Development Level

Tchem 339 | 1,598
Tbio 122 | 11,445
Tclin 50 | 613
Tdark 24 | 6,588

Collection

Kinase: IDG Consortium (Target... 119 | 125
Kinase: IDG Consortium (Comple... 35 | 37

IMPC Phenotype

preweaning lethality, complete... 36 | 979
preweaning lethality, incomple... 28 | 499
abnormal embryo size 14 | 220
embryonic lethality prior to t... 13 | 278
embryonic lethality prior to o... 12 | 239
abnormal bone structure 11 | 187
abnormal behavior 8 | 298
enlarged heart 8 | 210
decreased vertical activity 7 | 208
decreased leukocyte cell numbe... 6 | 73
decreased lymphocyte cell numb... 6 | 83
decreased mean corpuscular vol... 6 | 79
decreased total body fat amoun... 6 | 207
abnormal seminal vesicle morph... 5 | 114
abnormal spleen morphology 5 | 55
decreased body weight 5 | 161
decreased circulating glucose ... 5 | 126
decreased prepulse inhibition 5 | 82
increased bone mineral content 5 | 108
increased circulating alkaline... 5 | 122
increased monocyte cell number 5 | 63
increased or absent threshold ... 5 | 101
abnormal behavioral response t... 4 | 66
abnormal gait 4 | 69
abnormal heart morphology 4 | 162
abnormal lens morphology 4 | 81
decreased blood urea nitrogen ... 4 | 51
decreased bone mineral content 4 | 151
decreased fasted circulating g... 4 | 65
decreased hematocrit 4 | 46
decreased hemoglobin content 4 | 68
decreased lean body mass 4 | 135
decreased mean corpuscular hem... 4 | 50
decreased startle reflex 4 | 75
embryonic growth retardation 4 | 106
enlarged spleen 4 | 41
increased circulating choleste... 4 | 66
increased heart weight 4 | 62
increased mean corpuscular vol... 4 | 92
increased total body fat amoun... 4 | 134
small testis 4 | 58
abnormal epididymis morphology 3 | 42
abnormal skin morphology 3 | 50
abnormal testis morphology 3 | 43
anophthalmia 3 | 33
decreased body length 3 | 101
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
decreased circulating magnesiu... 3 | 13
decreased circulating serum al... 3 | 82
decreased large unstained cell... 3 | 11
decreased neutrophil cell numb... 3 | 42
enlarged epididymis 3 | 31
enlarged lymph nodes 3 | 37
hyperactivity 3 | 148
improved glucose tolerance 3 | 79
increased blood urea nitrogen ... 3 | 48
increased bone mineral density 3 | 72
increased circulating HDL chol... 3 | 80
increased circulating LDL chol... 3 | 13
increased circulating iron lev... 3 | 30
increased circulating sodium l... 3 | 71
increased mean platelet volume 3 | 45
increased spleen weight 3 | 10
increased startle reflex 3 | 112
male infertility 3 | 123
microphthalmia 3 | 26
small superior vagus ganglion 3 | 74
abnormal bone mineralization 2 | 38
abnormal embryo turning 2 | 31
abnormal eye anterior chamber ... 2 | 9
abnormal eye morphology 2 | 68
abnormal femur morphology 2 | 14
abnormal joint morphology 2 | 23
abnormal kidney morphology 2 | 65
abnormal neural tube closure 2 | 46
abnormal pelvic girdle bone mo... 2 | 12
abnormal pericardium morpholog... 2 | 26
abnormal response to new envir... 2 | 10
abnormal retina morphology 2 | 71
cataract 2 | 92
decreased circulating HDL chol... 2 | 68
decreased circulating creatini... 2 | 39
decreased circulating iron lev... 2 | 32
decreased eosinophil cell numb... 2 | 24
decreased mean platelet volume 2 | 25
edema 2 | 59
impaired glucose tolerance 2 | 75
increased body length 2 | 32
increased circulating aspartat... 2 | 15
increased circulating calcium ... 2 | 34
increased erythrocyte cell num... 2 | 39
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased prepulse inhibition 2 | 32
increased red blood cell distr... 2 | 34
pallor 2 | 34
short tibia 2 | 97
thrombocytosis 2 | 27

