Development Level

Tbio 358 | 11,651
Tchem 181 | 1,388
Tdark 68 | 6,593
Tclin 18 | 612

Collection

Kinase: IDG Consortium (Target... 63 | 125
RFA-RM-18-021 63 | 328
Kinase: IDG Consortium (Comple... 22 | 37

IMPC Phenotype

preweaning lethality, complete... 46 | 979
preweaning lethality, incomple... 29 | 499
embryonic lethality prior to t... 18 | 278
embryonic lethality prior to o... 16 | 239
abnormal embryo size 11 | 220
abnormal behavior 9 | 298
enlarged heart 9 | 210
abnormal heart morphology 7 | 162
decreased circulating glucose ... 6 | 126
decreased lean body mass 6 | 135
increased monocyte cell number 6 | 63
increased or absent threshold ... 6 | 101
abnormal bone structure 5 | 187
abnormal kidney morphology 5 | 65
abnormal seminal vesicle morph... 5 | 114
decreased prepulse inhibition 5 | 82
decreased total body fat amoun... 5 | 207
decreased vertical activity 5 | 208
embryonic growth retardation 5 | 106
hypoactivity 5 | 132
increased bone mineral content 5 | 108
increased bone mineral density 5 | 72
increased lean body mass 5 | 172
increased mean corpuscular vol... 5 | 92
increased startle reflex 5 | 112
increased total body fat amoun... 5 | 134
abnormal eye morphology 4 | 68
abnormal neural tube closure 4 | 46
abnormal spleen morphology 4 | 55
decreased bone mineral content 4 | 151
decreased hemoglobin content 4 | 68
decreased lymphocyte cell numb... 4 | 83
decreased startle reflex 4 | 75
enlarged lymph nodes 4 | 37
hyperactivity 4 | 148
increased circulating alkaline... 4 | 122
microphthalmia 4 | 26
small superior vagus ganglion 4 | 74
abnormal coat-hair pigmentatio... 3 | 64
abnormal embryo turning 3 | 31
abnormal locomotor behavior 3 | 24
abnormal skin morphology 3 | 50
cataract 3 | 92
decreased body length 3 | 101
decreased body weight 3 | 161
decreased circulating creatini... 3 | 39
decreased circulating serum al... 3 | 82
decreased grip strength 3 | 116
decreased hematocrit 3 | 46
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
edema 3 | 59
enlarged spleen 3 | 41
hydrometra 3 | 53
improved glucose tolerance 3 | 79
increased body length 3 | 32
increased circulating sodium l... 3 | 71
male infertility 3 | 123
abnormal bone mineralization 2 | 38
abnormal epididymis morphology 2 | 42
abnormal forebrain development 2 | 20
abnormal lens morphology 2 | 81
abnormal midbrain development 2 | 20
abnormal sleep behavior 2 | 70
abnormal tail movements 2 | 12
abnormal tooth morphology 2 | 24
anophthalmia 2 | 33
decreased circulating fructosa... 2 | 30
decreased circulating glycerol... 2 | 16
decreased circulating insulin ... 2 | 76
decreased circulating magnesiu... 2 | 13
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased leukocyte cell numbe... 2 | 73
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
decreased total retina thickne... 2 | 17
enlarged epididymis 2 | 31
increased erythrocyte cell num... 2 | 39
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 96
increased prepulse inhibition 2 | 32
limb grasping 2 | 41
long tibia 2 | 25
persistence of hyaloid vascula... 2 | 33
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
short tibia 2 | 97
small seminal vesicle 2 | 10
small testis 2 | 58
abnormal retina morphology 1 | 71
abnormal vertebrae morphology 1 | 18
decreased circulating bilirubi... 1 | 19
decreased pulmonary respirator... 1 | 5
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
vertebral fusion 1 | 23

