Development Level

Tbio 1,339 | 11,651
Tdark 768 | 6,593
Tchem 186 | 1,388
Tclin 63 | 612

Collection

RFA-RM-18-021 9 | 328
Kinase: IDG Consortium (Target... 5 | 125
Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 110 | 979
preweaning lethality, incomple... 67 | 499
abnormal behavior 34 | 298
embryonic lethality prior to t... 32 | 278
decreased total body fat amoun... 29 | 207
abnormal embryo size 28 | 220
decreased body weight 27 | 161
increased lean body mass 27 | 172
abnormal bone structure 25 | 187
embryonic lethality prior to o... 25 | 239
hypoactivity 24 | 132
decreased vertical activity 21 | 208
abnormal heart morphology 19 | 162
enlarged heart 19 | 210
increased startle reflex 19 | 112
decreased bone mineral density 18 | 126
hyperactivity 17 | 148
male infertility 17 | 123
short tibia 16 | 97
abnormal seminal vesicle morph... 14 | 114
decreased circulating glucose ... 14 | 126
decreased lean body mass 14 | 135
increased bone mineral content 14 | 108
decreased body length 13 | 101
embryonic growth retardation 13 | 106
increased total body fat amoun... 13 | 134
prenatal lethality prior to he... 13 | 87
decreased bone mineral content 12 | 151
increased bone mineral density 12 | 72
increased circulating HDL chol... 12 | 80
increased mean corpuscular vol... 12 | 92
abnormal kidney morphology 11 | 65
decreased circulating serum al... 11 | 82
female infertility 11 | 60
impaired glucose tolerance 11 | 75
increased fasted circulating g... 11 | 76
cataract 10 | 92
decreased circulating choleste... 10 | 93
decreased grip strength 10 | 116
decreased prepulse inhibition 10 | 82
increased mean corpuscular hem... 10 | 96
abnormal eye morphology 9 | 68
abnormal spleen morphology 9 | 55
decreased circulating insulin ... 9 | 76
decreased circulating triglyce... 9 | 79
decreased mean corpuscular hem... 9 | 50
decreased mean corpuscular vol... 9 | 79
increased circulating choleste... 9 | 66
increased mean platelet volume 9 | 45
abnormal behavioral response t... 8 | 66
abnormal bone mineralization 8 | 38
abnormal neural tube closure 8 | 46
abnormal retina morphology 8 | 71
decreased blood urea nitrogen ... 8 | 51
decreased circulating total pr... 8 | 49
decreased heart left ventricle... 8 | 28
decreased hemoglobin content 8 | 68
decreased neutrophil cell numb... 8 | 42
increased hematocrit 8 | 46
increased or absent threshold ... 8 | 101
small testis 8 | 58
abnormal coat-hair pigmentatio... 7 | 64
abnormal gait 7 | 69
abnormal lens morphology 7 | 81
decreased caudal vertebrae num... 7 | 53
decreased circulating HDL chol... 7 | 68
decreased circulating alanine ... 7 | 47
decreased circulating aspartat... 7 | 34
decreased lymphocyte cell numb... 7 | 83
decreased red blood cell distr... 7 | 41
edema 7 | 59
increased circulating alkaline... 7 | 122
increased heart weight 7 | 62
small superior vagus ganglion 7 | 74
abnormal retinal blood vessel ... 6 | 26
abnormal testis morphology 6 | 43
corneal opacity 6 | 32
decreased circulating chloride... 6 | 30
decreased erythrocyte cell num... 6 | 62
decreased leukocyte cell numbe... 6 | 73
enlarged spleen 6 | 41
improved glucose tolerance 6 | 79
increased body length 6 | 32
increased circulating creatini... 6 | 38
increased circulating triglyce... 6 | 42
increased hemoglobin content 6 | 45
increased monocyte cell number 6 | 63
limb grasping 6 | 41
thin ventricular wall 6 | 24
abnormal skin morphology 5 | 50
abnormal sleep behavior 5 | 70
anophthalmia 5 | 33
decreased circulating LDL chol... 5 | 38
decreased circulating alkaline... 5 | 46
decreased circulating iron lev... 5 | 32
decreased fasted circulating g... 5 | 65
decreased hematocrit 5 | 46
decreased startle reflex 5 | 75
increased circulating chloride... 5 | 41
increased circulating sodium l... 5 | 71

