Development Level

Tbio 73 | 10,625
Tchem 47 | 1,890
Tclin 2 | 602
Tdark 2 | 7,003

Collection

Eligible Kinase Proteins 6 | 134

IMPC Term

preweaning lethality, complete... 9 | 633
embryonic lethality prior to o... 5 | 148
embryonic lethality prior to t... 3 | 187
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal lens morphology 2 | 73
abnormal maxilla morphology 2 | 16
abnormal tooth morphology 2 | 24
decreased T cell number 2 | 31
decreased circulating LDL chol... 2 | 37
decreased fasted circulating g... 2 | 49
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
enlarged spleen 2 | 26
hypoactivity 2 | 89
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased mean corpuscular vol... 2 | 91
increased mean platelet volume 2 | 19
abnormal behavioral response t... 1 | 52
abnormal blood vessel morpholo... 1 | 2
abnormal bone structure 1 | 131
abnormal coat/ hair morphology 1 | 18
abnormal locomotor activation 1 | 26
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
anophthalmia 1 | 20
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased CD5-positive Ly6C-po... 1 | 4
decreased CD8-positive, alpha-... 1 | 26
decreased CD8-positive, naive ... 1 | 5
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating amylase ... 1 | 24
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased circulating serum al... 1 | 79
decreased erythrocyte cell num... 1 | 43
decreased heart rate variabili... 1 | 11
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased respiratory quotient 1 | 12
enlarged heart 1 | 111
immune system phenotype 1 | 17
impaired glucose tolerance 1 | 52
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating bilirubi... 1 | 16
increased effector memory T-he... 1 | 5
increased glycosylated hemoglo... 1 | 1
increased grip strength 1 | 83
increased heart rate 1 | 17
increased heart weight 1 | 37
increased kidney weight 1 | 4
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased memory-marker gamma-... 1 | 2
increased monocyte cell number 1 | 27
increased neutrophil cell numb... 1 | 15
increased red blood cell distr... 1 | 21
increased spleen weight 1 | 3
shortened RR interval 1 | 19
tremors 1 | 34

