Development Level

Tbio 138 | 10,625
Tdark 40 | 7,003
Tchem 7 | 1,890

Collection

Kinase: IDG Consortium (Targets) 3 | 125

IMPC Phenotype

preweaning lethality, complete... 7 | 633
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 3 | 187
enlarged heart 2 | 111
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal coat-hair pigmentatio... 1 | 54
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal rib morphology 1 | 28
abnormal seminal vesicle morph... 1 | 47
decreased NK cell number 1 | 16
decreased body weight 1 | 174
decreased circulating chloride... 1 | 32
decreased circulating sodium l... 1 | 18
increased KLRG1-positive NK ce... 1 | 9
increased NK cell number 1 | 19
increased circulating chloride... 1 | 43
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 68
increased granulocyte number 1 | 8
increased mean platelet volume 1 | 19
prenatal lethality prior to he... 1 | 64

Disease

ovarian cancer 84 | 8,491
lung cancer 65 | 4,473
osteosarcoma 55 | 7,933
medulloblastoma, large-cell 46 | 6,234
psoriasis 40 | 6,685
diabetes mellitus 36 | 1,663
Multiple myeloma 34 | 1,327
group 3 medulloblastoma 32 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,289
colon cancer 27 | 1,475
glioblastoma 27 | 5,572
Diamond-Blackfan anemia 25 | 30
Waldenstrons macroglobulinemia 25 | 764
malignant mesothelioma 23 | 3,163
acute quadriplegic myopathy 20 | 1,157
atypical teratoid / rhabdoid tumor 20 | 4,369
sonic hedgehog group medulloblastoma 20 | 1,482
invasive ductal carcinoma 16 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
pediatric high grade glioma 15 | 2,712
non-small cell lung cancer 14 | 2,798
oligodendroglioma 14 | 2,849
Anemia, Diamond-Blackfan 13 | 15
Disease Progression 13 | 125
Stomach Neoplasms 13 | 282
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,988
primitive neuroectodermal tumor 12 | 3,031
Breast cancer 11 | 3,098
ependymoma 11 | 2,514
non primary Sjogren syndrome sicca 10 | 840
Anemia 9 | 252
acute myeloid leukemia 9 | 785
astrocytoma 9 | 1,493
cystic fibrosis 9 | 1,670
subependymal giant cell astrocytoma 9 | 2,287
Bowen-Conradi syndrome 8 | 16
adult high grade glioma 8 | 2,148
atypical teratoid/rhabdoid tumor 8 | 1,095
lung adenocarcinoma 8 | 2,714
pilocytic astrocytoma 8 | 3,086
Carcinoma 7 | 2,147
Mammary Neoplasms 7 | 410
astrocytic glioma 7 | 2,241
mucosa-associated lymphoid tissue lymphoma 7 | 480
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
Cancer 6 | 2,346
Rheumatoid Arthritis 6 | 1,170
cutaneous lupus erythematosus 6 | 1,056
group 4 medulloblastoma 6 | 1,875
inflammatory breast cancer 6 | 404
juvenile dermatomyositis 6 | 1,189
pancreatic cancer 6 | 2,300
Systemic scleroderma 5 | 66
dermatomyositis 5 | 966
glioblastoma multiforme 5 | 347
hepatocellular carcinoma 5 | 550
medulloblastoma 5 | 1,524
posterior fossa group B ependymoma 5 | 1,530
tuberculosis and treatment for 6 months 5 | 686
Dyskeratosis congenita 4 | 24
Parkinson Disease 4 | 105
Polycystic Ovary Syndrome 4 | 334
Treacher Collins syndrome 4 | 29
X-linked cerebral adrenoleukodystrophy 4 | 115
breast carcinoma 4 | 1,614
spina bifida 4 | 1,064
Animal Mammary Neoplasms 3 | 135
Duchenne muscular dystrophy 3 | 602
Irregular astigmatism 3 | 11
Mammary Neoplasms, Experimental 3 | 149
Neurodegenerative disease 3 | 383
Osteoporosis 3 | 259
Pick disease 3 | 1,893
Prostatic Neoplasms 3 | 471
Pure red-cell aplasia 3 | 4
Renal Cell Carcinoma 3 | 199
Shwachman-Diamond syndrome 3 | 16
Weight Gain 3 | 87
active Crohn's disease 3 | 918
adrenocortical carcinoma 3 | 1,427
ductal carcinoma in situ 3 | 1,745
gastric carcinoma 3 | 832
pancreatic carcinoma 3 | 567
pituitary cancer 3 | 1,972
posterior fossa group A ependymoma 3 | 1,511
ulcerative colitis 3 | 2,087
Amyotrophic Lateral Sclerosis 2 | 432
Anoxia 2 | 33
Cerebellar Ataxia 2 | 72
Glaucoma 2 | 135
Kennedy's disease 2 | 13
Melanoma 2 | 261
Peripheral Neuropathy 2 | 303
Pontocerebellar hypoplasia 2 | 29
Sensorineural hearing loss 2 | 107
Turner syndrome 2 | 31
aldosterone-producing adenoma 2 | 664
hereditary spastic paraplegia 2 | 313
interleukin-7 receptor alpha deficiency 2 | 16
systemic lupus erythematosus 2 | 172

Tissue

Blood and immune system 185 | 17,994
Digestive Tract 185 | 18,472
Female tissues 185 | 18,646
Liver and Pancreas 185 | 18,135
Male tissues 185 | 17,968
Nervous System 185 | 18,560
Cardiovascular System 184 | 17,957
Endocrine System 183 | 18,511
Urinary Tract 183 | 18,443
Respiratory system 182 | 17,483
Skin and soft tissues 180 | 18,114

Target Family

Non-IDG 149 | 11,969
Enzyme 31 | 4,146
Kinase 5 | 634

Reactome Pathway

rRNA processing in the nucleus... 185 | 185
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Small subunit processome component 20 homolog UTP20 Tbio Non-IDG -1.36937 23.3 35
HEAT repeat-containing protein 1 HEATR1 Tdark Non-IDG -0.66118 5.48 26
Ribosomal RNA small subunit methyltransferase NEP1 EMG1 Tdark Enzyme 0.00000 97
Ubiquitin-like protein FUBI FAU Tbio Non-IDG -2.11439 236.8 235
Casein kinase I isoform delta CSNK1D Tchem Kinase -2.00706 88.3 252
60S ribosomal protein L37 RPL37 Tbio Non-IDG -1.41508 24.7 97
Exosome complex component RRP45 EXOSC9 Tbio Enzyme -1.15491 13.5 87
40S ribosomal protein S29 RPS29 Tbio Non-IDG -1.07143 12.6 37
rRNA 2'-O-methyltransferase fibrillarin FBL Tbio Enzyme -3.21781 1580.2 240
40S ribosomal protein S3 RPS3 Tbio Non-IDG -2.17363 152.6 207