Development Level

Tbio 8,081 | 10,625
Tdark 3,411 | 7,003
Tchem 1,398 | 1,890
Tclin 407 | 602

Collection

Eligible Kinase Proteins 105 | 134
Eligible Ion Channel Proteins 44 | 117
Eligible non-olfactory GPCR Proteins 33 | 145

IMPC Term

preweaning lethality, complete... 570 | 633
preweaning lethality, incomple... 217 | 260
abnormal behavior 199 | 226
decreased lean body mass 171 | 195
embryonic lethality prior to t... 170 | 187
decreased total body fat amoun... 164 | 186
decreased body weight 154 | 174
embryonic lethality prior to o... 141 | 148
decreased bone mineral content 137 | 157
abnormal bone structure 106 | 131
decreased bone mineral density 106 | 126
increased circulating alkaline... 104 | 119
increased or absent threshold ... 102 | 128
abnormal embryo size 99 | 112
decreased circulating glucose ... 96 | 121
decreased body length 95 | 108
decreased grip strength 95 | 123
hyperactivity 93 | 108
increased lean body mass 93 | 107
abnormal retina morphology 87 | 100
increased mean corpuscular hem... 85 | 93
increased mean corpuscular vol... 82 | 91
increased bone mineral content 81 | 92
decreased circulating choleste... 79 | 85
enlarged heart 78 | 111
short tibia 73 | 82
decreased circulating HDL chol... 71 | 77
decreased circulating serum al... 71 | 79
hypoactivity 71 | 89
decreased circulating triglyce... 69 | 83
increased grip strength 66 | 83
abnormal lens morphology 59 | 73
increased fasted circulating g... 58 | 68
prenatal lethality prior to he... 57 | 64
decreased lumbar vertebrae num... 56 | 62
increased sacral vertebrae num... 55 | 62
increased circulating sodium l... 54 | 71
abnormal retinal pigmentation 53 | 61
decreased circulating insulin ... 53 | 75
abnormal sleep behavior 52 | 63
increased circulating HDL chol... 50 | 63
increased total body fat amoun... 50 | 57
decreased rib number 49 | 59
decreased leukocyte cell numbe... 48 | 54
increased circulating choleste... 48 | 53
decreased hemoglobin content 47 | 53
increased bone mineral density 47 | 52
abnormal bone mineralization 46 | 55
abnormal gait 46 | 51
decreased mean corpuscular vol... 46 | 50
male infertility 46 | 62
abnormal coat/hair pigmentatio... 45 | 54
impaired glucose tolerance 45 | 52
decreased prepulse inhibition 44 | 52
improved glucose tolerance 43 | 56
decreased circulating alanine ... 41 | 53
decreased caudal vertebrae num... 40 | 49
decreased erythrocyte cell num... 40 | 43
thrombocytopenia 40 | 46
abnormal behavioral response t... 39 | 52
decreased circulating total pr... 39 | 41
decreased fasted circulating g... 39 | 49
decreased startle reflex 38 | 48
decreased circulating LDL chol... 37 | 37
increased blood urea nitrogen ... 37 | 44
increased exploration in new e... 37 | 56
decreased heart weight 36 | 44
increased body weight 36 | 42
decreased neutrophil cell numb... 35 | 37
decreased eosinophil cell numb... 34 | 41
increased hemoglobin content 34 | 45
increased rib number 34 | 41
decreased circulating alkaline... 33 | 41
abnormal heart morphology 32 | 51
abnormal neural tube closure 32 | 37
decreased circulating free fat... 32 | 39
abnormal eye morphology 31 | 38
increased circulating chloride... 31 | 43
abnormal seminal vesicle morph... 30 | 47
decreased circulating calcium ... 30 | 33
decreased mean corpuscular hem... 30 | 34
increased hematocrit 30 | 36
increased startle reflex 30 | 38
tremors 30 | 34
abnormal cranium morphology 29 | 32
decreased circulating fructosa... 29 | 31
increased leukocyte cell numbe... 29 | 37
decreased T cell number 28 | 31
limb grasping 28 | 35
cardiovascular system phenotyp... 27 | 35
decreased circulating creatini... 27 | 31
increased circulating calcium ... 27 | 32
increased heart weight 27 | 37
small testis 27 | 37
increased circulating potassiu... 26 | 31
abnormal rib morphology 25 | 28
abnormal spleen morphology 25 | 36
decreased circulating aspartat... 25 | 27
decreased circulating chloride... 25 | 32
enlarged spleen 24 | 26

