Development Level

Tbio 74 | 10,625
Tdark 20 | 7,003
Tchem 17 | 1,890

IMPC Phenotype

preweaning lethality, complete... 17 | 633
embryonic lethality prior to t... 5 | 187
abnormal embryo size 4 | 112
decreased circulating alanine ... 3 | 53
decreased circulating glucose ... 3 | 121
embryonic lethality prior to o... 3 | 148
abnormal behavior 2 | 226
abnormal lens morphology 2 | 73
decreased bone mineral content 2 | 157
decreased circulating aspartat... 2 | 27
decreased circulating choleste... 2 | 85
decreased circulating free fat... 2 | 39
decreased grip strength 2 | 123
decreased startle reflex 2 | 48
hyperactivity 2 | 108
increased or absent threshold ... 2 | 128
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal facial morphology 1 | 9
abnormal head shape 1 | 4
abnormal hindbrain development 1 | 24
abnormal limb morphology 1 | 7
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal outer ear morphology 1 | 1
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
abnormal testis morphology 1 | 30
absent pinna reflex 1 | 21
cataract 1 | 26
cyanosis 1 | 6
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased circulating total pr... 1 | 41
decreased effector memory CD4-... 1 | 6
decreased hematocrit 1 | 25
decreased lactate dehydrogenas... 1 | 14
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased red blood cell distr... 1 | 11
decreased rib number 1 | 59
decreased total body fat amoun... 1 | 186
embryonic growth retardation 1 | 28
hemorrhage 1 | 12
immune system phenotype 1 | 17
impaired glucose tolerance 1 | 52
impaired pupillary reflex 1 | 14
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased sacral vertebrae num... 1 | 62
limb grasping 1 | 35
male infertility 1 | 62
prenatal lethality prior to he... 1 | 64
small testis 1 | 37
thrombocytosis 1 | 23

