Development Level

Tbio 85 | 11,445
Tchem 34 | 1,598
Tclin 29 | 613
Tdark 4 | 6,588

Collection

Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

increased startle reflex 10 | 112
preweaning lethality, incomple... 8 | 499
abnormal behavior 7 | 298
preweaning lethality, complete... 7 | 979
hyperactivity 6 | 148
abnormal embryo size 5 | 220
decreased vertical activity 5 | 208
edema 5 | 59
embryonic lethality prior to t... 5 | 278
abnormal bone structure 4 | 187
decreased prepulse inhibition 4 | 82
increased heart weight 4 | 62
abnormal retina morphology 3 | 71
cardiovascular system phenotyp... 3 | 36
decreased fasted circulating g... 3 | 65
decreased total body fat amoun... 3 | 207
enlarged heart 3 | 210
increased circulating alkaline... 3 | 122
increased circulating sodium l... 3 | 71
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal spleen morphology 2 | 55
abnormal vibrissa morphology 2 | 25
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating amylase ... 2 | 28
decreased eosinophil cell numb... 2 | 24
decreased heart rate variabili... 2 | 13
embryonic growth retardation 2 | 106
enlarged epididymis 2 | 31
enlarged spleen 2 | 41
impaired glucose tolerance 2 | 75
increased circulating alanine ... 2 | 13
increased circulating triglyce... 2 | 42
short tibia 2 | 97
thrombocytopenia 2 | 56
abnormal facial morphology 1 | 17
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal locomotor behavior 1 | 24
abnormal pericardium morpholog... 1 | 26
abnormal placenta vasculature 1 | 2
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
absent vibrissae 1 | 12
cyanosis 1 | 7
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hydrometra 1 | 53
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
limb grasping 1 | 41
male infertility 1 | 123
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
respiratory system phenotype 1 | 2
small epididymis 1 | 3
small kidney 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
vertebral fusion 1 | 23

Disease

Carcinoma 98 | 11,493
medulloblastoma, large-cell 97 | 6,241
glioblastoma 83 | 5,792
osteosarcoma 83 | 7,950
ovarian cancer 83 | 8,520
ependymoma 77 | 4,679
atypical teratoid / rhabdoid tumor 75 | 5,112
psoriasis 75 | 6,694
adult high grade glioma 72 | 3,801
Astrocytoma, Pilocytic 62 | 3,081
primitive neuroectodermal tumor 62 | 3,035
group 3 medulloblastoma 59 | 4,104
oligodendroglioma 56 | 2,850
astrocytic glioma 55 | 2,597
lung adenocarcinoma 49 | 2,716
lung cancer 49 | 4,740
Breast cancer 48 | 3,578
lung carcinoma 46 | 2,843
subependymal giant cell astrocytoma 43 | 2,287
non-small cell lung cancer 41 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,989
invasive ductal carcinoma 36 | 2,951
pancreatic cancer 36 | 2,398
Kidney cancer 35 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,291
malignant mesothelioma 34 | 3,232
Schizophrenia 33 | 1,160
pituitary cancer 33 | 1,972
interstitial cystitis 32 | 2,312
Pick disease 31 | 1,894
ulcerative colitis 30 | 1,819
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
colon cancer 26 | 1,478
group 4 medulloblastoma 26 | 1,855
Hypertension 25 | 396
Bipolar Disorder 24 | 666
cystic fibrosis 24 | 1,696
Cancer 22 | 2,499
Epilepsy 22 | 792
ductal carcinoma in situ 22 | 1,745
diabetes mellitus 21 | 1,728
tuberculosis 21 | 2,010
Hypertensive disease 20 | 292
breast carcinoma 20 | 1,638
Parkinson's disease 18 | 392
acute quadriplegic myopathy 18 | 1,158
Depressive disorder 17 | 409
Liver Cirrhosis, Experimental 16 | 769
Liver cancer 16 | 604
Obesity 16 | 678
astrocytoma 16 | 1,146
Heart disease 15 | 306
Rheumatoid arthritis 15 | 1,191
Autosomal recessive predisposition 14 | 1,442
Mood Disorders 14 | 184
Seizures 14 | 596
juvenile dermatomyositis 14 | 1,187
primary pancreatic ductal adenocarcinoma 14 | 1,109
Atrial Fibrillation 13 | 124
Intellectual disability 13 | 1,016
Major Depressive Disorder 13 | 301
Adenoma 12 | 167
Unipolar Depression 12 | 250
pediatric high grade glioma 12 | 1,064
Duchenne muscular dystrophy 11 | 601
Mental Depression 11 | 333
adrenocortical carcinoma 11 | 1,428
dermatomyositis 11 | 966
non primary Sjogren syndrome sicca 11 | 891
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
spina bifida 11 | 1,074
Carney complex 10 | 25
Malignant hyperthermia 10 | 26
Melanoma 10 | 711
Skin cancer 10 | 469
active Crohn's disease 10 | 922
aldosterone-producing adenoma 10 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 510
Asthma 9 | 385
Atopic dermatitis 9 | 952
Crohn's disease 9 | 321
Diabetes Mellitus, Experimental 9 | 108
Hypertensive disorder 9 | 56
Multiple myeloma 9 | 1,332
Substance Withdrawal Syndrome 9 | 55
Waldenstrons macroglobulinemia 9 | 765
active ulcerative colitis 9 | 764
Autistic Disorder 8 | 364
Chronic heart failure 8 | 46
Congestive heart failure 8 | 113
Endometrial cancer 8 | 311
Erythrokeratodermia variabilis 8 | 10
Essential Hypertension 8 | 94
Oculodentodigital dysplasia 8 | 14
Primary pigmented nodular adrenocortical disease 8 | 13
Ventricular arrhythmia 8 | 27
cutaneous lupus erythematosus 8 | 1,057
pancreatic carcinoma 8 | 562
primary Sjogren syndrome 8 | 735
Prostatic Neoplasms 7 | 495

Tissue

Endocrine System 149 | 18,159
Digestive Tract 147 | 17,369
Female tissues 147 | 17,400
Skin and soft tissues 147 | 17,230
Nervous System 145 | 16,725
Male tissues 144 | 17,142
Urinary Tract 144 | 16,678
Blood and immune system 143 | 16,909
Liver and Pancreas 142 | 16,750
Respiratory system 136 | 16,393
Cardiovascular System 130 | 15,192

Target Family

Non-IDG 74 | 12,091
Kinase 20 | 634
Enzyme 19 | 4,145
Ion Channel 17 | 344
GPCR 11 | 408
Transporter 11 | 473

WikiPathways Pathway

Calcium Regulation in the Card... 152 | 152
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alpha-1A adrenergic receptor ADRA1A Tclin GPCR -2.18682 155.5 236
Beta-3 adrenergic receptor ADRB3 Tclin GPCR -2.73090 568.4 254
Gap junction alpha-5 protein GJA5 Tbio Non-IDG -2.59423 377.5 194
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 PLCB3 Tbio Enzyme -1.88444 66.2 265
Regulator of G-protein signaling 10 RGS10 Tbio Non-IDG -1.42892 32.0 146