1,643 | 1,819
ductal carcinoma in situ 1,590 | 1,745
cystic fibrosis 1,551 | 1,696
breast carcinoma 1,486 | 1,638
diabetes mellitus 1,380 | 1,728
adrenocortical carcinoma 1,323 | 1,428
colon cancer 1,321 | 1,478
Multiple myeloma 1,310 | 1,332
Autosomal recessive predisposition 1,280 | 1,442
juvenile dermatomyositis 1,136 | 1,187
Rheumatoid arthritis 1,114 | 1,191
acute quadriplegic myopathy 1,102 | 1,158
astrocytoma 1,085 | 1,146
primary pancreatic ductal adenocarcinoma 1,049 | 1,109
spina bifida 1,035 | 1,074
pediatric high grade glioma 999 | 1,064
Schizophrenia 950 | 1,160
nasopharyngeal carcinoma 946 | 1,058
Intellectual disability 945 | 1,016
dermatomyositis 940 | 966
cutaneous lupus erythematosus 939 | 1,057
active Crohn's disease 838 | 922
non primary Sjogren syndrome sicca 809 | 891
Atopic dermatitis 801 | 952
acute myeloid leukemia 761 | 783
Waldenstrons macroglobulinemia 755 | 765
gastric carcinoma 748 | 807
Epilepsy 697 | 792
active ulcerative colitis 697 | 764
esophageal adenocarcinoma 688 | 737
Liver Cirrhosis, Experimental 687 | 769
primary Sjogren syndrome 682 | 735
medulloblastoma 668 | 720
progressive supranuclear palsy 639 | 676
aldosterone-producing adenoma 608 | 665
Dull intelligence 599 | 645
Low intelligence 599 | 645
Mental Retardation 599 | 645
Mental deficiency 599 | 645
Poor school performance 599 | 645
Cognitive delay 576 | 608
Global developmental delay 576 | 608
Mental and motor retardation 576 | 608
Alzheimer's disease 569 | 658
Obesity 561 | 678
Bipolar Disorder 543 | 666
Duchenne muscular dystrophy 543 | 601
Muscle hypotonia 540 | 571
Seizures 538 | 596
Melanoma 532 | 711
pancreatic carcinoma 527 | 562
hepatocellular carcinoma 523 | 547
Short stature 499 | 531
fibroadenoma 492 | 559
Endometriosis 485 | 540
Liver cancer 478 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 469 | 510
Down syndrome 461 | 499
Prostatic Neoplasms 456 | 495
Multiple Sclerosis 450 | 540
chronic rhinosinusitis 447 | 512
gastric cancer 437 | 459
posterior fossa group A ependymoma 430 | 468
sonic hedgehog group medulloblastoma 425 | 467
Amyotrophic lateral sclerosis 415 | 451
Breast Neoplasms 411 | 445

Tissue

Endocrine System 15,824 | 18,159
Female tissues 15,586 | 17,400
Digestive Tract 15,575 | 17,369
Skin and soft tissues 15,544 | 17,230
Male tissues 15,432 | 17,142
Blood and immune system 15,377 | 16,909
Nervous System 15,274 | 16,725
Liver and Pancreas 15,255 | 16,750
Urinary Tract 15,229 | 16,678
Respiratory system 15,102 | 16,393
Cardiovascular System 14,252 | 15,192

Target Family

Non-IDG 9,440 | 12,091
Enzyme 3,645 | 4,145
Transcription Factor 1,215 | 1,400
Kinase 596 | 634
Transporter 387 | 473
GPCR 264 | 408
Ion Channel 248 | 344
Epigenetic 229 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 36 | 38
oGPCR 29 | 421

HCA RNA Cell Line

A-431 16,131 | 16,131
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability