Development Level

Tbio 82 | 11,178
Tchem 17 | 1,885
Tdark 17 | 6,569

IMPC Phenotype

preweaning lethality, complete... 24 | 979
abnormal embryo size 6 | 220
embryonic lethality prior to t... 6 | 278
abnormal behavior 3 | 298
abnormal lens morphology 3 | 81
cataract 3 | 92
decreased circulating alanine ... 3 | 47
decreased vertical activity 3 | 208
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
hyperactivity 3 | 148
preweaning lethality, incomple... 3 | 499
abnormal seminal vesicle morph... 2 | 114
cyanosis 2 | 7
decreased bone mineral content 2 | 151
decreased caudal vertebrae num... 2 | 53
decreased circulating aspartat... 2 | 34
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased grip strength 2 | 116
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
increased fasted circulating g... 2 | 76
increased grip strength 2 | 41
prenatal lethality prior to he... 2 | 87
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal kidney morphology 1 | 65
abnormal limb morphology 1 | 13
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal outer ear morphology 1 | 3
abnormal retina morphology 1 | 71
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased circulating free fat... 1 | 31
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased hematocrit 1 | 46
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
enlarged lymph nodes 1 | 37
enlarged seminal vesicle 1 | 10
hemorrhage 1 | 23
hydroencephaly 1 | 14
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
limb grasping 1 | 41
long tibia 1 | 25
male infertility 1 | 123
microphthalmia 1 | 26
prolonged PR interval 1 | 15
prolonged RR interval 1 | 8
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Carcinoma 76 | 11,192
ovarian cancer 73 | 8,297
glioblastoma 58 | 5,635
osteosarcoma 58 | 7,766
medulloblastoma, large-cell 51 | 6,086
atypical teratoid / rhabdoid tumor 48 | 4,971
lung cancer 42 | 4,607
ependymoma 40 | 4,559
group 3 medulloblastoma 40 | 4,002
Breast cancer 38 | 3,469
psoriasis 38 | 6,514
adult high grade glioma 36 | 3,701
malignant mesothelioma 29 | 3,135
primitive neuroectodermal tumor 28 | 2,957
non-small cell lung cancer 27 | 2,799
Astrocytoma, Pilocytic 25 | 3,006
lung adenocarcinoma 25 | 2,627
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,902
invasive ductal carcinoma 24 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,872
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,204
oligodendroglioma 21 | 2,768
Multiple myeloma 19 | 1,296
adrenocortical carcinoma 19 | 1,385
breast carcinoma 19 | 1,589
Kidney cancer 18 | 2,548
colon cancer 17 | 1,428
Pick disease 16 | 1,856
diabetes mellitus 16 | 1,683
astrocytic glioma 15 | 2,530
pancreatic cancer 15 | 2,322
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,911
astrocytoma 14 | 1,113
ductal carcinoma in situ 14 | 1,686
lung carcinoma 14 | 2,755
pituitary cancer 14 | 1,915
Atopic dermatitis 13 | 915
acute quadriplegic myopathy 13 | 1,133
dermatomyositis 13 | 941
group 4 medulloblastoma 12 | 1,806
pediatric high grade glioma 12 | 1,035
subependymal giant cell astrocytoma 12 | 2,230
juvenile dermatomyositis 11 | 1,147
Epilepsy 10 | 775
nasopharyngeal carcinoma 10 | 1,024
non primary Sjogren syndrome sicca 10 | 861
Cognitive delay 9 | 596
Endometriosis 9 | 521
Global developmental delay 9 | 596
Mental and motor retardation 9 | 596
Microcephaly 9 | 166
Muscle hypotonia 9 | 562
Neurodegenerative disease 9 | 402
Small head 9 | 366
Autosomal recessive predisposition 8 | 1,407
Intellectual disability 8 | 998
Seizures 8 | 584
active Crohn's disease 8 | 882
interstitial cystitis 8 | 2,237
spina bifida 8 | 1,053
tuberculosis 8 | 1,963
Anteverted nostril 7 | 186
Dull intelligence 7 | 634
Low intelligence 7 | 634
Mental Retardation 7 | 634
Mental deficiency 7 | 634
Neuropathy 7 | 254
Paraplegia 7 | 72
Poor school performance 7 | 634
Rheumatoid arthritis 7 | 1,156
Short nose 7 | 127
Small nose 7 | 127
tuberculosis and treatment for 6 months 7 | 399
Amyotrophic lateral sclerosis 6 | 437
Cancer 6 | 2,388
Cerebral atrophy 6 | 175
Endometrial cancer 6 | 301
Lissencephaly 6 | 69
Liver cancer 6 | 589
Muscle Spasticity 6 | 192
Optic Atrophy 6 | 239
Pachygyria 6 | 41
Schizophrenia 6 | 1,136
Short stature 6 | 514
cutaneous lupus erythematosus 6 | 1,016
hereditary spastic paraplegia 6 | 313
primary pancreatic ductal adenocarcinoma 6 | 1,071
Alzheimer's disease 5 | 640
Bipolar Disorder 5 | 646
Curvature of spine 5 | 275
Duchenne muscular dystrophy 5 | 587
Hypoplastic mandible condyle 5 | 273
Intrauterine retardation 5 | 174
Mandibular hypoplasia 5 | 273
Micrognathism 5 | 273
Waldenstrons macroglobulinemia 5 | 742
acute myeloid leukemia 5 | 760
cystic fibrosis 5 | 1,629
esophageal adenocarcinoma 5 | 696
pancreatic carcinoma 5 | 555

Tissue

Endocrine System 115 | 18,159
Digestive Tract 113 | 17,369
Female tissues 113 | 17,400
Liver and Pancreas 113 | 16,750
Male tissues 113 | 17,142
Skin and soft tissues 113 | 17,230
Urinary Tract 113 | 16,678
Blood and immune system 112 | 16,909
Nervous System 112 | 16,725
Respiratory system 112 | 16,393
Cardiovascular System 111 | 15,192

Target Family

Non-IDG 92 | 12,091
Enzyme 24 | 4,145

Reactome Pathway

Golgi-to-ER retrograde transpo... 116 | 116
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Chromosome-associated kinesin KIF4B KIF4B Tbio Non-IDG 0.01 1.04 3
Kinesin-like protein KIF26B KIF26B Tbio Non-IDG -0.94520 8.41 55
Kinesin-1 heavy chain KIF5B Tchem Non-IDG -2.32485 196.1 326
Cytosolic phospholipase A2 PLA2G4A Tchem Enzyme -2.68316 506.7 274
Vesicle-fusing ATPase NSF Tchem Enzyme -2.93271 688.8 206
Kinesin-like protein KIF25 KIF25 Tbio Non-IDG -0.75019 5.59 191
F-actin-capping protein subunit alpha-1 CAPZA1 Tbio Non-IDG -1.30282 20.8 170
Vesicle transport protein SEC20 BNIP1 Tbio Non-IDG -1.28198 20.1 370
ER lumen protein-retaining receptor 3 KDELR3 Tdark Non-IDG 0.40 0.12 65
Kinesin-like protein KIF13B KIF13B Tbio Non-IDG -1.34863 21.6 90