Development Level

Tbio 46 | 11,651
Tdark 11 | 6,593
Tchem 4 | 1,388

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 4 | 499
abnormal embryo size 3 | 220
decreased total body fat amoun... 3 | 207
abnormal behavioral response t... 2 | 66
decreased bone mineral content 2 | 151
decreased lean body mass 2 | 135
hyperactivity 2 | 148
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal limb morphology 1 | 13
abnormal lung morphology 1 | 26
abnormal outer ear morphology 1 | 3
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
absent pinna reflex 1 | 23
cataract 1 | 92
cyanosis 1 | 7
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased mean corpuscular hem... 1 | 50
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
long tibia 1 | 25
male infertility 1 | 123
microphthalmia 1 | 26
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97

Disease

Carcinoma 54 | 11,493
ovarian cancer 34 | 8,520
osteosarcoma 30 | 7,950
lung cancer 27 | 4,740
medulloblastoma, large-cell 27 | 6,241
atypical teratoid / rhabdoid tumor 26 | 5,112
glioblastoma 26 | 5,792
group 3 medulloblastoma 26 | 4,104
psoriasis 26 | 6,694
ependymoma 25 | 4,679
malignant mesothelioma 22 | 3,232
Breast cancer 21 | 3,578
adult high grade glioma 20 | 3,801
non-small cell lung cancer 18 | 2,890
Kidney cancer 17 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
invasive ductal carcinoma 16 | 2,951
Astrocytoma, Pilocytic 15 | 3,081
nasopharyngeal carcinoma 15 | 1,058
primitive neuroectodermal tumor 15 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
Liver cancer 13 | 604
lung adenocarcinoma 13 | 2,716
Endometriosis 11 | 540
adrenocortical carcinoma 11 | 1,428
colon cancer 11 | 1,478
ductal carcinoma in situ 11 | 1,745
oligodendroglioma 11 | 2,850
breast carcinoma 10 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
lung carcinoma 10 | 2,843
Atopic dermatitis 9 | 952
pancreatic cancer 9 | 2,398
Endometrial cancer 8 | 311
Small head 8 | 374
chronic rhinosinusitis 8 | 512
pituitary cancer 8 | 1,972
Intellectual disability 7 | 1,016
astrocytic glioma 7 | 2,597
subependymal giant cell astrocytoma 7 | 2,287
Autosomal recessive predisposition 6 | 1,442
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Microcephaly 6 | 166
interstitial cystitis 6 | 2,312
Dull intelligence 5 | 645
Epilepsy 5 | 792
Low intelligence 5 | 645
Melanoma 5 | 711
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Neurodegenerative disease 5 | 414
Neuropathy 5 | 261
Paraplegia 5 | 74
Pick disease 5 | 1,894
Poor school performance 5 | 645
Seizures 5 | 596
astrocytoma 5 | 1,146
group 4 medulloblastoma 5 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
ulcerative colitis 5 | 1,819
Anteverted nostril 4 | 191
Cancer 4 | 2,499
Fetal Growth Retardation 4 | 189
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Primary ciliary dyskinesia 4 | 76
Short stature 4 | 531
Skin cancer 4 | 469
cutaneous lupus erythematosus 4 | 1,057
diabetes mellitus 4 | 1,728
fibroadenoma 4 | 559
pediatric high grade glioma 4 | 1,064
spina bifida 4 | 1,074
Amyotrophic lateral sclerosis 3 | 451
Ciliary Dyskinesia, Primary, 1 3 | 27
Concave bridge of nose 3 | 195
Craniopharyngioma 3 | 16
DOID:2627 3 | 94
Decreased tendon reflex 3 | 122
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Downward slant of palpebral fissure 3 | 158
Hypoplastic feet 3 | 66
Malformations of Cortical Development 3 | 13
Muscle hypotonia 3 | 571
Polydactyly 3 | 107
Progressive muscular atrophy 3 | 7
Short nose 3 | 132
Sloping forehead 3 | 46
Slow progression 3 | 89
Small nose 3 | 132
juvenile dermatomyositis 3 | 1,187
non-small cell lung carcinoma 3 | 317
primary Sjogren syndrome 3 | 735
primary pancreatic ductal adenocarcinoma 3 | 1,109
progressive supranuclear palsy 3 | 676
tuberculosis 3 | 2,010
Micromelia 2 | 58

Tissue

Endocrine System 60 | 18,159
Respiratory system 59 | 16,393
Skin and soft tissues 59 | 17,230
Digestive Tract 58 | 17,369
Female tissues 58 | 17,400
Blood and immune system 57 | 16,909
Male tissues 57 | 17,142
Nervous System 57 | 16,725
Liver and Pancreas 55 | 16,750
Urinary Tract 55 | 16,678
Cardiovascular System 52 | 15,192

Target Family

Non-IDG 61 | 12,091

GO Function

microtubule motor activity 61 | 61
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dynein heavy chain 2, axonemal DNAH2 Tdark Non-IDG -0.65482 4.13 58
Dynein heavy chain 1, axonemal DNAH1 Tbio Non-IDG -1.30285 17.4 21
Dynein light chain roadblock-type 2 DYNLRB2 Tbio Non-IDG -0.65444 2.59 77
Dynein heavy chain 3, axonemal DNAH3 Tdark Non-IDG -1.15833 13.8 12
Dynein heavy chain 17, axonemal DNAH17 Tdark Non-IDG 0.27 0.43 9
Kinesin-like protein KIF15 KIF15 Tbio Non-IDG -1.54905 30.3 145
Cytoplasmic dynein 1 heavy chain 1 DYNC1H1 Tbio Non-IDG -1.80946 62.1 94
Dynein light chain roadblock-type 1 DYNLRB1 Tbio Non-IDG -2.23639 168.6 41
Centromere-associated protein E CENPE Tchem Non-IDG -2.14817 140.2 166
Kinesin heavy chain isoform 5C KIF5C Tbio Non-IDG -1.43450 25.5 119