Development Level

Tbio 10,156 | 11,445
Tdark 4,155 | 6,588
Tchem 1,405 | 1,598
Tclin 497 | 613

Collection

RFA-RM-18-021 253 | 328
Kinase: IDG Consortium (Target... 114 | 125
Ion Channel: IDG Consortium (T... 78 | 99
GPCR: IDG Consortium (Targets) 67 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 948 | 979
preweaning lethality, incomple... 463 | 499
abnormal behavior 280 | 298
embryonic lethality prior to t... 269 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 210 | 220
decreased total body fat amoun... 195 | 207
enlarged heart 177 | 210
abnormal bone structure 171 | 187
decreased vertical activity 170 | 208
increased lean body mass 159 | 172
decreased body weight 155 | 161
abnormal heart morphology 140 | 162
hyperactivity 137 | 148
decreased bone mineral content 131 | 151
decreased lean body mass 122 | 135
hypoactivity 119 | 132
increased total body fat amoun... 117 | 134
decreased circulating glucose ... 114 | 126
increased circulating alkaline... 114 | 122
decreased bone mineral density 108 | 126
male infertility 107 | 123
decreased grip strength 104 | 116
increased startle reflex 104 | 112
embryonic growth retardation 103 | 106
increased bone mineral content 99 | 108
abnormal seminal vesicle morph... 95 | 114
increased or absent threshold ... 93 | 101
decreased body length 92 | 101
short tibia 92 | 97
decreased circulating choleste... 90 | 93
increased mean corpuscular hem... 88 | 96
increased mean corpuscular vol... 86 | 92
cataract 85 | 92
prenatal lethality prior to he... 83 | 87
abnormal lens morphology 76 | 81
decreased lymphocyte cell numb... 76 | 83
decreased prepulse inhibition 75 | 82
decreased circulating triglyce... 74 | 79
decreased circulating serum al... 73 | 82
decreased mean corpuscular vol... 71 | 79
decreased startle reflex 71 | 75
increased fasted circulating g... 71 | 76
increased bone mineral density 70 | 72
decreased circulating insulin ... 69 | 76
impaired glucose tolerance 69 | 75
decreased leukocyte cell numbe... 68 | 73
decreased circulating HDL chol... 67 | 68
small superior vagus ganglion 67 | 74
abnormal eye morphology 66 | 68
abnormal retina morphology 65 | 71
increased circulating HDL chol... 65 | 80
improved glucose tolerance 64 | 79
increased circulating sodium l... 64 | 71
abnormal sleep behavior 62 | 70
increased heart weight 60 | 62
abnormal gait 59 | 69
decreased hemoglobin content 59 | 68
abnormal coat-hair pigmentatio... 58 | 64
decreased fasted circulating g... 58 | 65
abnormal behavioral response t... 57 | 66
abnormal kidney morphology 56 | 65
edema 56 | 59
increased circulating choleste... 56 | 66
decreased erythrocyte cell num... 55 | 62
increased monocyte cell number 55 | 63
small testis 54 | 58
abnormal spleen morphology 52 | 55
decreased caudal vertebrae num... 51 | 53
thrombocytopenia 50 | 56
decreased mean corpuscular hem... 48 | 50
female infertility 48 | 60
hydrometra 48 | 53
decreased blood urea nitrogen ... 46 | 51
decreased circulating total pr... 46 | 49
abnormal neural tube closure 45 | 46
abnormal skin morphology 45 | 50
decreased circulating alkaline... 45 | 46
increased blood urea nitrogen ... 45 | 48
decreased circulating alanine ... 44 | 47
increased hematocrit 42 | 46
increased neutrophil cell numb... 42 | 46
abnormal testis morphology 41 | 43
decreased hematocrit 41 | 46
increased hemoglobin content 41 | 45
increased circulating triglyce... 40 | 42
increased leukocyte cell numbe... 40 | 47
enlarged spleen 39 | 41
increased mean platelet volume 39 | 45
abnormal epididymis morphology 38 | 42
decreased red blood cell distr... 38 | 41
limb grasping 38 | 41
tremors 38 | 39
decreased circulating LDL chol... 37 | 38
decreased neutrophil cell numb... 37 | 42
increased circulating chloride... 37 | 41
abnormal bone mineralization 36 | 38
increased grip strength 36 | 41
abnormal cranium morphology 34 | 36
increased erythrocyte cell num... 34 | 39