Disease

Carcinoma 452 | 11,493
osteosarcoma 298 | 7,950
ovarian cancer 295 | 8,520
medulloblastoma, large-cell 236 | 6,241
psoriasis 219 | 6,694
glioblastoma 213 | 5,792
atypical teratoid / rhabdoid tumor 194 | 5,112
lung cancer 182 | 4,740
ependymoma 180 | 4,679
Cancer 175 | 2,499
Kidney cancer 159 | 2,613
group 3 medulloblastoma 147 | 4,104
adult high grade glioma 141 | 3,801
Breast cancer 139 | 3,578
malignant mesothelioma 139 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 136 | 3,291
non-small cell lung cancer 127 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 122 | 2,989
Astrocytoma, Pilocytic 120 | 3,081
primitive neuroectodermal tumor 118 | 3,035
oligodendroglioma 114 | 2,850
invasive ductal carcinoma 112 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 105 | 2,955
astrocytic glioma 103 | 2,597
lung carcinoma 103 | 2,843
lung adenocarcinoma 94 | 2,716
pancreatic cancer 93 | 2,398
Pick disease 81 | 1,894
subependymal giant cell astrocytoma 79 | 2,287
interstitial cystitis 78 | 2,312
group 4 medulloblastoma 77 | 1,855
cystic fibrosis 70 | 1,696
ulcerative colitis 70 | 1,819
tuberculosis 69 | 2,010
Renal Cell Carcinoma 68 | 214
pituitary cancer 68 | 1,972
ductal carcinoma in situ 65 | 1,745
adrenocortical carcinoma 62 | 1,428
breast carcinoma 62 | 1,638
diabetes mellitus 57 | 1,728
Autosomal recessive predisposition 56 | 1,442
Chronic Myelocytic Leukemia Accelerated Phase 55 | 59
Blastic phase chronic myeloid leukemia 54 | 58
Schizophrenia 54 | 1,160
colon cancer 53 | 1,478
Rheumatoid arthritis 50 | 1,191
astrocytoma 48 | 1,146
Gastrointestinal stromal tumor 47 | 62
Intellectual disability 47 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 46 | 1,962
spina bifida 46 | 1,074
Pancreatic Neuroendocrine Tumor 42 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 42 | 47
juvenile dermatomyositis 42 | 1,187
primary pancreatic ductal adenocarcinoma 42 | 1,109
Chronic phase chronic myeloid leukemia 41 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 41 | 45
Melanoma 39 | 711
acute quadriplegic myopathy 39 | 1,158
Liver cancer 38 | 604
pediatric high grade glioma 38 | 1,064
Dull intelligence 36 | 645
Low intelligence 36 | 645
Mental Retardation 36 | 645
Mental deficiency 36 | 645
Poor school performance 36 | 645
nasopharyngeal carcinoma 34 | 1,058
Atopic dermatitis 33 | 952
Hamman-Rich syndrome 33 | 34
Breast Neoplasms 32 | 445
Epilepsy 32 | 792
Skin cancer 32 | 469
Mammary Neoplasms 31 | 425
Multiple myeloma 31 | 1,332
cutaneous lupus erythematosus 31 | 1,057
Alzheimer's disease 30 | 658
dermatomyositis 30 | 966
progressive supranuclear palsy 30 | 676
esophageal adenocarcinoma 29 | 737
Bipolar Disorder 27 | 666
Down syndrome 27 | 499
Short stature 27 | 531
aldosterone-producing adenoma 27 | 665
Hypertension 26 | 396
Obesity 26 | 678
Parkinson's disease 26 | 392
Prostatic Neoplasms 26 | 495
acute myeloid leukemia 26 | 783
primary Sjogren syndrome 26 | 735
Cognitive delay 25 | 608
Global developmental delay 25 | 608
Hypoplastic mandible condyle 25 | 275
Mandibular hypoplasia 25 | 275
Mental and motor retardation 25 | 608
Micrognathism 25 | 275
medulloblastoma 25 | 720
Chronic Lymphocytic Leukemia 24 | 262
Depressive disorder 24 | 409
Small head 24 | 374
Waldenstrons macroglobulinemia 24 | 765

Tissue

Endocrine System 529 | 18,159
Digestive Tract 520 | 17,369
Skin and soft tissues 520 | 17,230
Female tissues 518 | 17,400
Male tissues 518 | 17,142
Blood and immune system 511 | 16,909
Liver and Pancreas 511 | 16,750
Nervous System 509 | 16,725
Urinary Tract 509 | 16,678
Respiratory system 507 | 16,393
Cardiovascular System 488 | 15,192

Target Family

Kinase 514 | 634
Enzyme 11 | 4,145
Non-IDG 10 | 12,091

DTO Protein Class (1)

