Development Level

Tbio 263 | 11,651
Tchem 82 | 1,388
Tdark 14 | 6,593
Tclin 6 | 612

Collection

Kinase: IDG Consortium (Target... 4 | 125
RFA-RM-18-021 4 | 328
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 37 | 979
embryonic lethality prior to o... 18 | 239
preweaning lethality, incomple... 17 | 499
embryonic lethality prior to t... 16 | 278
abnormal embryo size 9 | 220
abnormal heart morphology 6 | 162
increased mean corpuscular hem... 6 | 96
enlarged heart 5 | 210
hyperactivity 5 | 148
abnormal behavior 4 | 298
abnormal lens morphology 4 | 81
cataract 4 | 92
decreased body weight 4 | 161
decreased circulating LDL chol... 4 | 38
decreased mean corpuscular vol... 4 | 79
increased lean body mass 4 | 172
increased startle reflex 4 | 112
pallor 4 | 34
prenatal lethality prior to he... 4 | 87
abnormal bone structure 3 | 187
abnormal embryo turning 3 | 31
abnormal lung morphology 3 | 26
abnormal retinal blood vessel ... 3 | 26
abnormal retinal vasculature m... 3 | 27
abnormal skin coloration 3 | 25
decreased caudal vertebrae num... 3 | 53
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased fasted circulating g... 3 | 65
decreased lean body mass 3 | 135
embryonic growth retardation 3 | 106
enlarged spleen 3 | 41
hypoactivity 3 | 132
increased circulating HDL chol... 3 | 80
increased circulating LDL chol... 3 | 13
increased circulating sodium l... 3 | 71
increased hemoglobin content 3 | 45
increased mean corpuscular vol... 3 | 92
increased mean platelet volume 3 | 45
male infertility 3 | 123
abnormal blood vessel morpholo... 2 | 5
abnormal epididymis morphology 2 | 42
abnormal hindbrain development 2 | 16
abnormal limb bud morphology 2 | 17
abnormal midbrain development 2 | 20
abnormal neural tube closure 2 | 46
abnormal placenta morphology 2 | 5
abnormal placenta size 2 | 20
abnormal retina morphology 2 | 71
abnormal skin morphology 2 | 50
abnormal spleen morphology 2 | 55
anophthalmia 2 | 33
cardiovascular system phenotyp... 2 | 36
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating serum al... 2 | 82
decreased erythrocyte cell num... 2 | 62
decreased mean platelet volume 2 | 25
decreased neutrophil cell numb... 2 | 42
decreased startle reflex 2 | 75
decreased vertical activity 2 | 208
edema 2 | 59
enlarged epididymis 2 | 31
hemorrhage 2 | 23
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating potassiu... 2 | 29
increased erythrocyte cell num... 2 | 39
increased fasted circulating g... 2 | 76
increased mean corpuscular hem... 2 | 36
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased total body fat amoun... 2 | 134
short tibia 2 | 97
small testis 2 | 58
tremors 2 | 39
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal optic disc morphology 1 | 10
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
decreased T cell number 1 | 15
decreased circulating amylase ... 1 | 28
decreased circulating potassiu... 1 | 20
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 31
impaired pupillary reflex 1 | 26
increased aggression 1 | 4
increased anti-nuclear antigen... 1 | 19
increased blood uric acid leve... 1 | 5
increased circulating phosphat... 1 | 26
increased heart weight 1 | 62
increased red blood cell distr... 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
vertebral fusion 1 | 23