Disease

ovarian cancer 7,453 | 8,492
osteosarcoma 6,647 | 7,933
medulloblastoma, large-cell 5,165 | 6,234
glioblastoma 4,786 | 5,572
psoriasis 4,689 | 6,685
lung cancer 3,910 | 4,473
atypical teratoid / rhabdoid tumor 3,700 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,781 | 3,289
malignant mesothelioma 2,725 | 3,163
Breast cancer 2,623 | 3,099
invasive ductal carcinoma 2,576 | 2,950
pilocytic astrocytoma 2,568 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 2,559 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2,538 | 2,988
primitive neuroectodermal tumor 2,508 | 3,031
oligodendroglioma 2,421 | 2,849
lung carcinoma 2,368 | 2,844
non-small cell lung cancer 2,275 | 2,798
pediatric high grade glioma 2,269 | 2,712
ependymoma 2,184 | 2,514
lung adenocarcinoma 2,118 | 2,714
subependymal giant cell astrocytoma 2,048 | 2,287
astrocytic glioma 1,930 | 2,241
group 3 medulloblastoma 1,887 | 2,254
pancreatic cancer 1,875 | 2,300
interstitial cystitis 1,769 | 2,299
Pick disease 1,757 | 1,893
adult high grade glioma 1,753 | 2,148
Cancer 1,741 | 2,346
ulcerative colitis 1,712 | 2,087
group 4 medulloblastoma 1,663 | 1,875
pituitary cancer 1,642 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,581 | 1,795
Carcinoma 1,542 | 2,147
ductal carcinoma in situ 1,446 | 1,745
cystic fibrosis 1,359 | 1,670
astrocytoma 1,356 | 1,493
breast carcinoma 1,354 | 1,614
tuberculosis 1,354 | 1,563
adrenocortical carcinoma 1,298 | 1,427
Multiple myeloma 1,294 | 1,328
medulloblastoma 1,267 | 1,524
sonic hedgehog group medulloblastoma 1,251 | 1,482
posterior fossa group A ependymoma 1,218 | 1,511
colon cancer 1,217 | 1,475
posterior fossa group B ependymoma 1,211 | 1,530
primary pancreatic ductal adenocarcinoma 1,160 | 1,271
juvenile dermatomyositis 1,120 | 1,189
diabetes mellitus 1,107 | 1,663
acute quadriplegic myopathy 1,087 | 1,157
Rheumatoid Arthritis 981 | 1,171
dermatomyositis 899 | 967
atypical teratoid/rhabdoid tumor 884 | 1,095
spina bifida 853 | 1,064
cutaneous lupus erythematosus 851 | 1,056
nasopharyngeal carcinoma 746 | 1,056
gastric carcinoma 743 | 832
Waldenstrons macroglobulinemia 733 | 765
active Crohn's disease 723 | 918
acute myeloid leukemia 723 | 785
non primary Sjogren syndrome sicca 678 | 840
Atopic dermatitis 673 | 944
primary Sjogren syndrome 671 | 789
aldosterone-producing adenoma 653 | 664
tuberculosis and treatment for 6 months 648 | 686
progressive supranuclear palsy 621 | 674
esophageal adenocarcinoma 573 | 737
Duchenne muscular dystrophy 554 | 602
Alzheimer's disease 536 | 644
hepatocellular carcinoma 503 | 550
pancreatic carcinoma 493 | 567
Intellectual disability 490 | 573
Down syndrome 481 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 473 | 499
fibroadenoma 460 | 557
Obesity 457 | 616
IGA Glomerulonephritis 391 | 454
Prostatic Neoplasms 391 | 471
Amyotrophic Lateral Sclerosis 388 | 432
chronic rhinosinusitis 388 | 512
gastric cancer 388 | 436
Endometriosis 384 | 535
mucosa-associated lymphoid tissue lymphoma 378 | 480
Schizophrenia 360 | 503
active ulcerative colitis 357 | 477
Neurodegenerative disease 341 | 383
Mammary Neoplasms 331 | 410
Multiple Sclerosis 327 | 498
inflammatory breast cancer 318 | 404
hereditary spastic paraplegia 304 | 313
sarcoidosis 298 | 368
glioblastoma multiforme 294 | 347
tuberculosis and treatment for 3 months 284 | 327
Parkinson's disease 281 | 364
non-small cell lung carcinoma 271 | 413
Polycystic Ovary Syndrome 270 | 335
Kidney disease 256 | 397
interstitial lung disease 253 | 292
urothelial carcinoma 252 | 318
Epilepsy 249 | 346

Tissue

Endocrine System 13,297 | 18,512
Digestive Tract 13,294 | 18,473
Female tissues 13,294 | 18,647
Nervous System 13,293 | 18,561
Liver and Pancreas 13,289 | 18,136
Urinary Tract 13,289 | 18,444
Skin and soft tissues 13,288 | 18,115
Male tissues 13,279 | 17,969
Cardiovascular System 13,276 | 17,958
Blood and immune system 13,272 | 17,995
Respiratory system 13,262 | 17,484

Target Family

Non-IDG 7,653 | 11,969
Enzyme 3,246 | 4,146
Transcription Factor 967 | 1,400
Kinase 529 | 634
Transporter 304 | 473
Epigenetic 215 | 242
Ion Channel 164 | 341
GPCR 150 | 408
Nuclear Receptor 39 | 48
TF/Epigenetic 30 | 38

HPA RNA Tissue

adrenal gland 13,297 | 13,297
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
C-C motif chemokine 19 CCL19 Tbio Non-IDG -2.42216 231.6 229
Lipopolysaccharide-induced tumor necrosis factor-alpha factor LITAF Tbio Transcription Factor -2.00894 100.6 155
TM2 domain-containing protein 3 TM2D3 Tbio Non-IDG -0.76592 5.99 54
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.22772 1655.7 459
Solute carrier family 35 member F5 SLC35F5 Tdark Transporter -0.16961 0.61 58
Retinoic acid early transcript 1G protein RAET1G Tbio Non-IDG -0.73392 5.37 19
Bromodomain adjacent to zinc finger domain protein 2A BAZ2A Tchem TF/Epigenetic -2.05410 110.9 33
Ubiquinol-cytochrome-c reductase complex assembly factor 2 UQCC2 Tbio Enzyme -1.50813 29.9 15
Bromodomain adjacent to zinc finger domain protein 2B BAZ2B Tchem TF/Epigenetic -2.13444 130.1 74
Adenine DNA glycosylase MUTYH Tbio Enzyme -2.83418 699.9 239