Development Level

Tbio 239 | 10,625
Tchem 99 | 1,890
Tdark 12 | 7,003
Tclin 6 | 602

Collection

Kinase: IDG Consortium (Targets) 4 | 125
Kinase: IDG Consortium (Complete/Control) 3 | 37

IMPC Phenotype

preweaning lethality, complete... 24 | 633
embryonic lethality prior to o... 11 | 148
embryonic lethality prior to t... 11 | 187
preweaning lethality, incomple... 6 | 260
abnormal behavior 5 | 226
increased mean corpuscular hem... 5 | 93
abnormal embryo size 4 | 112
abnormal lens morphology 4 | 73
decreased body length 4 | 108
decreased body weight 4 | 174
decreased circulating LDL chol... 4 | 37
decreased lean body mass 4 | 195
enlarged heart 4 | 111
increased exploration in new e... 4 | 56
abnormal skin coloration 3 | 18
cataract 3 | 26
decreased startle reflex 3 | 48
decreased total body fat amoun... 3 | 186
enlarged spleen 3 | 26
hypoactivity 3 | 89
increased circulating LDL chol... 3 | 15
increased circulating sodium l... 3 | 71
increased mean corpuscular vol... 3 | 91
pallor 3 | 13
prenatal lethality prior to he... 3 | 64
abnormal bone structure 2 | 131
abnormal epididymis morphology 2 | 31
abnormal heart morphology 2 | 51
abnormal limb bud morphology 2 | 15
abnormal maxilla morphology 2 | 16
abnormal placenta morphology 2 | 4
abnormal retina morphology 2 | 100
abnormal skin morphology 2 | 23
abnormal spleen morphology 2 | 36
abnormal tooth morphology 2 | 24
decreased T cell number 2 | 31
decreased blood urea nitrogen ... 2 | 31
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased erythrocyte cell num... 2 | 43
decreased fasted circulating g... 2 | 49
decreased mean corpuscular vol... 2 | 50
enlarged epididymis 2 | 27
hyperactivity 2 | 108
increased fasted circulating g... 2 | 68
increased grip strength 2 | 83
increased mean platelet volume 2 | 19
increased neutrophil cell numb... 2 | 15
male infertility 2 | 62
small testis 2 | 37
abnormal behavioral response t... 1 | 52
abnormal coat- hair morphology 1 | 18
abnormal cranium morphology 1 | 32
abnormal locomotor activation 1 | 26
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal retinal blood vessel ... 1 | 18
abnormal rib morphology 1 | 28
abnormal skin appearance 1 | 8
abnormal snout morphology 1 | 18
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 30
abnormal urinary bladder morph... 1 | 2
abnormal vertebrae morphology 1 | 14
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased CD8-positive, alpha-... 1 | 26
decreased KLRG1-positive NK ce... 1 | 9
decreased NK cell number 1 | 16
decreased anxiety-related resp... 1 | 12
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean platelet volume 1 | 12
decreased neutrophil cell numb... 1 | 37
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
embryonic growth retardation 1 | 28
enlarged lymph nodes 1 | 27
hemorrhage 1 | 12
hydrops fetalis 1 | 22
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased sacral vertebrae num... 1 | 62
prenatal lethality 1 | 16
short tibia 1 | 82
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 223 | 8,491
osteosarcoma 189 | 7,933
lung cancer 144 | 4,473
Cancer 142 | 2,346
medulloblastoma, large-cell 142 | 6,234
glioblastoma 134 | 5,572
psoriasis 133 | 6,685
malignant mesothelioma 90 | 3,163
atypical teratoid / rhabdoid tumor 87 | 4,369
Breast cancer 85 | 3,098
primitive neuroectodermal tumor 79 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 75 | 3,289
non-small cell lung cancer 72 | 2,798
group 3 medulloblastoma 68 | 2,254
oligodendroglioma 68 | 2,849
pediatric high grade glioma 60 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 59 | 2,988
ependymoma 58 | 2,514
astrocytic glioma 56 | 2,241
pancreatic cancer 54 | 2,300
lung adenocarcinoma 53 | 2,714
invasive ductal carcinoma 52 | 2,950
Carcinoma 50 | 2,147
subependymal giant cell astrocytoma 50 | 2,287
Multiple myeloma 47 | 1,327
adult high grade glioma 47 | 2,148
colon cancer 47 | 1,475
diabetes mellitus 45 | 1,663
Pick disease 43 | 1,893
group 4 medulloblastoma 43 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,956
adrenocortical carcinoma 42 | 1,427
pilocytic astrocytoma 42 | 3,086
pancreatic ductal adenocarcinoma liver metastasis 41 | 1,795
ductal carcinoma in situ 40 | 1,745
pituitary cancer 39 | 1,972
acute quadriplegic myopathy 37 | 1,157
medulloblastoma 37 | 1,524
tuberculosis 37 | 1,563
Waldenstrons macroglobulinemia 36 | 764
atypical teratoid/rhabdoid tumor 35 | 1,095
juvenile dermatomyositis 35 | 1,189
astrocytoma 34 | 1,493
ulcerative colitis 34 | 2,087
lung carcinoma 33 | 2,844
nasopharyngeal carcinoma 33 | 1,056
Rheumatoid Arthritis 31 | 1,170
breast carcinoma 29 | 1,614
Mammary Neoplasms 28 | 410
acute myeloid leukemia 28 | 785
primary pancreatic ductal adenocarcinoma 28 | 1,271
posterior fossa group A ependymoma 27 | 1,511
sonic hedgehog group medulloblastoma 27 | 1,482
non primary Sjogren syndrome sicca 26 | 840
Intellectual disability 25 | 573
dermatomyositis 25 | 966
interstitial cystitis 25 | 2,299
Endometriosis 23 | 535
tuberculosis and treatment for 6 months 22 | 686
Prostatic Neoplasms 21 | 471
pancreatic carcinoma 21 | 567
Atopic dermatitis 20 | 944
Peripheral Neuropathy 20 | 303
Stomach Neoplasms 20 | 282
cutaneous lupus erythematosus 20 | 1,056
gastric cancer 20 | 436
Alzheimer's disease 19 | 644
Lung Neoplasms 18 | 171
Neoplastic Syndromes, Hereditary 18 | 48
esophageal adenocarcinoma 18 | 737
Amyotrophic Lateral Sclerosis 17 | 432
Liver carcinoma 17 | 217
cystic fibrosis 17 | 1,670
gastric carcinoma 17 | 832
Melanoma 16 | 261
active Crohn's disease 16 | 918
hepatocellular carcinoma 16 | 550
Cockayne syndrome 15 | 54
IGA Glomerulonephritis 15 | 454
Obesity 15 | 616
Parkinson's disease 15 | 364
Renal Cell Carcinoma 14 | 199
Vascular disease 14 | 281
aldosterone-producing adenoma 14 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 14 | 499
chronic lymphocytic leukemia 14 | 244
ovarian neoplasm 14 | 97
posterior fossa group B ependymoma 14 | 1,530
spina bifida 14 | 1,064
Colorectal Neoplasms 13 | 217
Squamous cell carcinoma 13 | 96
progressive supranuclear palsy 13 | 674
Adenoma 12 | 165
Ataxia telangiectasia 12 | 32
Bloom syndrome 12 | 30
Kidney disease 12 | 397
Neurodegenerative disease 12 | 383
Polycystic Ovary Syndrome 12 | 334
cytochrome-c oxidase deficiency disease 12 | 19
primary Sjogren syndrome 12 | 788