Disease

ovarian cancer 69 | 8,491
glioblastoma 57 | 5,572
osteosarcoma 57 | 7,933
medulloblastoma, large-cell 50 | 6,234
atypical teratoid / rhabdoid tumor 43 | 4,369
lung cancer 38 | 4,473
pediatric high grade glioma 35 | 2,712
psoriasis 35 | 6,685
Breast cancer 32 | 3,098
malignant mesothelioma 28 | 3,163
primitive neuroectodermal tumor 28 | 3,031
non-small cell lung cancer 27 | 2,798
pilocytic astrocytoma 26 | 3,086
lung adenocarcinoma 25 | 2,714
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,988
invasive ductal carcinoma 24 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
oligodendroglioma 21 | 2,849
group 3 medulloblastoma 20 | 2,254
Carcinoma 19 | 2,147
adrenocortical carcinoma 19 | 1,427
breast carcinoma 19 | 1,614
Multiple myeloma 18 | 1,327
posterior fossa group B ependymoma 18 | 1,530
astrocytoma 17 | 1,493
colon cancer 17 | 1,475
ependymoma 17 | 2,514
Pick disease 16 | 1,893
diabetes mellitus 15 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
ductal carcinoma in situ 14 | 1,745
group 4 medulloblastoma 14 | 1,875
lung carcinoma 14 | 2,844
pancreatic cancer 14 | 2,300
pituitary cancer 14 | 1,972
Atopic dermatitis 13 | 944
adult high grade glioma 13 | 2,148
posterior fossa group A ependymoma 13 | 1,511
acute quadriplegic myopathy 12 | 1,157
sonic hedgehog group medulloblastoma 12 | 1,482
astrocytic glioma 11 | 2,241
dermatomyositis 11 | 966
medulloblastoma 11 | 1,524
subependymal giant cell astrocytoma 11 | 2,287
IGA Glomerulonephritis 10 | 454
juvenile dermatomyositis 10 | 1,189
nasopharyngeal carcinoma 10 | 1,056
Endometriosis 9 | 535
Neurodegenerative disease 9 | 383
tuberculosis and treatment for 6 months 9 | 686
Microcephaly 8 | 149
Paraplegia 8 | 71
active Crohn's disease 8 | 918
interstitial cystitis 8 | 2,299
non primary Sjogren syndrome sicca 8 | 840
spina bifida 7 | 1,064
Amyotrophic Lateral Sclerosis 6 | 432
Cancer 6 | 2,346
Neuropathy 6 | 210
Rheumatoid Arthritis 6 | 1,170
atypical teratoid/rhabdoid tumor 6 | 1,095
cutaneous lupus erythematosus 6 | 1,056
inflammatory breast cancer 6 | 404
tuberculosis 6 | 1,563
Intellectual disability 5 | 573
acute myeloid leukemia 5 | 785
cystic fibrosis 5 | 1,670
esophageal adenocarcinoma 5 | 737
hereditary spastic paraplegia 5 | 313
pancreatic carcinoma 5 | 567
primary Sjogren syndrome 5 | 788
primary pancreatic ductal adenocarcinoma 5 | 1,271
ulcerative colitis 5 | 2,087
Alzheimer's disease 4 | 644
Duchenne muscular dystrophy 4 | 602
Parkinson's disease 4 | 364
Waldenstrons macroglobulinemia 4 | 764
Warburg micro syndrome 4 | 19
active ulcerative colitis 4 | 477
hepatocellular carcinoma 4 | 550
Charcot-Marie-Tooth disease 3 | 74
Gaucher disease type 1 3 | 171
Legionnaires' disease 3 | 20
Lissencephaly 3 | 61
Malformations of Cortical Development 3 | 11
Menkes disease 3 | 20
Polycystic kidney disease 3 | 54
Schizophrenia 3 | 503
Warburg Sjo Fledelius syndrome 3 | 4
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
cystic fibrosis and chronic rhinosinusitis 3 | 213
fibroadenoma 3 | 557
gastric cancer 3 | 436
gastric carcinoma 3 | 832
progressive supranuclear palsy 3 | 674
Attention deficit hyperactivity disorder 2 | 156
Down syndrome 2 | 548
Myocardial Ischemia 2 | 169
Prostatic Neoplasms 2 | 471

Tissue

Blood and immune system 110 | 17,994
Cardiovascular System 110 | 17,957
Digestive Tract 110 | 18,472
Endocrine System 110 | 18,511
Female tissues 110 | 18,646
Liver and Pancreas 110 | 18,135
Male tissues 110 | 17,968
Nervous System 110 | 18,560
Urinary Tract 110 | 18,443
Respiratory system 109 | 17,483
Skin and soft tissues 109 | 18,114

Target Family

Non-IDG 87 | 11,969
Enzyme 24 | 4,146

Reactome Pathway

Golgi-to-ER retrograde transpo... 111 | 111
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kinesin-like protein KIF21B KIF21B Tbio Non-IDG -1.01878 9.49 31
RAD50-interacting protein 1 RINT1 Tbio Non-IDG -1.26211 17.4 52
Kinesin-like protein KIF18A KIF18A Tbio Non-IDG -1.44834 29.6 81
Coatomer subunit delta ARCN1 Tbio Non-IDG -0.85154 6.13 105
Transmembrane emp24 domain-containing protein 10 TMED10 Tbio Non-IDG -1.45219 31.4 277
ER lumen protein-retaining receptor 1 KDELR1 Tbio Non-IDG -2.26118 170.8 122
Surfeit locus protein 4 SURF4 Tbio Non-IDG -1.19013 16.6 84
ADP-ribosylation factor 1 ARF1 Tchem Enzyme -2.51304 358.0 192
Kinesin-like protein KIF19 KIF19 Tdark Non-IDG -0.35218 2.17 52
Coatomer subunit epsilon COPE Tbio Non-IDG -1.60477 40.7 89