Disease

Carcinoma 9,815 | 11,493
ovarian cancer 8,032 | 8,520
osteosarcoma 7,327 | 7,950
medulloblastoma, large-cell 5,758 | 6,241
psoriasis 5,724 | 6,694
glioblastoma 5,417 | 5,792
atypical teratoid / rhabdoid tumor 4,790 | 5,112
lung cancer 4,361 | 4,740
ependymoma 4,344 | 4,679
group 3 medulloblastoma 3,830 | 4,104
adult high grade glioma 3,469 | 3,801
Breast cancer 3,351 | 3,578
malignant mesothelioma 3,092 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,080 | 3,291
primitive neuroectodermal tumor 2,836 | 3,035
Astrocytoma, Pilocytic 2,812 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,768 | 2,989
invasive ductal carcinoma 2,741 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,733 | 2,955
oligodendroglioma 2,645 | 2,850
non-small cell lung cancer 2,629 | 2,890
lung carcinoma 2,500 | 2,843
lung adenocarcinoma 2,433 | 2,716
astrocytic glioma 2,406 | 2,597
Kidney cancer 2,298 | 2,613
Cancer 2,231 | 2,499
pancreatic cancer 2,217 | 2,398
subependymal giant cell astrocytoma 2,139 | 2,287
interstitial cystitis 2,030 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,863 | 1,962
tuberculosis 1,839 | 2,010
pituitary cancer 1,785 | 1,972
Pick disease 1,784 | 1,894
group 4 medulloblastoma 1,744 | 1,855
ductal carcinoma in situ 1,624 | 1,745
ulcerative colitis 1,620 | 1,819
cystic fibrosis 1,547 | 1,696
breast carcinoma 1,523 | 1,638
diabetes mellitus 1,363 | 1,728
colon cancer 1,339 | 1,478
adrenocortical carcinoma 1,334 | 1,428
Multiple myeloma 1,305 | 1,332
Autosomal recessive predisposition 1,279 | 1,442
juvenile dermatomyositis 1,140 | 1,187
acute quadriplegic myopathy 1,111 | 1,158
astrocytoma 1,100 | 1,146
Rheumatoid arthritis 1,098 | 1,191
primary pancreatic ductal adenocarcinoma 1,062 | 1,109
spina bifida 1,023 | 1,074
pediatric high grade glioma 1,014 | 1,064
Schizophrenia 989 | 1,160
nasopharyngeal carcinoma 956 | 1,058
Intellectual disability 953 | 1,016
dermatomyositis 937 | 966
cutaneous lupus erythematosus 905 | 1,057
active Crohn's disease 838 | 922
Atopic dermatitis 815 | 952
non primary Sjogren syndrome sicca 809 | 891
gastric carcinoma 760 | 807
acute myeloid leukemia 752 | 783
Waldenstrons macroglobulinemia 741 | 765
Epilepsy 729 | 792
active ulcerative colitis 688 | 764
Liver Cirrhosis, Experimental 686 | 769
esophageal adenocarcinoma 675 | 737
medulloblastoma 674 | 720
primary Sjogren syndrome 665 | 735
progressive supranuclear palsy 649 | 676
aldosterone-producing adenoma 628 | 665
Dull intelligence 606 | 645
Low intelligence 606 | 645
Mental Retardation 606 | 645
Mental deficiency 606 | 645
Poor school performance 606 | 645
Alzheimer's disease 580 | 658
Cognitive delay 580 | 608
Global developmental delay 580 | 608
Mental and motor retardation 580 | 608
Obesity 578 | 678
Bipolar Disorder 562 | 666
Melanoma 561 | 711
Duchenne muscular dystrophy 557 | 601
Seizures 549 | 596
Muscle hypotonia 548 | 571
Liver cancer 525 | 604
pancreatic carcinoma 523 | 562
hepatocellular carcinoma 522 | 547
fibroadenoma 514 | 559
Short stature 497 | 531
Endometriosis 494 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 489 | 510
Down syndrome 472 | 499
chronic rhinosinusitis 465 | 512
Prostatic Neoplasms 456 | 495
Multiple Sclerosis 445 | 540
sonic hedgehog group medulloblastoma 434 | 467
gastric cancer 433 | 459
posterior fossa group A ependymoma 430 | 468
Amyotrophic lateral sclerosis 423 | 451
Breast Neoplasms 414 | 445

Tissue

Endocrine System 15,922 | 18,159
Female tissues 15,692 | 17,400
Digestive Tract 15,682 | 17,369
Skin and soft tissues 15,633 | 17,230
Male tissues 15,553 | 17,142
Blood and immune system 15,445 | 16,909
Nervous System 15,399 | 16,725
Liver and Pancreas 15,352 | 16,750
Urinary Tract 15,309 | 16,678
Respiratory system 15,186 | 16,393
Cardiovascular System 14,317 | 15,192

Target Family

Non-IDG 9,455 | 12,091
Enzyme 3,663 | 4,145
Transcription Factor 1,245 | 1,400
Kinase 592 | 634
Transporter 397 | 473
Ion Channel 275 | 344
GPCR 258 | 408
Epigenetic 231 | 242
Nuclear Receptor 40 | 48
TF/Epigenetic 36 | 38
oGPCR 21 | 421

HCA RNA Cell Line

T-47d 16,213 | 16,213
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 140 ZNF140 Tdark Transcription Factor 0.08 0.97 39
DNA mismatch repair protein Msh6 MSH6 Tbio Epigenetic -2.72594 572.3 479
Nesprin-3 SYNE3 Tbio Non-IDG -0.90535 8.77 107
Calicin CCIN Tbio Non-IDG -1.20185 15.2 106
Phosphatidylinositol phosphatase PTPRQ PTPRQ Tbio Enzyme -1.10960 11.9 0
Synergin gamma SYNRG Tdark Non-IDG -1.69335 48.2 24
Melanoma-associated antigen B16 MAGEB16 Tdark Non-IDG -0.47591 3.29 54
Fragile X mental retardation syndrome-related protein 1 FXR1 Tbio Non-IDG -1.70770 50.9 220
Grainyhead-like protein 1 homolog GRHL1 Tbio Transcription Factor -1.58104 30.6 95