Tissue

Blood and immune system 355 | 17,994
Digestive Tract 355 | 18,472
Endocrine System 355 | 18,511
Female tissues 355 | 18,646
Liver and Pancreas 355 | 18,135
Male tissues 355 | 17,968
Nervous System 355 | 18,560
Cardiovascular System 354 | 17,957
Respiratory system 354 | 17,483
Urinary Tract 354 | 18,443
Skin and soft tissues 351 | 18,114

Target Family

Non-IDG 179 | 11,969
Enzyme 88 | 4,146
Kinase 42 | 634
Epigenetic 24 | 242
Transcription Factor 21 | 1,400
TF/Epigenetic 2 | 38

Reactome Pathway

Transcriptional Regulation by ... 356 | 356
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 Tchem Kinase -1.87050 66.3 830
Cyclin-dependent kinase 1 CDK1 Tchem Kinase -3.25783 1710.8 1724
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.64263 41.9 218
Transcription factor E2F1 E2F1 Tchem Transcription Factor -2.27364 187.2 928
Mismatch repair endonuclease PMS2 PMS2 Tbio Enzyme -2.15128 309.3 303
Fructose-2,6-bisphosphatase TIGAR TIGAR Tbio Enzyme -1.66337 51.1 244
Negative elongation factor E NELFE Tbio Non-IDG -1.43797 27.6 85
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform PPP2R1A Tbio Enzyme -1.40388 25.3 259
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 17.1 179
Mitogen-activated protein kinase 11 MAPK11 Tchem Kinase -2.03896 96.9 275