Protein kinase 535 | 535
Class A rhodopsin like 749 | 749
Non-protein kinase 67 | 67
Potassium channel family 52 | 52
Neurotransmitter receptor, cys... 47 | 47
Adhesion class 33 | 33
Transient receptor potential c... 24 | 24
Class C metabotropic glutamate... 23 | 23
Glutamate-gated ion channel (... 19 | 19
Class B secretin like 16 | 16
Inward rectifier-type potassiu... 16 | 16
Two pore domain potassium chan... 15 | 15
Calcium channel alpha-1 subuni... 13 | 13
Class F frizzled-type 12 | 12
Cyclic nucleotide-gated cation... 10 | 10
Sodium channel family 10 | 10
Amiloride-sensitive sodium cha... 9 | 9
Chloride channel family 9 | 9
Calcium channel auxiliary subu... 8 | 8
3-ketosteroid receptors 7 | 7
Atp-gated p2x receptor cation ... 7 | 7
Intracellular chloride channel... 6 | 6
Polycystin cation channel (pcc... 6 | 6
Ryanodine-inositol 1,4,5-triph... 6 | 6
Transmembrane channel (TMC) fa... 6 | 6
Calcium-dependent chloride cha... 5 | 5
Fxyd family 5 | 5
Anion channel-forming bestroph... 4 | 4
Calcium channel auxiliary subu... 4 | 4
Calcium channel auxiliary subu... 4 | 4
Calcium homeostasis modulator ... 4 | 4
Calcium-activated potassium ch... 4 | 4
Cation channel sperm-associate... 4 | 4
Epithelial chloride channel (e... 4 | 4
Other 7TM proteins 4 | 4
Sodium channel auxiliary subun... 4 | 4
Vitamin d receptor-like recept... 4 | 4
Anion channel tweety (tweety) ... 3 | 3
Coup-tf-like receptors 3 | 3
Estrogen-related receptors 3 | 3
Gap junction-forming innexin (... 3 | 3
Liver x receptor-like receptor... 3 | 3
Nerve growth factor ib-like re... 3 | 3
Peroxisome proliferator-activa... 3 | 3
Phagocyte (gp91(phox)) nadph o... 3 | 3
Retinoic acid receptors 3 | 3
Retinoic acid-related orphans 3 | 3
Retinoid x receptors 3 | 3
Voltage-gated potassium channe... 3 | 3
Dax-like receptors 2 | 2
Estrogen receptors 2 | 2
FAM26 family 2 | 2
Fushi tarazu f1-like receptors 2 | 2
Golgi pH regulator family 2 | 2
Hepatocyte nuclear factor-4 re... 2 | 2
Mechanical nociceptor, piezo (... 2 | 2
Phospholemman (plm) family 2 | 2
Rev-erb receptors 2 | 2
SLC26A-SulP transporter family 2 | 2
Tailless-like receptors 2 | 2
Testicular receptors 2 | 2
Thyroid hormone receptors 2 | 2
Tmem38 family 2 | 2
Unclassified protein 2 | 2
ABCC family 1 | 1
Calcium release-activated calc... 1 | 1
Cation-nonselective channel fa... 1 | 1
Germ cell nuclear factor recep... 1 | 1
Intracellular chloride channel... 1 | 1
MCU family 1 | 1
Membrane protein mlc1 family 1 | 1
PMP-22-EMP-MP20 family 1 | 1
The phagocyte (gp91(phox)) nad... 1 | 1
Voltage-gated proton channel (... 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene tyrosine-protein kinase receptor Ret RET Tclin Kinase -3.42801 2821.4 880
Tyrosine-protein kinase Lyn LYN Tclin Kinase -2.83644 683.2 589
RAF proto-oncogene serine/threonine-protein kinase RAF1 Tclin Kinase -3.11577 1210.8 2254
Mitogen-activated protein kinase 11 MAPK11 Tchem Kinase -2.06160 98.6 336
Cyclin-dependent kinase 1 CDK1 Tchem Kinase -3.28086 1790.3 1933
5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 Tchem Kinase -1.92824 74.3 953
SNF-related serine/threonine-protein kinase SNRK Tbio Kinase -1.74114 51.4 123
Calcium/calmodulin-dependent protein kinase kinase 1 CAMKK1 Tchem Kinase -0.66066 4.10 152
Ephrin-A1 EFNA1 Tbio Kinase -2.02623 101.5 256
Tyrosine-protein kinase Yes YES1 Tclin Kinase -2.04081 103.6 419