Development Level

Tdark 113 | 6,593
Tbio 95 | 11,651
Tchem 8 | 1,388

IMPC Phenotype

preweaning lethality, incomple... 8 | 499
preweaning lethality, complete... 6 | 979
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
decreased circulating insulin ... 3 | 76
decreased total body fat amoun... 3 | 207
embryonic lethality prior to t... 3 | 278
abnormal coat appearance 2 | 31
abnormal vibrissa morphology 2 | 25
decreased circulating HDL chol... 2 | 68
decreased circulating glucose ... 2 | 126
decreased fasted circulating g... 2 | 65
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
increased lean body mass 2 | 172
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
brachydactyly 1 | 19
cataract 1 | 92
convulsive seizures 1 | 13
corneal opacity 1 | 32
corneal vascularization 1 | 6
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased lean body mass 1 | 135
dilated heart left ventricle 1 | 11
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
male infertility 1 | 123
narrow eye opening 1 | 12
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small kidney 1 | 16

Disease

psoriasis 142 | 6,694
Carcinoma 100 | 11,493
diabetes mellitus 55 | 1,728
Atopic dermatitis 47 | 952
ovarian cancer 40 | 8,520
esophageal adenocarcinoma 32 | 737
cystic fibrosis 31 | 1,696
osteosarcoma 31 | 7,950
lung cancer 29 | 4,740
non-small cell lung cancer 29 | 2,890
Breast cancer 27 | 3,578
Cancer 25 | 2,499
spina bifida 25 | 1,074
medulloblastoma, large-cell 22 | 6,241
malignant mesothelioma 21 | 3,232
Palmoplantar keratosis 20 | 74
nasopharyngeal carcinoma 19 | 1,058
pancreatic cancer 19 | 2,398
interstitial cystitis 18 | 2,312
Kidney cancer 17 | 2,613
lung adenocarcinoma 16 | 2,716
Hypotrichosis 15 | 47
adult high grade glioma 15 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
Dystrophia unguium 13 | 53
breast carcinoma 13 | 1,638
Autosomal recessive predisposition 12 | 1,442
Congenital ichthyosiform erythroderma 12 | 28
cutaneous lupus erythematosus 12 | 1,057
ductal carcinoma in situ 12 | 1,745
Alopecia 11 | 115
Epidermolytic hyperkeratosis 11 | 14
Monilethrix 11 | 18
atypical teratoid / rhabdoid tumor 11 | 5,112
Abnormal blistering of the skin 10 | 54
Blister of skin 10 | 54
Dermatitis 10 | 157
Erythema 10 | 58
Flushing 10 | 60
Ichthyoses 10 | 41
Keratosis 10 | 37
Nail Diseases 10 | 24
Nail abnormality 10 | 22
Netherton syndrome 10 | 15
Pachyonychia congenita 10 | 10
Skin bulla 10 | 54
lung carcinoma 10 | 2,843
periodontitis 10 | 293
Hyperhidrosis disorder 9 | 81
Ichthyosis 9 | 56
Increased sweating 9 | 81
Skin cancer 9 | 469
Sweating 9 | 81
colon cancer 9 | 1,478
glioblastoma 9 | 5,792
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
Melanoma 8 | 711
Squamous cell carcinoma 8 | 129
ependymoma 8 | 4,679
invasive ductal carcinoma 8 | 2,951
ulcerative colitis 8 | 1,819
Arrhythmogenic right ventricular cardiomyopathy 7 | 30
Carcinoma, Squamous Cell 7 | 110
Eczema 7 | 45
Epidermolysis bullosa simplex 7 | 9
Hereditary mucosal leukokeratosis 7 | 7
Ichthyosis vulgaris 7 | 11
Leukokeratosis 7 | 19
Leukoplakia, Oral 7 | 20
Nail dysplasia 7 | 52
Peeling skin syndrome 7 | 17
Prostatic Neoplasms 7 | 495
group 3 medulloblastoma 7 | 4,104
pituitary cancer 7 | 1,972
primitive neuroectodermal tumor 7 | 3,035
Abnormality of metabolism/homeostasis 6 | 134
Asthma 6 | 385
Brittle hair 6 | 25
Cardiomyopathy 6 | 116
Fractured hair 6 | 25
Fragile hair 6 | 25
Onychogryposis 6 | 13
Papilloma 6 | 44
Pemphigus 6 | 23
Reduced tensile strength of hair 6 | 25
Skin disease 6 | 66
Wooly hair 6 | 17
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Astrocytoma, Pilocytic 5 | 3,081
Contact Dermatitis 5 | 81
Dermatitis, Contact 5 | 71
Dilated cardiomyopathy 5 | 56
Highly variable severity 5 | 157
Liver cancer 5 | 604
Malaria 5 | 160
Variable expressivity 5 | 157
active ulcerative colitis 5 | 764
oligodendroglioma 5 | 2,850
subependymal giant cell astrocytoma 5 | 2,287

Tissue

Skin and soft tissues 134 | 17,230
Female tissues 132 | 17,400
Endocrine System 118 | 18,159
Digestive Tract 117 | 17,369
Blood and immune system 108 | 16,909
Male tissues 81 | 17,142
Liver and Pancreas 76 | 16,750
Nervous System 72 | 16,725
Urinary Tract 69 | 16,678
Respiratory system 66 | 16,393
Cardiovascular System 52 | 15,192

Target Family

Non-IDG 197 | 12,091
Enzyme 19 | 4,145

Reactome Pathway

Keratinization 216 | 216
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability