Development Level

Tbio 27 | 11,445
Tclin 11 | 613
Tchem 8 | 1,598

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal vertebrae morphology 1 | 18
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body length 1 | 101
decreased eosinophil cell numb... 1 | 24
decreased lean body mass 1 | 135
decreased respiratory quotient 1 | 16
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glycerol... 1 | 9
increased hemoglobin content 1 | 45
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112

Disease

Carcinoma 34 | 11,493
ovarian cancer 28 | 8,520
Cancer 27 | 2,499
osteosarcoma 22 | 7,950
glioblastoma 21 | 5,792
lung cancer 21 | 4,740
psoriasis 19 | 6,694
Multiple myeloma 18 | 1,332
Breast cancer 17 | 3,578
medulloblastoma, large-cell 17 | 6,241
atypical teratoid / rhabdoid tumor 15 | 5,112
ependymoma 14 | 4,679
group 3 medulloblastoma 14 | 4,104
Peripheral T-cell lymphoma 13 | 25
Primary cutaneous T-cell lymphoma 13 | 29
adult high grade glioma 13 | 3,801
astrocytoma 13 | 1,146
oligodendroglioma 13 | 2,850
Astrocytoma, Pilocytic 11 | 3,081
astrocytic glioma 11 | 2,597
malignant mesothelioma 11 | 3,232
Breast Neoplasms 10 | 445
Mammary Neoplasms 10 | 425
interstitial cystitis 10 | 2,312
tuberculosis 10 | 2,010
Kidney cancer 9 | 2,613
invasive ductal carcinoma 9 | 2,951
lung carcinoma 9 | 2,843
primitive neuroectodermal tumor 9 | 3,035
subependymal giant cell astrocytoma 9 | 2,287
acute myeloid leukemia 8 | 783
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
Mental Depression 7 | 333
Schizophrenia 7 | 1,160
acute quadriplegic myopathy 7 | 1,158
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
pituitary cancer 7 | 1,972
Carcinoma, Squamous Cell 6 | 110
Rheumatoid arthritis 6 | 1,191
breast carcinoma 6 | 1,638
gastric carcinoma 6 | 807
Adenoid Cystic Carcinoma 5 | 99
Bipolar Disorder 5 | 666
Bladder Neoplasm 5 | 112
Carcinoma, Adenoid Cystic 5 | 99
Esophageal Squamous Cell Carcinoma 5 | 77
Immune system cancer 5 | 140
Intellectual disability 5 | 1,016
Lymphoid leukemia 5 | 160
Mood Disorders 5 | 184
Pick disease 5 | 1,894
Squamous cell carcinoma 5 | 129
Squamous cell carcinoma of esophagus 5 | 77
Urinary Bladder Neoplasms 5 | 114
cystic fibrosis 5 | 1,696
ductal carcinoma in situ 5 | 1,745
group 4 medulloblastoma 5 | 1,855
lung adenocarcinoma 5 | 2,716
non-small cell lung cancer 5 | 2,890
pancreatic cancer 5 | 2,398
ulcerative colitis 5 | 1,819
Alzheimer's disease 4 | 658
Carcinoma, Pancreatic Ductal 4 | 20
Cataract 4 | 297
Depressive disorder 4 | 409
Endometriosis 4 | 540
Epilepsy 4 | 792
Failure to gain weight 4 | 365
Frontal bossing 4 | 157
Glaucoma 4 | 239
Lens Opacities 4 | 231
Neuronal ceroid lipofuscinosis 2 4 | 17
Pediatric failure to thrive 4 | 365
Prostatic Neoplasms 4 | 495
Seizures 4 | 596
Short stature 4 | 531
Small head 4 | 374
Strabismus 4 | 270
adrenocortical carcinoma 4 | 1,428
juvenile dermatomyositis 4 | 1,187
medulloblastoma 4 | 720
pediatric high grade glioma 4 | 1,064
primary pancreatic ductal adenocarcinoma 4 | 1,109
Bilateral fifth finger clinodactyly 3 | 110
Cerebrovascular disease 3 | 238
Colonic Neoplasms 3 | 142
Curvature of little finger 3 | 110
Down syndrome 3 | 499
Endometrial cancer 3 | 311
Heart disease 3 | 306
Lung Neoplasms 3 | 232
Major Depressive Disorder 3 | 301
Unipolar Depression 3 | 250
Vascular disease 3 | 319
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
colon cancer 3 | 1,478
cutaneous lupus erythematosus 3 | 1,057
progressive supranuclear palsy 3 | 676

Tissue

Blood and immune system 46 | 16,909
Cardiovascular System 46 | 15,192
Digestive Tract 46 | 17,369
Endocrine System 46 | 18,159
Female tissues 46 | 17,400
Liver and Pancreas 46 | 16,750
Male tissues 46 | 17,142
Nervous System 46 | 16,725
Respiratory system 46 | 16,393
Skin and soft tissues 46 | 17,230
Urinary Tract 46 | 16,678

Target Family

Non-IDG 18 | 12,091
Epigenetic 15 | 242
Transcription Factor 10 | 1,400
Enzyme 2 | 4,145
Kinase 1 | 634

Reactome Pathway

NOTCH1 Intracellular Domain Re... 46 | 46
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Recombining binding protein suppressor of hairless RBPJ Tbio Transcription Factor -2.67790 444.5 266
Nuclear receptor corepressor 1 NCOR1 Tchem Transcription Factor -2.51676 305.9 290
Histone acetyltransferase KAT2B KAT2B Tchem Epigenetic -2.62847 372.0 331
CREB-binding protein CREBBP Tchem Epigenetic -2.81657 471.6 449
Neurogenic locus notch homolog protein 1 NOTCH1 Tchem Non-IDG -4.08071 11843.2 916
Histone deacetylase 2 HDAC2 Tclin Epigenetic -2.79651 587.9 712
Histone deacetylase 11 HDAC11 Tclin Epigenetic -2.27888 181.5 353