Disease

ovarian cancer 230 | 8,520
Carcinoma 225 | 11,493
osteosarcoma 193 | 7,950
lung cancer 152 | 4,740
Cancer 148 | 2,499
medulloblastoma, large-cell 146 | 6,241
glioblastoma 144 | 5,792
psoriasis 137 | 6,694
atypical teratoid / rhabdoid tumor 120 | 5,112
group 3 medulloblastoma 108 | 4,104
Breast cancer 102 | 3,578
malignant mesothelioma 93 | 3,232
ependymoma 92 | 4,679
adult high grade glioma 85 | 3,801
primitive neuroectodermal tumor 80 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 76 | 3,291
non-small cell lung cancer 73 | 2,890
oligodendroglioma 68 | 2,850
astrocytic glioma 62 | 2,597
Kidney cancer 60 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 60 | 2,989
pancreatic cancer 56 | 2,398
invasive ductal carcinoma 54 | 2,951
lung adenocarcinoma 54 | 2,716
Multiple myeloma 51 | 1,332
diabetes mellitus 50 | 1,728
subependymal giant cell astrocytoma 50 | 2,287
tuberculosis 49 | 2,010
colon cancer 48 | 1,478
group 4 medulloblastoma 47 | 1,855
Intellectual disability 45 | 1,016
Astrocytoma, Pilocytic 44 | 3,081
Pick disease 43 | 1,894
adrenocortical carcinoma 43 | 1,428
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 43 | 1,962
Autosomal recessive predisposition 41 | 1,442
ductal carcinoma in situ 41 | 1,745
pituitary cancer 39 | 1,972
breast carcinoma 38 | 1,638
Waldenstrons macroglobulinemia 37 | 765
acute quadriplegic myopathy 37 | 1,158
juvenile dermatomyositis 36 | 1,187
lung carcinoma 33 | 2,843
nasopharyngeal carcinoma 33 | 1,058
Rheumatoid arthritis 32 | 1,191
Breast Neoplasms 31 | 445
Dull intelligence 31 | 645
Low intelligence 31 | 645
Mental Retardation 31 | 645
Mental deficiency 31 | 645
Poor school performance 31 | 645
astrocytoma 31 | 1,146
Schizophrenia 30 | 1,160
Epilepsy 29 | 792
Mammary Neoplasms 29 | 425
acute myeloid leukemia 29 | 783
ulcerative colitis 29 | 1,819
dermatomyositis 27 | 966
Cognitive delay 26 | 608
Global developmental delay 26 | 608
Mental and motor retardation 26 | 608
Seizures 26 | 596
Short stature 26 | 531
interstitial cystitis 26 | 2,312
non primary Sjogren syndrome sicca 26 | 891
pediatric high grade glioma 26 | 1,064
primary pancreatic ductal adenocarcinoma 26 | 1,109
Endometriosis 25 | 540
Stomach Neoplasms 25 | 300
Prostatic Neoplasms 23 | 495
medulloblastoma 22 | 720
Atopic dermatitis 21 | 952
Melanoma 21 | 711
Squamous cell carcinoma 21 | 129
Lung Neoplasms 20 | 232
cutaneous lupus erythematosus 20 | 1,057
Alzheimer's disease 19 | 658
Carcinoma, Hepatocellular 19 | 228
Cerebellar Ataxia 19 | 304
Muscle hypotonia 19 | 571
Small head 19 | 374
gastric cancer 19 | 459
Amyotrophic lateral sclerosis 18 | 451
Carcinoma, Squamous Cell 18 | 110
Cockayne syndrome 18 | 60
Liver carcinoma 18 | 240
Renal Cell Carcinoma 18 | 214
cystic fibrosis 18 | 1,696
esophageal adenocarcinoma 18 | 737
pancreatic carcinoma 18 | 562
gastric carcinoma 17 | 807
Anemia 16 | 365
active Crohn's disease 16 | 922
hepatocellular carcinoma 16 | 547
tuberculosis and treatment for 6 months 16 | 409
Hypoplastic mandible condyle 15 | 275
Mandibular hypoplasia 15 | 275
Micrognathism 15 | 275
Obesity 15 | 678

Tissue

Endocrine System 359 | 18,159
Digestive Tract 357 | 17,369
Female tissues 357 | 17,400
Skin and soft tissues 357 | 17,230
Blood and immune system 356 | 16,909
Male tissues 356 | 17,142
Nervous System 356 | 16,725
Liver and Pancreas 355 | 16,750
Respiratory system 355 | 16,393
Urinary Tract 355 | 16,678
Cardiovascular System 351 | 15,192

Target Family

Non-IDG 183 | 12,091
Enzyme 91 | 4,145
Kinase 42 | 634
Epigenetic 24 | 242
Transcription Factor 22 | 1,400
TF/Epigenetic 2 | 38
Transporter 1 | 473

Reactome Pathway

Transcriptional Regulation by ... 365 | 365
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inhibitor of growth protein 5 ING5 Tbio Epigenetic -1.34672 20.6 169
Target of rapamycin complex subunit LST8 MLST8 Tbio Non-IDG -2.64631 429.3 360
Bcl-2-binding component 3 BBC3 Tbio Non-IDG -2.02081 88.0 559
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058
Transcription elongation factor SPT4 SUPT4H1 Tbio Non-IDG -1.65513 43.4 92
Ragulator complex protein LAMTOR5 LAMTOR5 Tbio Non-IDG -2.24915 162.8 99
Insulin-like growth factor-binding protein 3 IGFBP3 Tchem Non-IDG -3.35760 2176.5 510
Protein arginine N-methyltransferase 1 PRMT1 Tchem Epigenetic -2.35804 229.5 394
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.76784 6081.3 1542
Trinucleotide repeat-containing gene 6B protein TNRC6B Tbio Non-IDG -1.06163 7.32 61