Disease

osteosarcoma 78 | 7,933
ovarian cancer 70 | 8,484
medulloblastoma, large-cell 56 | 6,234
lung cancer 55 | 4,466
Cancer 51 | 2,346
glioblastoma 51 | 5,572
psoriasis 42 | 6,685
malignant mesothelioma 39 | 3,162
primitive neuroectodermal tumor 38 | 3,031
Breast cancer 32 | 3,094
atypical teratoid / rhabdoid tumor 32 | 4,369
group 3 medulloblastoma 30 | 2,254
oligodendroglioma 27 | 2,849
non-small cell lung cancer 26 | 2,798
pediatric high grade glioma 24 | 2,712
ependymoma 23 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,289
Carcinoma 21 | 2,147
adult high grade glioma 20 | 2,148
colon cancer 19 | 1,475
invasive ductal carcinoma 19 | 2,950
astrocytic glioma 17 | 2,241
pilocytic astrocytoma 17 | 3,086
atypical teratoid/rhabdoid tumor 16 | 1,095
subependymal giant cell astrocytoma 16 | 2,287
ductal carcinoma in situ 15 | 1,745
nasopharyngeal carcinoma 15 | 1,056
Mammary Neoplasms 14 | 410
adrenocortical carcinoma 14 | 1,427
diabetes mellitus 14 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
medulloblastoma 14 | 1,524
sonic hedgehog group medulloblastoma 14 | 1,482
Pick disease 13 | 1,893
group 4 medulloblastoma 13 | 1,875
posterior fossa group A ependymoma 13 | 1,511
astrocytoma 12 | 1,493
lung adenocarcinoma 12 | 2,713
Intellectual disability 11 | 573
Neoplastic Syndromes, Hereditary 11 | 48
Nijmegen breakage syndrome 11 | 23
acute quadriplegic myopathy 11 | 1,157
juvenile dermatomyositis 11 | 1,189
pituitary cancer 11 | 1,972
Ataxia telangiectasia 10 | 31
Peripheral Neuropathy 10 | 303
Rheumatoid Arthritis 10 | 1,160
lung carcinoma 10 | 2,844
Bloom syndrome 9 | 30
Endometriosis 9 | 535
Squamous cell carcinoma 9 | 94
Waldenstrons macroglobulinemia 9 | 765
non primary Sjogren syndrome sicca 9 | 840
Amyotrophic Lateral Sclerosis 8 | 431
Hereditary Breast and Ovarian Cancer Syndrome 8 | 14
Prostatic Neoplasms 8 | 471
interstitial cystitis 8 | 2,299
pancreatic cancer 8 | 2,300
tuberculosis and treatment for 6 months 8 | 686
ulcerative colitis 8 | 2,087
Alzheimer's disease 7 | 644
Colorectal Neoplasms 7 | 217
Fanconi's anemia 7 | 50
Lung Neoplasms 7 | 171
Melanoma 7 | 261
Seckel syndrome 7 | 34
acute myeloid leukemia 7 | 780
cutaneous lupus erythematosus 7 | 1,056
dermatomyositis 7 | 933
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
tuberculosis 7 | 1,557
Asthma 6 | 349
IGA Glomerulonephritis 6 | 454
Malignant neoplasm of breast 6 | 63
Microcephaly 6 | 149
Multiple myeloma 6 | 1,327
Prostate cancer 6 | 172
Renal Cell Carcinoma 6 | 199
Stomach Neoplasms 6 | 282
breast carcinoma 6 | 1,614
cystic fibrosis 6 | 1,665
posterior fossa group B ependymoma 6 | 1,530
Adenoid Cystic Carcinoma 5 | 99
Atopic dermatitis 5 | 944
Brain disease 5 | 83
Breast Cancer, Familial 5 | 12
Cardiomyopathies 5 | 90
Chronic Lymphocytic Leukemia 5 | 242
Epidermodysplasia verruciformis 5 | 21
Neurodegenerative disease 5 | 383
Pancreatic Neoplasm 5 | 79
Parkinson's disease 5 | 364
Schizophrenia 5 | 501
Skin Neoplasms 5 | 49
Werner syndrome 5 | 29
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
esophageal adenocarcinoma 5 | 737
progressive supranuclear palsy 5 | 674
primary pancreatic ductal adenocarcinoma 4 | 1,271

Tissue

Blood and immune system 124 | 17,995
Cardiovascular System 124 | 17,958
Digestive Tract 124 | 18,473
Endocrine System 124 | 18,512
Female tissues 124 | 18,647
Liver and Pancreas 124 | 18,136
Male tissues 124 | 17,969
Nervous System 124 | 18,561
Respiratory system 123 | 17,484
Urinary Tract 123 | 18,444
Skin and soft tissues 122 | 18,115

Target Family

Non-IDG 55 | 11,971
Kinase 28 | 634
Epigenetic 19 | 242
Enzyme 13 | 4,146
Transcription Factor 8 | 1,400
TF/Epigenetic 1 | 38

GO Process

regulation of signal transduct... 124 | 124
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.12937 142.2 263
BRCA1-associated RING domain protein 1 BARD1 Tbio Non-IDG -2.03629 111.2 208
Protein BANP BANP Tbio Non-IDG -1.62735 50.2 84
Cell cycle checkpoint control protein RAD9A RAD9A Tbio Non-IDG -2.13903 136.3 864
RelA-associated inhibitor PPP1R13L Tbio Non-IDG -1.62222 55.1 175
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.72596 5756.8 1322
POU domain, class 4, transcription factor 2 POU4F2 Tbio Transcription Factor -1.91904 86.9 136
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.45272 281.9 299
Chromodomain-helicase-DNA-binding protein 3 CHD3 Tbio Epigenetic -1.91070 82.8 185
DNA topoisomerase 3-alpha TOP3A Tbio Enzyme -2.66889 484.4 41