Disease

Carcinoma 423 | 11,493
ovarian cancer 319 | 8,520
osteosarcoma 299 | 7,950
psoriasis 253 | 6,694
medulloblastoma, large-cell 227 | 6,241
glioblastoma 212 | 5,792
atypical teratoid / rhabdoid tumor 179 | 5,112
ependymoma 176 | 4,679
lung cancer 174 | 4,740
adult high grade glioma 140 | 3,801
group 3 medulloblastoma 140 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 129 | 3,291
malignant mesothelioma 127 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 116 | 2,989
Astrocytoma, Pilocytic 115 | 3,081
Breast cancer 112 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 109 | 2,955
invasive ductal carcinoma 106 | 2,951
primitive neuroectodermal tumor 103 | 3,035
lung adenocarcinoma 101 | 2,716
non-small cell lung cancer 97 | 2,890
oligodendroglioma 93 | 2,850
astrocytic glioma 92 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 82 | 1,962
Autosomal recessive predisposition 81 | 1,442
Cancer 81 | 2,499
pancreatic cancer 81 | 2,398
subependymal giant cell astrocytoma 80 | 2,287
lung carcinoma 79 | 2,843
Kidney cancer 77 | 2,613
interstitial cystitis 77 | 2,312
tuberculosis 74 | 2,010
group 4 medulloblastoma 73 | 1,855
Pick disease 68 | 1,894
ductal carcinoma in situ 64 | 1,745
Multiple myeloma 62 | 1,332
pituitary cancer 62 | 1,972
ulcerative colitis 62 | 1,819
adrenocortical carcinoma 60 | 1,428
cystic fibrosis 59 | 1,696
breast carcinoma 57 | 1,638
Schizophrenia 50 | 1,160
astrocytoma 49 | 1,146
colon cancer 48 | 1,478
diabetes mellitus 48 | 1,728
Intellectual disability 45 | 1,016
Muscle hypotonia 44 | 571
Rheumatoid arthritis 42 | 1,191
Waldenstrons macroglobulinemia 41 | 765
Epilepsy 39 | 792
nasopharyngeal carcinoma 39 | 1,058
Atopic dermatitis 37 | 952
Seizures 37 | 596
active Crohn's disease 37 | 922
juvenile dermatomyositis 37 | 1,187
primary pancreatic ductal adenocarcinoma 36 | 1,109
Cognitive delay 34 | 608
Global developmental delay 34 | 608
Mental and motor retardation 34 | 608
acute myeloid leukemia 34 | 783
esophageal adenocarcinoma 34 | 737
pediatric high grade glioma 34 | 1,064
Dull intelligence 33 | 645
Low intelligence 33 | 645
Mental Retardation 33 | 645
Mental deficiency 33 | 645
Poor school performance 33 | 645
acute quadriplegic myopathy 33 | 1,158
progressive supranuclear palsy 32 | 676
gastric carcinoma 31 | 807
medulloblastoma 31 | 720
Alzheimer's disease 30 | 658
Obesity 30 | 678
non primary Sjogren syndrome sicca 30 | 891
aldosterone-producing adenoma 29 | 665
cutaneous lupus erythematosus 29 | 1,057
dermatomyositis 28 | 966
Liver Cirrhosis, Experimental 27 | 769
fibroadenoma 27 | 559
primary Sjogren syndrome 27 | 735
Failure to gain weight 24 | 365
Pediatric failure to thrive 24 | 365
Small head 23 | 374
Neurodegenerative disease 22 | 414
spina bifida 22 | 1,074
active ulcerative colitis 21 | 764
hepatocellular carcinoma 21 | 547
Endometriosis 20 | 540
Myopathy 20 | 185
Prostatic Neoplasms 20 | 495
Renal Cell Carcinoma 20 | 214
Short stature 20 | 531
Bipolar Disorder 19 | 666
Down syndrome 19 | 499
Amyotrophic lateral sclerosis 18 | 451
Hepatomegaly 18 | 285
Cerebellar Ataxia 17 | 304
atypical teratoid/rhabdoid tumor 17 | 357
pancreatic carcinoma 17 | 562
tuberculosis and treatment for 6 months 17 | 409

Tissue

Endocrine System 609 | 18,159
Skin and soft tissues 601 | 17,230
Female tissues 599 | 17,400
Digestive Tract 597 | 17,369
Male tissues 593 | 17,142
Liver and Pancreas 592 | 16,750
Blood and immune system 591 | 16,909
Nervous System 588 | 16,725
Urinary Tract 582 | 16,678
Respiratory system 579 | 16,393
Cardiovascular System 554 | 15,192

Target Family

Enzyme 342 | 4,145
Kinase 243 | 634
Non-IDG 30 | 12,091
Epigenetic 10 | 242

PANTHER Protein Class (0)

transferase 625 | 625
transcription factor 1,073 | 1,073
nucleic acid binding 1,006 | 1,006
hydrolase 762 | 762
enzyme modulator 645 | 645
transporter 580 | 580
signaling molecule 554 | 554
cytoskeletal protein 441 | 441
receptor 400 | 400
oxidoreductase 319 | 319
membrane traffic protein 217 | 217
cell adhesion molecule 191 | 191
ligase 191 | 191
defense/immunity protein 177 | 177
extracellular matrix protein 175 | 175
transfer/carrier protein 175 | 175
calcium-binding protein 105 | 105
cell junction protein 90 | 90
chaperone 89 | 89
isomerase 84 | 84
lyase 64 | 64
transmembrane receptor regulat... 64 | 64
structural protein 45 | 45
storage protein 18 | 18
surfactant 8 | 8
viral protein 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Creatine kinase B-type CKB Tbio Kinase -2.09121 122.4 465
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Serine/threonine-protein kinase TBK1 TBK1 Tchem Kinase -2.76728 569.1 455
Beta-adrenergic receptor kinase 1 GRK2 Tchem Kinase -2.61043 428.8 455
Eukaryotic translation initiation factor 2-alpha kinase 3 EIF2AK3 Tchem Kinase -3.05781 896.8 450