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Target Filters...

Development Level

Tbio 101 | 10,625
Tchem 21 | 1,890
Tdark 10 | 7,003
Tclin 6 | 602

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

decreased lean body mass 5 | 195
decreased bone mineral content 4 | 157
decreased total body fat amoun... 4 | 186
decreased body length 3 | 108
decreased bone mineral density 3 | 126
preweaning lethality, complete... 3 | 633
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal sleep behavior 2 | 63
decreased body weight 2 | 174
decreased circulating insulin ... 2 | 75
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased rib number 2 | 59
male infertility 2 | 62
abnormal QRS complex 1 | 25
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 20
abnormal locomotor activation 1 | 26
abnormal nail morphology 1 | 7
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
cataract 1 | 26
corneal opacity 1 | 25
decreased caudal vertebrae num... 1 | 49
decreased circulating alkaline... 1 | 41
decreased circulating calcium ... 1 | 33
decreased circulating total pr... 1 | 41
decreased coping response 1 | 5
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased kidney weight 1 | 7
decreased lumbar vertebrae num... 1 | 62
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
decreased thoracic vertebrae n... 1 | 7
edema 1 | 11
embryonic lethality prior to t... 1 | 187
hydrops fetalis 1 | 22
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating iron lev... 1 | 25
increased exploration in new e... 1 | 56
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean platelet volume 1 | 19
increased or absent threshold ... 1 | 128
limb grasping 1 | 35
microphthalmia 1 | 15
oligodactyly 1 | 14
prenatal lethality 1 | 16
small testis 1 | 37
trunk curl 1 | 15

Disease

ovarian cancer 85 | 8,491
medulloblastoma, large-cell 75 | 6,234
glioblastoma 69 | 5,572
osteosarcoma 66 | 7,933
psoriasis 63 | 6,685
atypical teratoid / rhabdoid tumor 61 | 4,369
lung cancer 56 | 4,473
Cancer 46 | 2,346
lung carcinoma 44 | 2,844
primitive neuroectodermal tumor 43 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,988
malignant mesothelioma 41 | 3,163
oligodendroglioma 40 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,956
pilocytic astrocytoma 39 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,289
Breast cancer 37 | 3,098
pediatric high grade glioma 36 | 2,712
group 4 medulloblastoma 33 | 1,875
invasive ductal carcinoma 33 | 2,950
lung adenocarcinoma 33 | 2,714
non-small cell lung cancer 33 | 2,798
Carcinoma 32 | 2,147
cystic fibrosis 32 | 1,670
ependymoma 32 | 2,514
subependymal giant cell astrocytoma 31 | 2,287
astrocytoma 30 | 1,493
pancreatic cancer 30 | 2,300
pituitary cancer 28 | 1,972
sonic hedgehog group medulloblastoma 28 | 1,482
breast carcinoma 25 | 1,614
interstitial cystitis 24 | 2,299
ulcerative colitis 23 | 2,087
posterior fossa group A ependymoma 22 | 1,511
Pick disease 21 | 1,893
astrocytic glioma 21 | 2,241
adult high grade glioma 20 | 2,148
colon cancer 19 | 1,475
ductal carcinoma in situ 19 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,795
adrenocortical carcinoma 18 | 1,427
tuberculosis 18 | 1,563
atypical teratoid/rhabdoid tumor 17 | 1,095
group 3 medulloblastoma 17 | 2,254
cutaneous lupus erythematosus 16 | 1,056
posterior fossa group B ependymoma 16 | 1,530
medulloblastoma 15 | 1,524
Intellectual disability 14 | 573
esophageal adenocarcinoma 14 | 737
Rheumatoid Arthritis 12 | 1,170
primary Sjogren syndrome 12 | 788
primary pancreatic ductal adenocarcinoma 12 | 1,271
Multiple myeloma 11 | 1,327
acute quadriplegic myopathy 11 | 1,157
diabetes mellitus 11 | 1,663
Alzheimer's disease 10 | 644
Autistic Disorder 10 | 320
Cleft palate 10 | 125
Craniofacial Abnormalities 10 | 147
Prostatic Neoplasms 9 | 471
active ulcerative colitis 9 | 477
dermatomyositis 9 | 966
juvenile dermatomyositis 9 | 1,189
spina bifida 9 | 1,064
Atopic dermatitis 8 | 944
Cleft Lip 8 | 91
Duchenne muscular dystrophy 8 | 602
Kidney disease 8 | 397
Microphthalmia 8 | 79
Stomach Neoplasms 8 | 282
acute myeloid leukemia 8 | 785
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
nasopharyngeal carcinoma 8 | 1,056
progressive supranuclear palsy 8 | 674
Endometriosis 7 | 535
Mammary Neoplasms 7 | 410
Multiple Sclerosis 7 | 498
Obesity 7 | 616
Parkinson's disease 7 | 364
Waldenstrons macroglobulinemia 7 | 764
active Crohn's disease 7 | 918
Acquired metabolic disease 6 | 267
Holoprosencephaly 6 | 52
Lung Neoplasms 6 | 171
Osteoporosis 6 | 259
Schizophrenia 6 | 503
chronic lymphosyte leukemia 6 | 232
gastric cancer 6 | 436
gastric carcinoma 6 | 832
glioblastoma multiforme 6 | 347
interstitial lung disease 6 | 292
pancreatic carcinoma 6 | 567
tuberculosis and treatment for 6 months 6 | 686
urothelial carcinoma 6 | 318
Hydrolethalus syndrome 5 | 128
Polydactyly 5 | 93
chronic rhinosinusitis 5 | 512
fibroadenoma 5 | 557
inflammatory breast cancer 5 | 404
periodontitis 5 | 269

Tissue

Blood and immune system 137 | 17,994
Digestive Tract 137 | 18,472
Endocrine System 137 | 18,511
Female tissues 137 | 18,646
Liver and Pancreas 137 | 18,135
Male tissues 137 | 17,968
Nervous System 137 | 18,560
Urinary Tract 137 | 18,443
Cardiovascular System 136 | 17,957
Respiratory system 136 | 17,483
Skin and soft tissues 136 | 18,114

Target Family

Non-IDG 65 | 11,969
Transcription Factor 32 | 1,400
Enzyme 20 | 4,146
Kinase 7 | 634
Epigenetic 5 | 242
GPCR 4 | 408
Ion Channel 2 | 341
Nuclear Receptor 2 | 48
Transporter 1 | 473

WikiPathways Pathway

Ectoderm Differentiation 138 | 138
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 128 | 128
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ski-like protein SKIL Tbio Non-IDG -2.15950 140.8 225
Frizzled-8 FZD8 Tbio GPCR -1.60991 36.3 202
POU domain, class 2, transcription factor 2 POU2F2 Tchem Transcription Factor -1.45777 28.7 332
Transcriptional activator GLI3 GLI3 Tbio Transcription Factor -3.17428 1388.1 188
Bone morphogenetic protein 4 BMP4 Tchem Non-IDG -3.19530 1539.5 438