Development Level

Tbio 42 | 11,651
Tdark 11 | 6,593
Tchem 2 | 1,388

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 2 | 278
abnormal behavior 1 | 298
abnormal posture 1 | 2
abnormal retina morphology 1 | 71
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased circulating sodium l... 1 | 22
increased anti-nuclear antigen... 1 | 19
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29

Disease

ovarian cancer 27 | 8,520
lung cancer 21 | 4,740
Carcinoma 20 | 11,493
psoriasis 17 | 6,694
osteosarcoma 15 | 7,950
Breast cancer 13 | 3,578
Multiple myeloma 11 | 1,332
lung adenocarcinoma 11 | 2,716
glioblastoma 10 | 5,792
invasive ductal carcinoma 10 | 2,951
Cancer 9 | 2,499
Cockayne syndrome 9 | 60
Photosensitive trichothiodystrophy 9 | 30
breast carcinoma 9 | 1,638
ductal carcinoma in situ 9 | 1,745
non-small cell lung cancer 9 | 2,890
atypical teratoid / rhabdoid tumor 8 | 5,112
group 3 medulloblastoma 8 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
malignant mesothelioma 7 | 3,232
medulloblastoma, large-cell 7 | 6,241
pancreatic cancer 7 | 2,398
Cleft Palate 6 | 271
Xeroderma pigmentosum 6 | 43
Xeroderma pigmentosum group B 6 | 20
colon cancer 6 | 1,478
ependymoma 6 | 4,679
group 4 medulloblastoma 6 | 1,855
Pick disease 5 | 1,894
Xeroderma pigmentosum group D 5 | 33
cystic fibrosis 5 | 1,696
nasopharyngeal carcinoma 5 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Hypoplastic mandible condyle 4 | 275
Intellectual disability 4 | 1,016
Mandibular hypoplasia 4 | 275
Micrognathism 4 | 275
Strabismus 4 | 270
Treacher Collins syndrome 4 | 27
Xeroderma pigmentosum group G 4 | 16
acute myeloid leukemia 4 | 783
cutaneous lupus erythematosus 4 | 1,057
diabetes mellitus 4 | 1,728
gastric cancer 4 | 459
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
non-small cell lung carcinoma 4 | 317
pancreatic carcinoma 4 | 562
pediatric high grade glioma 4 | 1,064
pituitary cancer 4 | 1,972
primitive neuroectodermal tumor 4 | 3,035
spina bifida 4 | 1,074
Autosomal recessive predisposition 3 | 1,442
Breast Neoplasms 3 | 445
Broad flat nasal bridge 3 | 236
Cerebellar Ataxia 3 | 304
Congenital small ears 3 | 48
Connective tissue disease 3 | 62
Decreased projection of maxilla 3 | 66
Deficiency of upper jaw bones 3 | 66
Downward slant of palpebral fissure 3 | 158
Dull intelligence 3 | 645
Hereditary spherocytosis type 5 3 | 12
Hypoplasia of the maxilla 3 | 66
Hypotrophic maxilla 3 | 66
Low Vision 3 | 174
Low intelligence 3 | 645
Lupus erythematosus 3 | 57
Mammary Neoplasms 3 | 425
Maxillary retrognathia 3 | 66
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Nasal bridge wide 3 | 236
Poor school performance 3 | 645
Retrusion of upper jaw bones 3 | 66
Schizophrenia 3 | 1,160
Small head 3 | 374
Treacher Collins syndrome 1 3 | 4
Trichothiodystrophy 1, photosensitive 3 | 4
Trichothiodystrophy Syndromes 3 | 6
Uranostaphyloschisis 3 | 167
Visual Impairment 3 | 174
Waldenstrons macroglobulinemia 3 | 765
dermatomyositis 3 | 966
hepatocellular carcinoma 3 | 547
sonic hedgehog group medulloblastoma 3 | 467
Abnormal skeletal development 2 | 60
Arsenic Poisoning 2 | 62
Conductive hearing loss 2 | 123
Congenital deafness 2 | 185
Deafness 2 | 198
Dermatologic disorders 2 | 93
Fever 2 | 138
Hearing Loss, Partial 2 | 185
Keratitis 2 | 62
Narrow internal auditory canal 2 | 8
Osteochondrodysplasias 2 | 72
Retrognathia 2 | 54
Sensorineural Hearing Loss (disorder) 2 | 284
hearing impairment 2 | 199

Tissue

Endocrine System 54 | 18,159
Blood and immune system 53 | 16,909
Digestive Tract 53 | 17,369
Female tissues 53 | 17,400
Skin and soft tissues 53 | 17,230
Cardiovascular System 52 | 15,192
Liver and Pancreas 52 | 16,750
Male tissues 52 | 17,142
Nervous System 52 | 16,725
Respiratory system 52 | 16,393
Urinary Tract 52 | 16,678

Target Family

Non-IDG 33 | 12,091
Enzyme 20 | 4,145
Kinase 1 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

RNA Polymerase I Chain Elongat... 55 | 55
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Histone H2A.J H2AFJ Tdark Non-IDG -0.00172 0.83 99
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.13403 13.5 180
DNA-directed RNA polymerases I, II, and III subunit RPABC2 POLR2F Tbio Enzyme -1.13403 13.9 68
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.27041 18.5 133
Histone H2B type 1-K HIST1H2BK Tbio Non-IDG -0.50219 4.04 29
DNA-directed RNA polymerase I subunit RPA1 POLR1A Tchem Enzyme -1.18783 12.6 87
Histone H2B type 3-B HIST3H2BB Tbio Non-IDG -0.72238 5.02 53
Histone H2A type 1-D HIST1H2AD Tdark Non-IDG 0.17 0.32 11