Disease

Carcinoma 1,673 | 11,493
osteosarcoma 1,163 | 7,950
ovarian cancer 1,106 | 8,520
medulloblastoma, large-cell 787 | 6,241
psoriasis 732 | 6,694
glioblastoma 708 | 5,792
atypical teratoid / rhabdoid tumor 642 | 5,112
lung cancer 586 | 4,740
group 3 medulloblastoma 568 | 4,104
ependymoma 510 | 4,679
adult high grade glioma 434 | 3,801
Kidney cancer 427 | 2,613
primitive neuroectodermal tumor 426 | 3,035
malignant mesothelioma 424 | 3,232
Breast cancer 417 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 392 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 366 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 362 | 2,989
oligodendroglioma 355 | 2,850
Cancer 325 | 2,499
invasive ductal carcinoma 311 | 2,951
Astrocytoma, Pilocytic 302 | 3,081
astrocytic glioma 301 | 2,597
group 4 medulloblastoma 296 | 1,855
non-small cell lung cancer 293 | 2,890
lung carcinoma 283 | 2,843
pancreatic cancer 276 | 2,398
subependymal giant cell astrocytoma 276 | 2,287
lung adenocarcinoma 250 | 2,716
Pick disease 237 | 1,894
tuberculosis 233 | 2,010
interstitial cystitis 215 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 211 | 1,962
pituitary cancer 205 | 1,972
ulcerative colitis 200 | 1,819
breast carcinoma 187 | 1,638
cystic fibrosis 186 | 1,696
ductal carcinoma in situ 181 | 1,745
adrenocortical carcinoma 180 | 1,428
juvenile dermatomyositis 176 | 1,187
astrocytoma 164 | 1,146
spina bifida 162 | 1,074
Rheumatoid arthritis 155 | 1,191
colon cancer 153 | 1,478
acute quadriplegic myopathy 150 | 1,158
diabetes mellitus 145 | 1,728
Multiple myeloma 137 | 1,332
Intellectual disability 136 | 1,016
primary pancreatic ductal adenocarcinoma 136 | 1,109
Autosomal recessive predisposition 128 | 1,442
pediatric high grade glioma 123 | 1,064
Schizophrenia 122 | 1,160
dermatomyositis 119 | 966
acute myeloid leukemia 116 | 783
cutaneous lupus erythematosus 114 | 1,057
non primary Sjogren syndrome sicca 111 | 891
active Crohn's disease 110 | 922
Atopic dermatitis 102 | 952
progressive supranuclear palsy 95 | 676
nasopharyngeal carcinoma 91 | 1,058
medulloblastoma 90 | 720
active ulcerative colitis 86 | 764
Liver cancer 85 | 604
gastric carcinoma 85 | 807
primary Sjogren syndrome 85 | 735
Short stature 84 | 531
Dull intelligence 81 | 645
Epilepsy 81 | 792
Low intelligence 81 | 645
Mental Retardation 81 | 645
Mental deficiency 81 | 645
Poor school performance 81 | 645
esophageal adenocarcinoma 81 | 737
Bipolar Disorder 79 | 666
Melanoma 78 | 711
hepatocellular carcinoma 77 | 547
tuberculosis and treatment for 6 months 77 | 409
Alzheimer's disease 76 | 658
Amyotrophic lateral sclerosis 75 | 451
Liver Cirrhosis, Experimental 74 | 769
aldosterone-producing adenoma 74 | 665
Cognitive delay 73 | 608
Global developmental delay 73 | 608
Mental and motor retardation 73 | 608
gastric cancer 73 | 459
Breast Neoplasms 72 | 445
Waldenstrons macroglobulinemia 71 | 765
Endometriosis 70 | 540
Mammary Neoplasms 69 | 425
Obesity 67 | 678
Muscle hypotonia 65 | 571
sonic hedgehog group medulloblastoma 65 | 467
Acquired metabolic disease 64 | 336
Prostatic Neoplasms 64 | 495
Seizures 61 | 596
pancreatic carcinoma 60 | 562
Down syndrome 59 | 499
autosomal dominant Emery-Dreifuss muscular dystrophy 57 | 510
atypical teratoid/rhabdoid tumor 55 | 357
mucosa-associated lymphoid tissue lymphoma 54 | 484

Tissue

Endocrine System 2,271 | 18,159
Female tissues 2,215 | 17,400
Digestive Tract 2,209 | 17,369
Skin and soft tissues 2,201 | 17,230
Male tissues 2,198 | 17,142
Nervous System 2,178 | 16,725
Blood and immune system 2,173 | 16,909
Liver and Pancreas 2,171 | 16,750
Urinary Tract 2,163 | 16,678
Respiratory system 2,142 | 16,393
Cardiovascular System 2,046 | 15,192

Target Family

Transcription Factor 747 | 1,400
Non-IDG 736 | 12,091
Enzyme 584 | 4,145
Epigenetic 131 | 242
Nuclear Receptor 46 | 48
Kinase 42 | 634
TF/Epigenetic 30 | 38
Transporter 25 | 473
Ion Channel 13 | 344
GPCR 2 | 408

UniProt Keyword

Zinc 2,356 | 2,356
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative N-acetylated-alpha-linked acidic dipeptidase FOLH1B Tbio Enzyme -3.08831 2219.0 0
Glutamate carboxypeptidase 2 FOLH1 Tchem Enzyme -3.08831 2219.0 855
Glutamate receptor ionotropic, NMDA 2B GRIN2B Tclin Ion Channel -3.32293 2085.7 980
Carbonic anhydrase 1 CA1 Tclin Enzyme -3.32406 2053.5 469
Early growth response protein 1 EGR1 Tbio Transcription Factor -3.29817 2034.6 394
Superoxide dismutase [Cu-Zn] SOD1 Tbio Enzyme -3.30643 1972.1 1103
Aminopeptidase N ANPEP Tchem Enzyme -3.28127 1843.4 1222
Phosphate-regulating neutral endopeptidase PHEX Tbio Enzyme -3.26526 1840.1 104
Stromelysin-1 MMP3 Tchem Non-IDG -3.28189 1799.2 1019
Zinc finger protein SNAI1 SNAI1 Tbio Transcription Factor -3.28636 1782.9 566