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Target Filters...

Development Level

Tbio 108 | 11,445
Tchem 18 | 1,598
Tclin 6 | 613
Tdark 6 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 10 | 979
preweaning lethality, incomple... 4 | 499
embryonic lethality prior to t... 3 | 278
abnormal behavior 2 | 298
decreased body weight 2 | 161
decreased circulating insulin ... 2 | 76
embryonic lethality prior to o... 2 | 239
hypoactivity 2 | 132
increased bone mineral density 2 | 72
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
male infertility 2 | 123
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal locomotor activation 1 | 16
abnormal nail morphology 1 | 8
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal stomach morphology 1 | 10
abnormal testis morphology 1 | 43
cataract 1 | 92
corneal opacity 1 | 32
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased coping response 1 | 8
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged heart 1 | 210
hydrometra 1 | 53
hydrops fetalis 1 | 1
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating insulin ... 1 | 3
increased circulating triglyce... 1 | 42
increased exploration in new e... 1 | 8
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
limb grasping 1 | 41
mammalian phenotype 1 | 17
microphthalmia 1 | 26
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74
small testis 1 | 58
trunk curl 1 | 16

Disease

Carcinoma 110 | 11,493
ovarian cancer 85 | 8,520
medulloblastoma, large-cell 75 | 6,241
atypical teratoid / rhabdoid tumor 73 | 5,112
glioblastoma 72 | 5,792
osteosarcoma 66 | 7,950
psoriasis 63 | 6,694
lung cancer 61 | 4,740
ependymoma 58 | 4,679
group 3 medulloblastoma 49 | 4,104
Cancer 48 | 2,499
Breast cancer 44 | 3,578
lung carcinoma 44 | 2,843
primitive neuroectodermal tumor 43 | 3,035
malignant mesothelioma 42 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,989
oligodendroglioma 40 | 2,850
Astrocytoma, Pilocytic 39 | 3,081
Kidney cancer 39 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,291
adult high grade glioma 36 | 3,801
non-small cell lung cancer 36 | 2,890
invasive ductal carcinoma 33 | 2,951
lung adenocarcinoma 33 | 2,716
pancreatic cancer 33 | 2,398
cystic fibrosis 32 | 1,696
subependymal giant cell astrocytoma 31 | 2,287
pituitary cancer 28 | 1,972
group 4 medulloblastoma 27 | 1,855
astrocytic glioma 26 | 2,597
breast carcinoma 26 | 1,638
astrocytoma 25 | 1,146
Intellectual disability 24 | 1,016
Short stature 24 | 531
interstitial cystitis 24 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
tuberculosis 22 | 2,010
Pick disease 21 | 1,894
pediatric high grade glioma 20 | 1,064
ulcerative colitis 20 | 1,819
colon cancer 19 | 1,478
ductal carcinoma in situ 19 | 1,745
adrenocortical carcinoma 18 | 1,428
Cryptorchidism 17 | 296
Dull intelligence 17 | 645
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Poor school performance 17 | 645
Schizophrenia 17 | 1,160
Autosomal recessive predisposition 16 | 1,442
Cognitive delay 16 | 608
Global developmental delay 16 | 608
Mental and motor retardation 16 | 608
cutaneous lupus erythematosus 16 | 1,057
Small head 15 | 374
Cleft Palate 14 | 271
Liver cancer 14 | 604
Melanoma 14 | 711
esophageal adenocarcinoma 14 | 737
Bipolar Disorder 13 | 666
Cleft Lip 13 | 141
Epilepsy 13 | 792
Hypoplastic mandible condyle 13 | 275
Mandibular hypoplasia 13 | 275
Micrognathism 13 | 275
Muscle hypotonia 13 | 571
Orbital separation excessive 13 | 244
diabetes mellitus 13 | 1,728
Strabismus 12 | 270
active ulcerative colitis 12 | 764
primary Sjogren syndrome 12 | 735
Liver Cirrhosis, Experimental 11 | 769
Multiple myeloma 11 | 1,332
Rheumatoid arthritis 11 | 1,191
Seizures 11 | 596
acute quadriplegic myopathy 11 | 1,158
Alzheimer's disease 10 | 658
Autistic Disorder 10 | 364
Blepharoptosis 10 | 231
Craniofacial Abnormalities 10 | 151
Prostatic Neoplasms 10 | 495
Ventricular Septal Defects 10 | 119
medulloblastoma 10 | 720
Abnormally small eyeball 9 | 97
Decreased size of eyeball 9 | 97
Failure to gain weight 9 | 365
Fetal Growth Retardation 9 | 189
Infant, Small for Gestational Age 9 | 176
Intrauterine retardation 9 | 176
Low set ears 9 | 181
Microphthalmos 9 | 100
Nystagmus 9 | 317
Pediatric failure to thrive 9 | 365
Stomach Neoplasms 9 | 300
dermatomyositis 9 | 966
juvenile dermatomyositis 9 | 1,187
posterior fossa group A ependymoma 9 | 468
spina bifida 9 | 1,074

Tissue

Endocrine System 137 | 18,159
Digestive Tract 136 | 17,369
Female tissues 136 | 17,400
Liver and Pancreas 135 | 16,750
Respiratory system 135 | 16,393
Urinary Tract 135 | 16,678
Male tissues 134 | 17,142
Nervous System 134 | 16,725
Skin and soft tissues 134 | 17,230
Blood and immune system 133 | 16,909
Cardiovascular System 126 | 15,192

Target Family

Non-IDG 65 | 12,091
Transcription Factor 32 | 1,400
Enzyme 20 | 4,145
Kinase 7 | 634
Epigenetic 5 | 242
GPCR 4 | 408
Ion Channel 2 | 344
Nuclear Receptor 2 | 48
Transporter 1 | 473

WikiPathways Pathway

Ectoderm Differentiation 138 | 138
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.80290 601.6 434